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Mycobacterium marinum promotes mitochondrial degradation in an ESX-1 dependent manner

Investigating the role of mitochondrial damage in a Tuberculosis infection Tuberculosis (TB) is a significant health risk that was responsible for 10.4 million infections and 1.8 million deaths in the year 2015 alone. The causative agent for TB is Mycobacterium tuberculosis (Mtb), which is an intra-cellular bacterium that primarily replicates within the white blood cell called the macrophage. To

Towards single Ce ion detection in a bulk crystal for the development of a single-ion qubit readout scheme

Popular Abstract in English At the beginning of 20th century, scientists started to realize that atoms exhibited the discrete behaviour, e.g. the energies of bond electrons were not continuously distributed, but had discrete values. Light is also transmitted as discrete packages (called photons). These phenomena can not be explained by classical physics, which has been accepted as the law of descrThe work presented in this thesis was concerned with investigating the relevant spectroscopic properties of Ce ions randomly doped in an Y2SiO5 crystal at low temperatures (around 4 K), in order to develop a technique and an experimental set-up to detect the fluorescence photons emitted by a single Ce ion. The aim of the work was to determine whether a single Ce ion (referred to as the readout ion

Capacitive Biosensor - A Tool for Ultrasensitive Analysis : Application in Clinical Analysis and Process Monitoring

Popular Abstract in English A biosensor is an analytical device that combines a transducer with a biological sensing element. This sensor is unique and has played an important role for a broad range of applications including clinical analysis and process monitoring. Between different types of biosensors, the capacitive biosensor has recently gained a lot of interest due to its analytical performanIncreasing demands for highly sensitive, accurate, fast and portable analytical assays have led to the development of new analytical tools. The integration of highly specific biological sensing elements and appropriate transducers has enabled design of even more efficient biosensor devices for the detection of target substances. In a clinical setting, early detection of biomarkers is crucial for

ICT, learning and the potential of androgynity

Baylor and collaborators have demonstrated (Baylor & Plant, 2005; Baylor et. al., 2006) that the use of virtual pedagogical coaches portrayed as young and attractive women can increase the willingness of female students to apply for technical education and to help increase their selfefficacy. Pedagogical processes such as role modelling and identification seem to be involved (cf. Bandura, 1977

Spray-dried porcine plasma and yeast derived protein meal influence the adaption to weaning of primiparous and multiparous sow progeny in different ways

Pigs from 154 litters (n = 1132, 19 +/- 3 days of age, 4.9 +/- 1.1 kg of bodyweight) were used in a 3 x 2 factorial design to evaluate two raw materials with nutraceutical properties being used in feeds, spray-dried porcine plasma (SDPP) and a yeast protein meal, and their effects on growth performance, immune parameters and gastrointestinal adaption of piglets to weaning. Factors included dietary

Passive houses in Sweden - Experiences from design and construction

The sector of residential buildings and service organizations uses 36% of the total energy in Sweden. In June 2006, it was decided by the Swedish parliament that the energy use in residential buildings and premises should decrease by 20% per heated unit area before 2020. To reach this goal, more energy efficient buildings must be produced as well as energy efficient improvements must be performed

Making 21st Century Maps Legible - Methods for Measuring and Improving the Legibility and Usability of Real-Time Maps

Popular Abstract in Swedish Populariteten av karttjänster, t.ex. på Internet, ökar ständigt. Detta beror till stor del på en hela tiden förbättrad teknik och ett ökande antal idéer för kartapplikationer. Exempel på kartapplikationer är: positioneringstjänster, navigationstjänster, och tjänster för att söka efter, titta på och ladda ner geografiska data och kartor. Kartorna i dessa tjänster skapas The research presented in this thesis has focused on methods for improving the legibility and usability of maps in real-time map services. The aim has been threefold: to create methods to increase the cartographic quality of maps in map services, to develop methods to measure the legibility, as perceived by the user, and to evaluate the quality of maps. Map services are becoming increasingly commo

Labour Productivity in the Building Industry – Studies of Uganda

Research has been pointing out that productivity in the building industry is stagnant and in some cases declining. Poor productivity of craftsmen is one of the causes of cost and time overruns on building projects. Productivity of labour is particularly important especially in developing countries where most of the building work is still carried out on manual basis. The objective of this research

When comes the sun? A study of stakeholders, driving forces and future scenarios of solar power in Sweden.

Background: In order to decouple from carbon dioxide, alternative, renewable energy sources need to replace traditional fossil fuels. The fastest growing renewable technology has for the past years been solar, more specifically in the form of photovoltaics (PV). With the support of policy schemes, solar systems are being installed on rooftops of private houses and corporations - and are incre

TaxSeedo: An energy-saving ANI alternative for rapid classification of bacteria

An energy-saving tool for rapid classification of bacteria When attempting to describe the characteristics of specific bacteria, it is important to know what species is under investigation. The 16S rRNA marker gene is generally used to classify bacteria into existing taxonomical hierarchies. However, a large percentage of the bacterial genome is left unconsidered as the ~1,500 bp of the 16S rRNA

