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A Molecular Dissection of Mantle Cell Lymphoma - From gene expression analysis to functional evaluation of selected targets

Popular Abstract in Swedish Årligen diagnostiseras cirka 60 000 nya fall av cancer i Sverige (Socialstyrelsen, 2015), och var tredje person beräknas få en cancerdiagnos under sin livstid. Trots stora framsteg inom forskning och utveckling är cancer, näst efter hjärt- och kärlsjukdomar, den vanligaste dödsorsaken i vårt samhälle. Bland de tio vanligaste formerna av cancer hör lymfom, vilket är etMantle cell lymphoma (MCL) is an aggressive form of B-cell lymphoma (BCL) with poor clinical outcome. In this thesis, which is based upon five original papers, different approaches have been used to pinpoint and investigate molecular events that promote MCL tumor growth, progression or resistance to treatment. The aim has been to identify novel targets with the potential to eradicate malignant cel

The Implications of Deregulation & Liberalization on the Logistics Service Industry in Lao PDR

This study analyses the development of the Lao freight logistics sector with a special focus on domestic demand for freight logistics services. Based on empirical data, the study focuses on two main dimensions of the Lao freight logistics sector: (i) the development of a private freight logistics sector since the formulation of the New Economic Mechanism (NEM) that progressively opened the Lao eco

Properties of Discontinuous Bifurcations Solutions in Elasto-Plasticity

Explicit expressions for the spectral properties of the bifurcation problem involving discontinuities for general elastic-plastic materials are presented. It then follows that the classical value of the critical hardening modulus derived by Rice (1976. Proc. 14th IUTAM Congr., Delft, The Netherlands, pp. 207–220, North Holland, Amsterdam.) is, in fact, the only possible one. Furthermore, from the

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To an ever-increasing extent, in scientific investigations of various kinds are data collected, which consists of verbal expressions. They may have been generated through verbal presentations, personal interviews, open questions or written accounts. Therefore, it is not unusual that an investigator is confronted with data collections that appear to be “unstructured” and of an extent that it seems

Addressing smoking during pregnancy:The challenge to start from the woman's view

Popular Abstract in Swedish Kvinnor känner till att det är riskabelt att röka när de blir gravida. Trots detta så slutar bara omkring hälften i Sverige och var tredje kvinna i många andra länder att röka när de blir gravida. Syftet i den här avhandlingen har varit att studera varför det är så svårt för gravida kvinnor att sluta röka. Problemområdet har studerats med olika utgångspunkter; gravida kThe aim of this thesis has been to increase understanding on the process of smoking cessation during pregnancy from the perspective of learning. The smoking pattern before and after pregnancy related to health, Sense of Coherence (SOC) and social issues was studied among all pregnant women in south-east Skåne during the period March 1994 to August 1995. They were asked to fill in a questionnaire d

Enhancement of the immunosuppressive effect of cyclosporin A by ciprofloxacin in a rat cardiac allograft transplanation model

Ciprofloxacin hyperinduces interleukin-2 production in stimulated human and mouse lymphocytes. In this study, an enhanced and prolonged interleukin-2 response was also detected in polyclonally stimulated rat splenocytes in the presence of ciprofloxacin (5–80mgrg/ml) compared to control cells without any antibiotic. Ciprofloxacin was able to counteract the immunosuppressive effect of 10ng/ml cyclos

Captured Countryside? Stability and Change in Sub-national Support for African Incumbent Parties

Many existing accounts of African elections assume that voters base their electoral decisions on cues and incentives that are anchored in highly stable ethnic cleavage structures. Yet several newer contributions to the study of African electoral politics have questioned the ethno-clientelistic voting thesis and highlighted other determinants of vote choice, such as class, ideology and performance