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Insulin-dependent diabetes mellitus (IDDM) is associated with autoreactivity against GAD but the diagnostic sensitivity (positivity in disease) and specificity (negativity in health) of isoform-specific GAD antibodies have yet to be defined in assay systems suitable for screening large number of samples. One set of IDDM patient (n=10) and control (n=50) standard sera were used to develop quantitat

The loss of p53 induces spontaneous tumors in mice, and p53 mutations are found in approximately 50% of human tumors. These tumors are generally caused by a number of events, including genomic instability, checkpoint defects, mitotic defects, deregulation of transcriptional targets, impaired apoptosis, and G 1 deregulation or a combination of these effects. In order to determine the role of protei

A growing body of research highlights the importance of cognition for prediction of falls in Parkinson's disease (PD). However, a previously proposed prediction model for future near falls and falls in PD, which includes history of near falls, tandem gait, and retropulsion, was developed without considering cognitive impairment. Therefore, by using a sample of 64 individuals with relatively mild P

Most patients with anti-glomerular basement membrane (anti-GBM) disease present with rapidly progressive glomerulonephritis with or without pulmonary haemorrhage; however, there are several variants and vigilance is necessary to make a correct diagnosis. Such variants include overlap with anti-neutrophil cytoplasm antibodies-associated vasculitis and membranous nephropathy as well as anti-GBM occu

Radiological and pathological characteristics of hip osteoarthritis (OA) is joint-space loss due to degradation of articular cartilage. However, patients with early-stage OA do not yet show any radiological signs, which leaves them without diagnosis and treatment. This study evaluates the potential of a novel tool to identify pre-radiographic OA changes based on hip bone morphology. Two statistica

Type 1 diabetes (T1D) is an autoimmune disease associated with the destruction of pancreatic β cells and genetically linked to human leukocyte antigen (HLA) class II DR3-DQ2 and DR4-DQ8 haplotypes. The +49A/G polymorphism of the immunoregulatory cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene is also associated with T1D. Genetic and environmental risk factors precede the onset of T1D, which is char

Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased central gamma-aminobutyric acid (GABA) activity as well as marked increases in autonomic and respiratory responses after intravenous infusions of hypertonic sodium lactate(1-3). In a rat model of panic disorder, chronic inhibition of GABA synthes

How do we defend ourselves against pathogenic microbes and other parasites infecting us? Research on defence against parasites has traditionally focused on resistance-the ability to prevent infection or limit parasite replication. The genetics, physiology, and evolutionary ecology of such traits are now relatively well understood. During the last few years it has been realized that another, concep

Stabilization of beta-catenin by inhibition of its phosphorylation is characteristic of an activation of the canonical Wnt/beta-catenin signaling pathway and is associated with various human carcinomas. It contrasts to an as yet incompletely characterized action of an alternative noncanonical Wnt signaling pathway on neoplastic transformation. The aim of the present study was to test the effects o

Airway infections are known to cause exacerbations of allergy and asthma. Tonsils constitute a primary site for microbial recognition and triggering of the immune system in the airways. Human β-defensins (HBDs) are antimicrobial peptides with an important role in this defense. Our aim was to investigate HBD1-3 in tonsillar tissue and their potential role in allergic rhinitis (AR). Tonsils, obtaine

In Papers One through Six we have investigated the function and integration of “new” neurons – new neurons born from neural stem cells in the adult brain, and new neurons in the sense that they were generated from fibroblasts. Papers One and Two focused on the new neurons generated from neural stem cells in the SVZ and SGZ after pathological insults. We investigated how the newly generated neuron

A 6-cm fresh proximal ileum surgical specimen from a blood group A(1)Le(a-b+) secretor individual was used for stepwise isolation of epithelial cells from villus tip to crypt bottom by gentle washing with ethylenediaminetetraacetic acid-containing buffer. Acid and non-acid sphingolipids were prepared from the epithelial cell fractions and the non-epithelial intestinal residue. Molecular informatio

