BACKGROUND: Ciclosporin is used as an immunosuppressant in current clinical practice but recent research implies novel indications for the drug, such as neuro- and cardioprotection. The intravenous formulation currently on the market, Sandimmune(®) Injection (Sandimmune(®)), uses Cremophor(®) EL as emulsifying excipient. Cremophor(®) EL is known to cause hypersensitivity reactions in some patients

Active surveillance (AS) is an important yet underutilized strategy to reduce prostate cancer (PCa) overtreatment.

Background Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease. Methods We determined genomewide associations with the presence of aortic-valve calcification (among 6942 participants) and mitral annular calcification (among 3795 participants), as detected by computed tomographic (CT) scanning; the stu

The future evolution of global ice sheets under anthropogenic greenhouse forcing and its impact on the climate system, including the regional climate of the ice sheets, are investigated with a comprehensive earth system model consisting of a coupled Atmosphere-Ocean General Circulation Model, a dynamic vegetation model and an ice sheet model. The simulated control climate is realistic enough to pe

Orthogonal P-wave morphology has previously been described in different populations, but its relation to atrial size has not been studied in detail. In this study, we investigated whether atrial size affects P-wave morphology in athletes, who are known to have different degrees of atrial enlargement.

Contrasting ecological conditions may affect the distribution, abundance and impact of parasites and predators throughout the ranges of hosts and prey. Such patterns are evident on the archipelagos of Hawaii and the Galapagos, which vary in their distribution and abundance of avian parasites within and across islands. Previous research has documented higher intensity of parasitic fly larvae (Philo

Recent design experiments have demonstrated that some proteins can switch their folds in response to a small number of point mutations either directly, in a single mutational step, or via intermediate bistable sequences, which populate two different folds simultaneously. Here we explore the hypothesis that bistable intermediates are more common in switches between structurally similar folds while

Background Therapeutic drug monitoring (TDM) of antibiotics in children is of fundamental importance for effective patient management. The use of dried blood spot (DBS) offers a number of advantages over conventional blood collection. The aim of this study is to develop and validate a method to measure piperacillin/tazobactam in DBS. Results The analysis was performed by using LC-MS/MS operating i

This paper deals with a continuous review inventory system with Poisson demand, in which lateral transshipments are allowed. In case of a shortage at a location, another location acts as a supplier, if it is possible. A common assumption in earlier papers is that transshipments are allowed between all locations. This network configuration may, however, not be the best choice for many reasons. one

Book review

Breast cancer survival is reportedly higher in the US than in Europe. The first worldwide study (CONCORD) found wide international differences in age-standardized survival. The aim of this study is to explain these survival differences. Population-based data on stage at diagnosis, diagnostic procedures, treatment and follow-up were collected for about 20,000 women diagnosed with breast cancer aged

Syftet med uppsatsen var att undersöka om det förelåg något samband mellan ett litet företags leverage och kreativitet och mellan andelen venture kapital av det egna kapitalet och kreativiteten. Teorier inom områdena kreativitet och kapitalstruktur har studerats och denna teoribildning applicerades vid undersökningen. Den metod som valdes för att studera fenomenet kreativitet var dels en kvantitat

Syfte: Syftet med uppsatsen är att undersöka om signaleffekten vid aktieåterköp påverkar aktiekursen i form av en överavkastning i Sverige, på samma sätt som forskningsartikeln av Hackethal och Zdantchouk (2006) visar har skett i Tyskland. Metod: En kvantitativ metod i form av en eventstudie har genomförts för att utreda om det finns en överavkastning i samband med återköp av aktier i Sverige. Vi

Syftet är att beskriva och analysera VBM och BSC samt diskutera möjligheten att integrera dessa. Studien bygger på en kvalitativ metod där teoretiska begrepp inom Value Based Management och Balanced Scorecard analyseras och jämförs med empiriska undersökningar i form av intervjuer. Kombinationen av VBM och BSC resulterar i ett lämpligt styrverktyg för många företag. Det är ingen perfekt kombinatio

Syftet med denna studie är att åskådliggöra och analysera de konsekvenser som IAS 41 medför. Vi avser att uppfylla studiens syfte genom att svara på följande forskningsfråga: Vilka fördelar och nackdelar uppkommer i svensk redovisning då IAS 41 implementeras? För att genomföra studien på ett vetenskapligt sätt har en induktiv/kvalitativ ansats använts. Det empiriska materialet baseras på intervjue

The common literature about strategic alliances offers a very fragmented picture. This thesis gives a theoretical overview on strategic alliances and builds the basis for the following examination of the different dimensions most strategic alliances have. The examination of the different dimensions is the crucial point of this thesis. Here the reader gets a detailed insight into the different dime

En sammanfattning av uppsatsen på maximalt 8000 tecken.

Identification and analysis of key success factors for an entrepreneurial firm to achieve leverage when establishing on a foreign market with a premium consumer product.

Syfte: Att utreda om nordiska aktiers volatilitet förändrats i samband med att de noterat sig på London Stock Exchange, New York Stock Exchange eller NASDAQ Stock Market. Vidare är syftet att se om aktiens korrelation med hemmamarknadens totalindex samt deras respektive branschindex har förändrats efter noteringen utomlands. Metod: Vi har i vår uppsats använt oss av en “event study” där vi har ber