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Purpose of review Disturbance of the delicate balance between self-renewal and differentiation in haematopoietic stem cells (HSCs) can lead to both leukaemia and bone marrow failure. The regulation of this balance in HSC biology has been intensely investigated in several model systems, and lately the importance of epigenetic modifications as well as the organization and architecture of chromatin h
We present an algorithm to rearrange the colour chains of dipole showers in the shower process according to the colour amplitudes of a simple matrix element. We implement the procedure in the dipole shower of Herwig and show comparisons to data.
Liposuction, which is a very effective treatment modality to reduce lymphedema, can be performed as soon as the pitting component had been corrected by a phase of initial compression (Figure 1). Just like after conservative treatment, the use of compression garments after liposuction is very important to maintain the outcome.Garments should be prescribed in such numbers so that the edema does not
The wide variety of physical phenomena, such as motion of objects, reaction among chemical substances, electricity flow in a circuit can be described by equations with quantities that vary along time.The rate at which a quantity is changing with respect to its independent variable (time), is represented by its derivative. Thus, these phenomena are modeled by equations with differential variables tAdaptive multistep methods have been widely used to solve initial value problems. These ordinary differential equations (ODEs) may arise from semi-discretization of time-dependent partial differential equations(PDEs) or may combine with some algebraic equations to represent a differential algebraic equations (DAEs).In this thesis we study the initialization of multistep methods and parametrize som
Revisiting the Laval case through a discourse analysis of how it has been portrayed in legal doctrine.
Already during the Romantic period, translation played a key role in the mediation of reform ideas from Britain to the Nordic countries, and many translators of texts aiming at social reform wished to instigate change in their home countries. The focus of the present article is on the way in which Henry Brougham’s programme for popular education, as presented in Practical Observations upon the EduDuring the Romantic period, translation played a key role in the mediation of reform ideas from Britain to the Nordic countries, and many translators of texts aiming at social reform wished to instigate change in their home countries. This article focuses on how Henry Brougham’s programme for popular education, as presented in Practical Observations upon the Education of the People (1825), was mad
A cluster-randomized controlled trial, WorkUp, was conducted for working-aged patients at risk of sick leave or on short-term sick leave due to acute/subacute neck and/or back pain in Sweden. The purpose of WorkUp was to facilitate participants to stay at work or in case of sick leave, return-to-work. The aim of this study was to study whether the WorkUp trial was cost- effective. Patients in the A cluster-randomized controlled trial, WorkUp, was conducted for working-aged patients at risk of sick leave or on short-term sick leave due to acute/subacute neck and/or back pain in Sweden. The purpose of WorkUp was to facilitate participants to stay at work or in case of sick leave, return-to-work. The aim of this study was to study whether the WorkUp trial was cost-effective. Patients in the i
Abstract Parasites that can infect multiple host species are considered to be host generalists with low host specificity. However, whether generalist parasites are better adapted to a subset of their host species remains unknown. To elucidate this possibility, we compared the variation in prevalence and infection intensity among host species of three generalist parasite lineages belonging to the m
Objective: To determine factors associated with orthopaedic surgeons’ decision to recommend total joint replacement (TJR) in people with knee and hip osteoarthritis (OA). Design: Cross-sectional study in eleven countries. For consecutive outpatients with definite hip or knee OA consulting an orthopaedic surgeon, the surgeon's indication of TJR was collected, as well as patients’ characteristics in
Transitioning to renewable energy is an imperative to help mitigate climate change, but such transitions are inevitably embedded in broader socio-ecological and political dynamics. Recent scholarship has focused on these more-than-technological dimensions of energy transitions to help understand their promises and drawbacks. This article contributes to this research agenda by highlighting the impo
Objective: The aim of this study was to analyse differences in clinical presentation in patients with early (< 3 years’ duration) systemic sclerosis (SSc), comparing three age groups according to disease subsets. Method: Cross-sectional analysis of the prospective EULAR Scleroderma Trials and Research database (EUSTAR) was performed. Patients fulfilling preliminary American College of Rheumatology
Objective: The objective is to systematically review the literature on economic evaluations of screening interventions for early diagnosis of dementia disorders.Methods: A systematic search of published economic evaluation studies in English was conducted using specified key words in relevant databased and websites. Data extracted included methods and empirical evidence (costs, effects, incrementaOBJECTIVE: The objective is to systematically review the literature on economic evaluations of screening interventions for early diagnosis of dementia disorders. METHODS: A systematic search of published economic evaluation studies in English was conducted using specified key words in relevant databased and websites. Data extracted included methods and empirical evidence (costs, effects, increment
Is the Armenian Genocide a strictly historical matter? If that is the case, why is it still a topical issue, capable of causing diplomatic rows and heated debates? The short answer would be that the century old Armenian Genocide is much more than a historical question. It emerged as a political dilemma on the international arena at the San Stefano peace conference in 1878 and has remained as such
Article 83(2) TFEU, introduced by the Treaty of Lisbon, confers a power on the EU to harmonise Member States’ legislation to define criminal offences and criminal sanctions. Nonetheless, uncertainty persists as to whether this provision exhaustively determines the EU’s power to adopt criminal law to enforce its policies. The article outlines the core case for viewing art.83(2) TFEU as a lex specia