Microsoft Word - final version thesis.docx     Human  Development  legitimizing  new   institutions  for  sustainability:   The  problem  of  legitimacy  in  Earth  System  Governance     Tobias  Abrahamsson   tobbe.abbe@gmail.com   August  15th,  2011       Supervised  by:  Turaj  Faran   turaj.faran@lucsus.lu.se   A  thesis  submitted  in  partial  fulfillment  of  the  requirements  of  Lund  U

https://www.lumes.lu.se/sites/lumes.lu.se/files/abrahamsson_tobias_thesis.pdf - 2025-12-08

OA Thesis Lund University International Master’s Program in Environmental Studies and Sustainability Science Exploring the Concept of Green Water. Bridging Science and Water Resources Management Thesis submitted in partial fulfilment of the requirements of the Master’s Degree in Environmental Studies and Sustainability Science Author: Olga Agaponova, MPA 222 21 Lund, Sweden E-mail: agaponova@hotma

https://www.lumes.lu.se/sites/lumes.lu.se/files/olga_agaponova.pdf - 2025-12-08

1 Application and Project Plan VMFB19 –Project Work The application must be submitted to oonagh.shannon @med.lu.se 1 Applicant Name*:       Personal code number:       Email:       Phone:       |_| By checking this box I verify that I have read the course syllabus and the course description both found on the homepage and understand the importance of collecting the project plans and reports in a po

https://www.medicine.lu.se/sites/medicine.lu.se/files/vmfb19.apply_.docx - 2025-12-08

Nanoscience for Sustainable Energy HEINER LINKE AND LARS SAMUELSON | NANOLUND Nanoscience is the art of understanding and using the new physical behavior exhibited by very small material components – and it offers a wealth of opportunities to help achieve a sustainable energy supply. This is one of the aims of NanoLund, the Center for Nanoscience at Lund University with more than 200 scientists at

https://www.nano.lu.se/sites/nano.lu.se/files/nanoscience_for_sustainable_energy_2015.pdf - 2025-12-08

Cell-based therapies for Parkinson disease—past insights and future potential NATURE REVIEWS | NEUROLOGY ADVANCE ONLINE PUBLICATION | 1 John van Geest Centre for Brain Repair & Department of Neurology, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Cambridge CB2 0PY, UK (R.A.B.). Wallenberg Neuroscience Center, Division of Neurobiology and Lund Stem Cell Center, Lund U

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_nat_rev_neurol.pdf - 2025-12-08

Trang from VietnamHow did you find out about this programme?"After more than 10 fulfilling years teaching Arts at a University in Vietnam, I found myself yearning to explore the world of industrial design. Despite having a stable job, a loving family, and a comfortable life, there was an inner calling I couldn't ignore. When I confided in a Professor at my former Institute of Design School about m

https://www.lunduniversity.lu.se/lubas/i-uoh-lu-taide/what-trang-says-about-masters-industrial-design - 2025-12-08

This thesis investigates how deforestation is problematized within the European Union Deforestation Regulation (EUDR) and examines its implications for smallholder coffee producers in Rwanda. Drawing on Carol Bacchi’s ‘What’s the Problem Represented to Be?’ approach and postcolonial theory, the study analyzes how regulatory problem representations construct responsibility, knowledge, and complianc

Den svenska straffprocessen bygger på principen om fri bevisprövning, enligt vilken det inte ska finnas några rättsliga begränsningar av vilken bevisning som får läggas fram eller normer för hur denna ska värderas. Principen omfattar även bevisning som åtkommits på ett sätt som strider mot någon lag eller rättighet. Det finns dock situationer där användningen av sådan bevisning kränker rätten tillSwedish criminal procedure is based on the principle that there should be no legal limitations on the admissibility of evidence and no rules governing the evaluation of evidence. The principle equally covers evidence obtained illegally. There are, however, cases where the use of such evidence violates the right to a fair trial as guaranteed by the European Convention on Human Rights. For this reas