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Background: The dysfunction of hypothalamic-pituitary-adrenal (HPA) axis in major depression includes hyperactivity and reduced feedback inhibition. Atrial natriuretic peptide (ANP) is able to reduce the HPA-axis response to stress and has an anxiolytic effect in rodents and humans. We hypothesized that patients with depression would have an attenuated N-terminal proANP (NT-proANP) response to acu

Background: Stereotactic functional neurosurgery on basal ganglia has a long history and the pioneers are mostly men. We aimed at finding out if there were women who have contributed pioneering work in this field. Methods: The literature was searched to identify women who have been first to publish innovative papers related to human basal ganglia surgery. Results: Six women fulfilling our criteria

Benign fibrous histiocytoma (BFH) is a mesenchymal tumor that most often occurs in the skin (so-called dermatofibroma), but may also appear in soft tissues (so-called deep BFH) and in the skeleton (so-called non-ossifying fibroma). The origin of BFH is unknown, and it has been questioned whether it is a true neoplasm. Chromosome banding, fluorescence in situ hybridization, single nucleotide polymo

Functional imaging studies have revealed that certain brainstem areas are activated during migraine attacks. The neuropeptide calcitonin gene-related peptide (CGRP) is associated with activation of the trigeminovascular system, transmission of nociceptive information and plays a key role in migraine pathophysiology. Therefore, to elucidate the role of CGRP it is critical to identify the regions wi

PURPOSE: To analyze the effect of germline mutations in BRCA1 and BRCA2 on mortality in patients with ovarian cancer up to 10 years after diagnosis.EXPERIMENTAL DESIGN: We used unpublished survival time data for 2,242 patients from two case-control studies and extended survival time data for 4,314 patients from previously reported studies. All participants had been screened for deleterious germlin

Background: Feedback is one of the most significant factors for students’ development of writing skills. For feedback to be successful, however, students and teachers need a common language – a meta-language – for discussing texts. Not least because in science education such a meta-language might contribute to improve writing training and feedback-giving. Purpose: The aim of this study was to exp

Introduction: The study aimed to investigate different aspects of cognition using the Cognitive Assessment Battery (CAB) in community-dwelling older adults aged 85 years. We also investigated the eventual influence of sex on the results and aimed to identify predictors for further cognitive decline after 1 year. Methods: CAB consists of 10 subtests covering the cognitive domains of speed and atten

Objectives: To translate the visual analogue scales (VAS) in the Scleroderma Health Assessment Questionnaire (SSc HAQ) and the Cochin Hand Function Scale (CHFS) and to examine the reliability and validity of the Swedish versions of the instruments. Method: The reproducibility, internal consistency, acceptability, and validity of the instruments were evaluated. Eighty-three consecutive patients par

The aim of this study was to assess the reproducibility of isokinetic and isometric ankle dorsiflexor strength measurements in individuals with post-polio syndrome (PPS). Thirty-one men and women (mean age 63 +/- 7.0 years) with verified PPS, participated in an intra-rater test-retest reproducibility study. Strength of the ankle dorsiflexor muscles in both lower limbs were measured twice, seven da

OBJECTIVES To examine which individual and environmental factors correlate with unmet physical activity need in old age and predict development of unmet physical activity need (the feeling that one's level of physical activity is inadequate and thus distinct from the recommended amount of physical activity) over a 2-year follow-up. DESIGN Observational prospective cohort study and cross-sectional

OBJECTIVE: To examine the risk of prostate cancer in relation to pre-diagnostic serum levels of vitamin D (25OHD(2) and 25OHD(3)), PTH, and calcium. METHODS: Nine hundred forty-three incident prostate cancer cases were identified in the Malmö Diet and Cancer Study cohort, and each was matched with one control using incidence density matching with age as the underlying timescale. We also matche

Purpose: To evaluate patients with central retinal vein occlusion (CRVO) and neovascular glaucoma (NVG) using electrophysiology in order to gain better understanding of visual outcome and risk factors, such as previously diagnosed primary open-angle glaucoma (POAG). Methods: Eighty-three patients (83 eyes) initially presenting with CRVO and examined with full-field electroretinography (ERG) within

