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Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First,

Background: Nigeria is a major contributor to the global malaria burden. The genetic diversity of malaria parasite populations as well as antibody responses of individuals in affected areas against antigens of the parasite can reveal the transmission intensity, a key information required to control the disease. This work was carried out to determine the allelic frequency of highly polymorphic Plas

Objective. Antileukoproteinase (ALP) is a physiologic inhibitor of granulocytic serine proteases. The present study was undertaken to investigate its therapeutic benefit in an antibody-transfer model of erosive polyarthritis and to elucidate its potential to interfere with immune complex-dependent inflammatory pathways. Methods. Arthritis development was induced in male (BALB/c x B10.Q)F-1 mice by

Complement C2 deficiency (C2D) is associated with immunological diseases and increased susceptibility to invasive infections caused by encapsulated bacteria such as Neisseria menigitidis. In this study we evaluate the immunogenicity of vaccination against N. menigitidis in C2D. C2D patients (n=22) and controls (n=52) were given a tetravalent meningococcal polysaccharide vaccine. Serum bactericidal

Transplantation of allogeneic embryonic neural tissue is a potential treatment for patients with Parkinson's and Huntington's diseases. The supply of human donor tissue is limited, and alternatives such as the use of animal (e.g., porcine) donor tissue are currently being evaluated. Before porcine grafts can be used clinically, strategies to prevent neural xenograft rejection must be developed. Kn

Antimicrobial peptides (AMPs) are evolutionarily ancient molecules. They are essential innate immune response molecules that protect organisms from invading pathogens. Tissue factor pathway inhibitors (TFPI-1 and TFPI-2) C-terminal derived peptides exert host defense mechanisms against microbes. Studies showed that in human plasma, C-terminal TFPI-1 and -2 derived peptides mediate bacterial killin

Small synthetic ligands for protein purification have become increasingly interesting with the growing need for cheap chromatographic materials for protein purification and especially for the purification of monoclonal antibodies (mAbs). Today, Protein A-based chromatographic resins are the most commonly used capture step in mAb down stream processing; however, the use of Protein A chromatography

It has previously been shown that sera from multiparous women have increased levels of anti-idiotypic antibodies specific for anti-HLA molecules. γ-Globulins prepared from these sera may be superior to commercial preparations of intravenous γ-globulin (IVIg) for inhibiting HLA alloimmunization. To test this, F(ab′)2 fragments prepared from either commercial IVIg or from the sera of men or multipar

Introduction: Recent haemophilia treatment advances include new recombinant FVIII (rFVIII) products with improved pharmacokinetic (PK) properties that aim to reduce the burden of prophylaxis. These treatments are commonly referred to as extended half-life rFVIII products (EHL rFVIII). There is no uniform definition of what constitutes an EHL rFVIII. Such a definition would help physicians, patient

Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix. Recently we reported that EDC34, a C-terminal peptide derived from TFPI-2, exerts a broad antimicrobial activity. In the present study, we describe a previously unknown antimicrobial mode of ac

IgA nephropathy (IgAN) and Henoch-Schönlein purpura (HSP) are diseases characterized by IgA deposits in the kidney and/or skin. Both may arise after upper respiratory tract infections, but the pathogenic mechanisms governing these diseases remain unclear. Patients with IgAN (n = 16) and HSP (n = 17) were included in this study aimed at examining whether IgA-binding M proteins of group A streptococ

FRAF21 Franska: Grundkurs i Frankrike Semestre d’automne 2025 Hitta (student)boende i Toulouse Trouver un logement (étudiant) à Toulouse Detta dokument är tänkt som ett stöd för de studenter från Lunds universitet som kommer att åka till Université de Toulouse Jean Jaurès för att läsa franska under höstterminen 2025. Dokumentet innehåller information om hemsidor och länkar som hjälper er att komma

https://www.sol.lu.se/fileadmin/user_upload/sol/aemnen/sektion3/Logement_%C3%A9tudiant_%C3%A0_Toulouse_HT2025.docx - 2026-05-23

Arbetsrehabilitering Efterfrågan på evidensbaserade insatser har ökat markant i Sverige och Individual Placement and Support (IPS) är en av de högst prioriterade psykosociala insatserna i Socialstyrelsens nationella riktlinjer. Utbildningen har gått regelbundet sedan 2012 och fokuserar nu även på Supported Education. Särskild tonvikt i utbildningen kommer att läggas vid implementeringen av IPS i b

https://www.medicin.lu.se/sites/medicin.lu.se/files/uppdragsutbildning_ips_ht_2020.pdf - 2026-05-24

Kära medlemmar i Nordic Network for Narratives in Medicine! Vi hoppas att 2023 börjat bra på alla sätt! Här kommer årets första nyhetsbrev och vi passar på att påminna läsarna om att skicka information till mig (Åsa) som ni tror att era med-medlemmar har intresse av. Har ni tankar kring ett möjligt tema för nästa nordiska nätverksmöte (i Trondheim), mejla gärna Katarina.Bernhardsson@litt.lu.se Art

https://www.medicinsk-humaniora.lu.se/sites/medicinsk-humaniora.lu.se/files/2023-11/Nyhetsbrev%201%20januari%202023.pdf - 2026-05-24