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Background Formation of an HIV-1 particle with a conical core structure is a prerequisite for the subsequent infectivity of the virus particle. We have previously described that glycineamide (G-NH2) when added to the culture medium of infected cells induces non-infectious HIV-1 particles with aberrant core structures. Results Here we demonstrate that it is not G-NH2 itself but a metabolite ther
BACKGROUND: The objective of this study was to investigate the relationship between history of induced abortion and preterm delivery in various parts of Europe, and according to the main cause of preterm birth. METHODS: We used data from a case–control survey, the EUROPOP study; 2938 preterm births and 4781 controls at term from ten European countries were included. Based on national statistics, w
Rotational Raman linewidths calculated from three different models have been used in temperature measurements by rotational coherent anti-Stokes Raman scattering (CARS)—a semiclassical ab initio model, the modified exponential energy gap model (MEG), and the energy corrected sudden scaling law (ECS). Experimental rotational CARS spectra were generated, using the dual-broadband approach, in pure ni
The annual fixation of dissolved Si (DSi) into terrestrial vegetation has been estimated to range from 60 to 200 Tmole, or 10-40 times more than the yearly export of DSi and biogenic Si (BSi) from the terrestrial geobiosphere to the coastal zone. Ecosystems form a large filter between primary mobilization of DSi from silicate weathering and its eventual export to the oceans, and a large reservoir
Biotite, muscovite and vermiculite were treated in HCl and H2SO4 solutions at pH ranging between 7 and 1. The solid residue was studied using Mossbauer spectroscopy at room temperature. The spectra of the untreated samples, D0Bio, D0Mus and DOVer were fitted assuming quadrupole splitting distribution, QSD. Different fitting models with different combinations of Gaussian components for the Fe sites
Background: Major depression is often associated with disturbances in basal biological functions regulated by the hypothalamus. Electroconvulsive therapy (ECT), an efficient anti-depressant treatment. alters the activity of hypothalamic neurons. We have previously shown an increased proliferation of endothelial cells in specific areas of the rat hippocampus in response to electroconvulsive seizure
In one growth retarded and hypoxic fetus, the cerebral and umbilical hemodynamic changes were assessed (by Doppler), daily over 20 days. The fetal brain was investigated by magnetic resonance imaging (MRI) close to the delivery, and because the fetus died at delivery we performed an anatomical study of the fetal brain. The evolution of the fetal hemodynamics (day by day) was interpreted according
Kindling is a model of temporal lobe epilepsy in which repeated electrical stimulations in limbic areas lead to progressive increase of seizure susceptibility, culminating in generalized convulsions and the establishment of a permanent epileptic syndrome. We studied here the effect of stimulations in the thalamic reticular nucleus (TRN) on. the development of seizures and hippocampal hyperexcitabi
It is an undeniable fact that software project managers need reliable techniques and robust tool support to be able to exercise a fine control over the development process so that products can be delivered in time and within budget. Therefore, managers need to be trained so that they could learn and use new techniques and be aware of their possible impacts. In this context, effective learning is a
OBJECTIVE: Cardiotocography plus automatic ST analysis of the fetal electrocardiography has been shown recently to reduce both the operative delivery rate for fetal distress and the cord artery metabolic acidosis rate. The purpose of this study was to analyze findings that were related to cases with a complicated/adverse neonatal outcome in the Swedish randomized controlled trial. STUDY DESIGN: Of
Huntington’s disease (HD) is a neurodegenerative disorder caused by expansion of a polyglutamine tract in a protein called huntingtin. The inducible form of heat shock protein 70 (Hsp70) has been shown to reduce polyglutamine-induced toxicity. To investigate if overexpression of Hsp70 can affect disease progression in a mouse model of HD, we crossed R6/2 mice, expressing exon 1 of the HD gene with
Matriptase is a type II transmembrane protease which is characterized by an N-terminal transmembrane and multiple extracellular domains, in addition to the conserved extracellular serine protease catalytic domain. The expression pattern of matriptase suggests that this protease may play broad roles in the biology of surface lining epithelial cells. In this study we report that alpha1-antitrypsin (
OBJECTIVES--Exposure-response relationships in the formation of specific antibodies to hexahydrophthalic anhydride (HHPA) was studied in exposed workers. METHODS--The relation between exposure to HHPA and the levels of specific immunoglobin E [(radioallergosorbent test (RAST)] and immunoglobin G (enzyme-linked immunosorbent assay) antibodies was investigated in a cross-sectional study on 95 worker
Because low genetic diversity may threaten the viability of isolated populations, conservation biologists have devoted much effort to quantify genetic variation. Two techniques routinely used involve levels of mini- and microsatellite polymorphism, with the assumption that levels of variation at these parts of the genome will be reflected in levels of variation at other loci. Our data challenge th
