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The transcription factor ZNF224 plays a key proapoptotic role in chronic myelogenous leukemia (CML), by modulating Wilms Tumor protein 1 (WT1) dependent apoptotic genes transcription. Recently, we demonstrated that Bcr-Abl signaling represses ZNF224 expression in Bcr-Abl positive CML cell lines and in CML patients. Interestingly, Imatinib and second-generation tyrosine kinase inhibitors specifical
We propose data-driven surrogate models to solve systems of time-dependent differential equations coupled with noise. Using a feedforward neural network, we separately learn the noise and solution, tackling approximations across regimes with bifurcations and rare events. Focusing on irregular data generated by a stochastic noise model on a one-dimensional spatial lattice coupled to a differential
Objective: Assessing psychological pain is crucial for evaluating suicide risk. This study examined differences in psychological pain between patients with suicide attempts, those with suicidal ideation, clinical, and non-clinical controls using a newly translated German version of the Mee-Bunney Psychological Pain Assessment Scale (MBPPAS). Method: A cross-sectional study was conducted with two i
Lagen (1982:80) om anställningsskydd (LAS) genomgick år 2022 en reform som bland annat innebar en förändring av regleringen för uppsägning på grund av personliga skäl i 7 § LAS. Syftet var att öka förutsebarheten för både arbetsgivare och arbetstagare vid uppsägningar. Med hjälp av rättsdogmatisk metod syftar uppsatsen till att analysera och kartlägga reformen i förhållande till uppsägning på gruThe Employment Protection Act (LAS) underwent a reform in 2022 which, among other things, involved a change in the regulation regarding dismissals on personal grounds in Section 7. The purpose of the reform was to increase predictability for both employers and employees in cases of dismissals. Using a legal dogmatic method, the thesis aims to analyse and map the reform in relation to dismissal on
The ESS linac is under construction by the ESS partner institutes (socalled In-Kind Contributors - IKC) and will operate the most powerful proton beam ever for neutron spallation source. The linac delivers 5 MW via 2 GeV protons at a repetition rate of 14 Hz at the He-cooled solid tungsten target. The pulsed neutrons, result of the spallation, will reach the science instruments after having been m
ObjectivesPeople with serious illness approaching end of life often end up in emergency and hospital care, frequently against expressed preferences. Consequently, oncology trials record care days as a measure of treatment burden called “time toxicity.” However, this measure ignores the diminishing marginal utility of time: that the value of a day is higher when fewer remain. We aimed to incorporat
Growing evidence of the microbiome's importance for plant ecology highlights the need for conservation strategies that consider both plants and their microbial partners, the holobiont. Population genomics are valuable tools for designing conservation strategies but rarely accounts for host- or site-specific microbial interactions. Orchids, with their dependence on specific mycorrhizal fungi, exemp
Introduction: Suicidal behavior results from a complex interplay of psychiatric, psychosocial, socioeconomic, and structural factors and requires coordinated approaches across care sectors. Interprofessional collaboration (IPC) is widely regarded as essential for bridging gaps in care, yet profession-level descriptions of how IPC is organized and where structural bottlenecks occur in suicide preve
This chapter unpacks the complex and contested nature of ‘irregular labour migration’ and explores the meaning and analytical rigour of this conceptualisation. We discuss four social positions: 1) authorised migrant regular worker, 2) authorised migrant irregular worker, 3) unauthorised migrant irregular worker and 4) unauthorised migrant regular worker. Using the distinctions between informalisat
The term smart grid refers to an electrical grid system that incorporates a range of operating and energy initiatives including advanced metering, intelligent distribution boards and circuit breakers, load control switches and smart devices, and renewable energy resources. The incorporation of the internet of things (IoT) into the smart grid, called the internet of energy things-smart grid (IoET-S
ObjectivesBeing met with empathy increases information sharing, treatment coherence, and helps patients to recover faster. However, we do not know how the content of the conversation about disease progression, new treatments, or other issues concerning serious illness affects patients' perceptions of the physician's empathy, and thus, the quality of the conversation. This study aimed to test the h
A method that could assess the whole vehicle non-exhaust particle (NEP) emission from the whole vehicle level was proposed by combining sealed housing with the chassis dynamometer. The intake and exhaust systems were connected to the out of the chamber to avoid possible effects on NEP emissions. The most distinguishing feature of the proposed method is the whole vehicle assessment of the NEP. Base
The effects of operational and environmental variability have been posed as one of the biggest challenges to transit structural health monitoring (SHM) from research to practice. To deal with that, machine learning algorithms have been proposed to learn from experience based on a reference data set. These machine learning algorithms work well based on the premise that the basis of the reference da
The chapter discusses the importance of the EU continuing to promote improved living and working conditions for its citizens without simultaneously risking competition between workers from different member states. The problem discussion is based on the significance of social improvements for the EU to maintain support among citizens and the challenges that arise when EU law encounters the differen
Vid biblioteken i Burlöv och Ängelholm har tidigare bedrivits projekt att främja folkbibliotekens utveckling mot kulturhus (Kulturnämnden 2012). Arbetet med projekten, Kulturhusprojektet i Arlöv och Kulturstråket i Ängelholm, följdes i en studie av författaren och har rapporterats tidi-gare (Rivano Eckerdal 2013). Föreliggande rapport är resultatet av en uppföljande studie som be-dri¬vits under år
In order to reduce the vibration transmission in multi-storey wood buildings, it is common to insert viscoelastic elastomer materials between parts of the buildings. The studies presented here investigate to which extent different design choices for the elastomer layers affect the isolation of low-frequency vibrations (0-100 Hz). A finite element model of two storeys of a multi-storey wood buildin