Ivö besökscentrum

Mellan Kristianstad och Bromölla finns Ivö, Skånes största ö som i nuläget är okänt utanför närområdet. På öns norra spets reser sig en urbergskulle 134 meter över havet, så kallad Ivö Klack. Området är idag ett naturreservat, med en rik historia av mytologier, torparlämningar, unika fossilfynd, gammal bokskog och industrilämningar från när Ifö-verken, keramikindustrin, utvann sin råvara på ön. IBetween Kristianstad and Bromölla is Ivö, Skåne's largest island, which is currently unknown outside the region. On the northern tip of the island, a primary rock rises 134 meters above sea level, so-called Ivö Klack. The area is today a nature reserve, with a rich history of mythologies, croft remains, unique fossil finds, old beech forest, and industrial remains from when Iföverken, the cera

Flexibility in emerging e-methanol production in Sweden - An assessment & case study of technical and economic flexibility potential

Som en del i klimatomställningen av svåråtkomliga sektorer som sjöfart, flyg, och kemiindustri kan elektrobränslen komma att spela en viktig roll. I Sverige har e-metanol väckt intresse, och flera produktionsanläggninar är planerade eller under byggnation. Dessa kommer att vara stora elkonsumenter, men på grund av den traditionellt icke-flexibla metanolsyntesprocessen finns det frågetecken kring hAs a part of the climate transition of hard-to-abate sectors such as shipping, aviation, and chemical industry, electrofuels may play a key part. In Sweden, e-methanol has gained interest, and several production facilities are currently planned or under construction. These will be very large electricity consumers, but because of the traditionally inflexible methanol synthesis they may not be able

Investigating The Role Of Tumour Suppressor Genes In Salamander Regeneration And Tumorigenesis Through CRISPR Screens

Looking At Tumour Suppressor Genes Of A Tumour Resistant Species Salamanders like Pleurodeles waltl are tailed amphibians capable of regenerating complex structures like entire organs and limbs. Therefore, they are great models to study the process of regeneration. Regeneration involves cells of the injured tissue going through a lot of growth, division, and migration to reconstruct the original

Betong till 3D-printning - egenskaper i färskt och hårdnat tillstånd

Problemformulering: Byggprocessen är idag långsam, kostsam och genererar stora mängder spill och utsläpp. För att kunna möta bostadsbehovet från den snabbt växande befolkningsmängden måste tekniken utvecklas, den måste bli snabbare och mer kostnadseffektiv. Med ny teknik där betongelement tillverkas genom automatiserad och datorstyrd 3D-printning kan eventuellt hela betongbyggnadsprocessen effektiQuestion formulation: The construction process today is slow, costly and generates large amounts of waste and emissions. In order to meet housing needs of the rapidly growing population in a sustainable way, the technology must evolve; it must be faster and more cost-effective. New technology, where concrete is manufactured by automated and computer-controlled 3D-printing, can possibly streamline

Vattenrening på Örtoftaverket - processvatten, rökgaskondensat och dagvattendammar

Denna rapport beskriver optimering och analysering av Örtoftaverkets vatten till recipient i följande tre områden: • Processvattenreningen, fällning och flockning • Rökgaskondensatet, kvicksilverreduktion • Dagvattendammar, reningsgrad Processvattenreningens fällning och flockning var i behov av intrimning för att öka flockstorleken och –hållfastheten, och på så vis underlätta avskiljningen av meThis report describes the optimization and analysis of the outgoing water to recipient from the heat and power plant Örtoftaverket. The following three areas were investigated: • Process water purification, coagulation and flocculation • Flue gas condensate, mercury reduction • Stormwater ponds, degree of purification The coagulation and flocculation of the process waterwas in need of optimizatio

Current Vaccination Strategies for Prostate Cancer

Context: The first therapeutic cancer vaccine demonstrating effectiveness in a phase 3 study was approved by the US Food and Drug Administration on 29 April 2010. The pivotal trial demonstrated overall survival (OS) benefit in patients treated with antigen-loaded leukapheresis cells compared with a control infusion. Results of other prostate cancer (PCa) vaccination strategies are awaited, as this

Padeliporfin vascular-targeted photodynamic therapy versus active surveillance in men with low-risk prostate cancer (CLIN1001 PCM301) : An open-label, phase 3, randomised controlled trial

Background: Vascular-targeted photodynamic therapy, a novel tissue-preserving treatment for low-risk prostate cancer, has shown favourable safety and efficacy results in single-arm phase 1 and 2 studies. We compared this treatment with the standard of care, active surveillance, in men with low-risk prostate cancer in a phase 3 trial. Methods: This randomised controlled trial was done in 47 Europea

Comparative analysis of root growth modules in HYDRUS for SWC of rice under deficit drip irrigation

Root distribution during rice cultivation is a governing factor that considerably affects soil water content (SWC) and root water uptake (RWU). In this study, the effects of activating root growth (using growth function) and assigning a constant average root depth (no growth during simulation) on SWC and RWU for rice cultivation under four deficit drip irrigation treatments (T90, T80, T70, and T60

Computational modeling of mechanobiology in intact and healing rat Achilles tendon

Tendons fulfill an important musculoskeletal function by enabling energy-efficient force transmission between muscles and bones. The tendon is a collagen-rich connective tissue that adapts to mechanical loading through mechanobiological processes. The tendon contains a hierarchical collagen fiber structure that displays complex mechanical behaviour by storing and dissipating energy. Current unders

Male factor infertility and risk of death : a nationwide record-linkage study

STUDY QUESTION: What is the risk of death among men with oligospermia, unspecified male factor and azoospermia in the years following fertility treatment? SUMMARY ANSWER: No significantly elevated risk was observed among men with oligospermia and unspecified male factor, while an increased risk was found among men with azoospermia. WHAT IS KNOWN ALREADY: Previous studies have shown associations be