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Mammalian metabolism comprises a series of interlinking pathways that include two major cycles: the folate and methionine cycles. The folate-mediated metabolic cycle uses several oxidation states of tetrahydrofolate to carry activated one-carbon units to be readily used and interconverted within the cell, which are required for nucleotide synthesis, methylation and metabolism, particularly for pro

How can cities and communities around the world become more sustainable? What can we do as researchers to help them? As we move through the twenty-first century, these questions assume ever-greater importance. Many of the quickest wins for human and planetary health involve reimagining and reconfiguring cities. Activities that generate negative impacts like air pollution and poor health are concen

Många arbetsgivare känner inte till att de redan idag använder sig av artificiell intelligens, AI, eller annat automatiserat beslutsfattande. Det visar den rapport om AI och risker för diskriminering i arbetslivet som Diskrimineringsombudsmannen, DO, publicerar idag. Att arbetsgivare har denna kunskap är avgörande för att arbeta förebyggande för att motverka diskriminering vid tillämpning av tekni

This chapter begins by providing a general contextualisation of hate speech and the controversies around it. It then asks two questions: Is Holocaust denial a form of hate speech? If the answer is positive, should Holocaust denial be banned?The second section explains what is hate speech. The third section is concerned with the relationship between hate speech and hate crime. The fourth section di

Over the last thirty years, suggestions for how to develop defence capability have developed rapidly. However, supporting theory and structured concept development lag behind. Despite this imbalance, countries need to continuously spend resources on defence development. This study identifies central challenges in relation to the scientific perspectives and approaches needed to support the developm

This chapter discusses the inaugural dissertation of the first ex officio professor of natural law in Denmark, Andreas Hojer: the 1735 Dissertatio iuris publici universalis de eo quod iure belli licet in minores. In doing so, it seeks to shed light on a little-known figure in the early Danish enlightenment, albeit one who was very influential in his day. It explains why Hojer chose what, on the fa

Background: Treatment of common bile duct (CBD) stones after Roux-en-Y gastric bypass (RYGB) poses a particular challenge given the altered anatomy and inability to perform a standard endoscopic retrograde cholangiogram (ERC). The optimal treatment strategy for intraoperatively encountered CBD stones in post-RYGB patients has not been established. Objectives: To compare outcomes following laparosc

The paper examines and illustrates different trends in relation to historical energy use-related intensities and corresponding CO2 emission trends. The methodology encompasses a decomposition quantitative approach for estimating decoupling trends to energy use and economic and demographic parameters driving CO2 emission levels. The analysis covers both global and regional trends for the period 197

Originally published in two volumes in 1748-9, John Cleland’s Memoirs of a Woman of Pleasure (or Fanny Hill) has long been an underground classic. Because of this underground status, and the prejudicial treatment of literary pornography, Memoirs has never been thoroughly investigated. Above all, insufficient attention has been given to the educational and moral aspects of Cleland’s novel. Cleland’