Popular Abstract in Swedish Inledning För att kunna sätta in resurser där de behövs bäst, finns det en önskan att kunna förutsäga vilka graviditeter som kommer att bli komplicerade. Vid preeklampsi (havandeskapsförgiftning), tillväxthämning hos fostret samt blodproppssjukdom finns det idag inget säkert sätt att tidigt i graviditeten veta vilka som kommer att drabbas. Denna oförmåga att kunna föruThe aim of this thesis was to improve background knowledge for making a reliable medical evaluation at the first visit of a woman in her 13th gestational week, to the antenatal clinic. We have focused on the prediction and the risk estimation of preeclampsia, intra-uterine growth restriction (IUGR), and thrombosis. The thesis was based on five studies, in which we have evaluated biochemical analy

Popular Abstract in Swedish I denna avhandling har morfologin och kristallstrukturen av epitaxiellt växta nanotrådstrukturer undersökts med hjälp av svepelektronmikroskopi (SEM), transmissionselektronmikroskopi (TEM) och multi-slice (MS) simuleringar. Bland annat har vi funnit att de lamellära tvillingar som ofta observeras i III-V nanotrådar växta i <111>B riktningarna tenderar att begränsas av eIn this work, the morphology and crystal structure of epitaxial semiconductor nanowire structures grown by metal-organic vapour phase epitaxy (MOVPE) are studied by electron microscopy methods. In particular, the three-dimensional structure of nanowires and nanotrees has been characterised by scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM) and multi-sli

Popular Abstract in Swedish Syftet är att utifrån studenters livsberättelser, få kunskap om och förståelse för hur de upplever och hanterar sjuksköterskeutbildningens olika delar med särskilt fokus på spänningsfälten mellan: yrkesexamen ? akademisk examen, högskoleförlagd utbildning ? verksamhetsförlagd utbildning samt huvudämnet omvårdnad ? stödämnet medicinsk vetenskap. Syftet är vidare att få kThe aim of this study is to gain knowledge and understanding of how nursing students experience and manage the different parts of the education. A particular focus is set on the tension between a professional degree and an academic degree, between theoretical and clinical studies, and between the subjects nursing and medical science. Furthermore, the aim is to gain knowledge and understanding of a

There has been an increased focus in society on preparedness for emergency response in recent years. Today there is legislation that requires all Swedish authorities at the local, regional and national levels to prepare for emergency management and response. Since the task is rather new, most authorities are just beginning to address it. How the preparedness process should be designed and integrat

Colonization consists of two parts, a dispersal phase followed by establishment and reproduction at a new site. Dispersal behaviour influences survival and the access to resources and mates of individuals and is thus closely linked to an organism's fitness. The dispersal ability of two collembolan species, Protaphorura armata and Folsomia fimentaria, was determined in a laboratory experiment. The

BACKGROUND: Immunohistochemical staining for tumor-associated proteins is widely used for the identification of novel prognostic markers. Recently, a tissue-conserving, high-throughput technique, tissue microarray, has been introduced. This technique uses 0.6-mm tissue core biopsy specimens, 500 to 1000 of which are brought into a new paraffin array block, which can be sectioned up to 100 times. M

The prescribing of selective serotonin reuptake inhibitors for adolescents is extensive despite the fact that there are few pharmacokinetic (PK), efficacy, safety, or tolerability studies on this group. This study reports the PK findings from two trials in adolescents treated with citalopram (CIT) in naturalistic clinical settings: one retrospective and one prospective. The aim of our study was to

Popular Abstract in SwedishAvhandlingen syftar till att studera svenska föreställningar om USA och det amerikanska och genom dem den svenska självbilden och olika visioner om den svenska framtiden i den offentliga debatten under perioden c:a 1900-1939, då USA var omdiskuterat som en mycket betydelsefull ny nation men ännu inte erkänt som en obestridlig supermakt. Den söker visa hur föreställningarThe aim of this thesis is to study Swedish notions of the USA and of things American and through them the Swedish self-image and the ideas about the Swedish future as seen in public debate in the period c. 1900-1939, when the USA was the subject of a good deal of discussion as an up-and-coming nation of great importance but was not yet recognized as an indisputable super power. It tries to demonst