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Early stages of tau pathology and its associations with functional connectivity, atrophy and memory
Visualizing surface redox dynamics in VOx/TiO2 catalysts
Savouring the sea: Production and consumption of future seaweed foods
Current food systems pose one of the greatest health and environmental challenges of the21st century. A systemic shift in the food sector can be accelerated by technologies and innovations,such as seaweed food applications. However, introducing and expanding seaweed as a food resourceinto Western markets comes with several challenges.These challenges include its microbial, chemical, and sensory qu
Sustained and controlled delivery of doxorubicin from an in-situ setting biphasic hydroxyapatite carrier for local treatment of a highly proliferative human osteosarcoma
Inherent Instability or Tipping of the Balance: Populism, Immigration and Liberal Democracies
This chapter investigates how the challenging questions and tensions caused by migrants and their universalist claims for inclusion, have been approached and resolved in liberal democracies. By regarding the development of populism as a real and dangerous political phenomenon that has a significant traction, the chapter asks whether populism adds something new to this approach and resolution. More
Constructing the 'social' in social entrepreneurship : A postcolonial perspective
Localization and dynamic regulation of biogenic amine transporters in the mammalian central nervous system
The monoamines, serotonin, dopamine, norepinephrine, epinephrine and histamine, play a critical role in the function of the hypothalamic- pituitary-adrenal axis and in the integration of information in sensory, limbic, and motor systems. The primary mechanism for termination of monoaminergic neurotransmission is through reuptake of released neurotransmitter by Na+,CI-dependent plasma membrane tran
Spatial representativeness and uncertainty of eddy covariance carbon flux measurements for upscaling net ecosystem productivity to the grid scale
Eddy covariance (EC) measurements are often used to validate net ecosystem productivity (NEP) estimated from satellite remote sensing data and biogeochemical models. However, EC measurements represent an integrated flux over their footprint area, which usually differs from respective model grids or remote sensing pixels. Quantifying the uncertainties of scale mismatch associated with gridded flux
A new and reusable foundation solution for onshore wind turbines
Modern wind turbines are designed to withstand approximately for a lifetime of 20 years [1]. However, a very long design life of 100 years or more can be expected for high-quality concrete foundations. Thus there is a big difference in lifetime between wind turbines and foundations. There is a significant economic benefit of replacing the out-of-date wind turbine with a new turbine of better power
Confronting the ecology of crisis : The interlinked roles of ecosystem-based adaptation and empowerment
Nature-based solutions (NBS) focus on the material functioning of ecosystems as part of a transformative response to societal challenges. NBS represent a growing response to climate change with a range of interventions emerging across the world to address the causes and effects of climate change. The adoption of NBS is claimed to address a range of Sustainable Development Goals, including empowerm
Familial Urinary Bladder Cancer with Other Cancers
Background: Family risks for urinary tract cancers (excluding kidney cancers) are known, but less is known about whether rare urinary tract cancer subtypes are also familial and if urinary tract cancers share familial risk for other (discordant) cancers. Objective: To investigate the impact of family history on urinary tract cancers (International Classification of Diseases version 7 code 181) and
Spatial learning and memory following fimbria-fornix transection and grafting of fetal septal neurons to the hippocampus
The ability of intrahippocampal grafts of fetal septal-diagonal band tissue, rich in developing cholinergic neurons, to ameliorate cognitive impairments induced by bilateral fimbria-fornix transections in rats was examined in three experiments using the Morris water-maze to test different aspects of spatial memory. Experiment 1. Rats with fimbriafornix lesions received either septal cell suspensio
To continue or not to continue? Antipsychotic medication maintenance versus dose-reduction/discontinuation in first episode psychosis : HAMLETT, a pragmatic multicenter single-blind randomized controlled trial
Background: Antipsychotic medication is effective for symptomatic treatment in schizophrenia-spectrum disorders. After symptom remission, continuation of antipsychotic treatment is associated with lower relapse rates and lower symptom severity compared to dose reduction/discontinuation. Therefore, most guidelines recommend continuation of treatment with antipsychotic medication for at least 1 year
Lecticans in Vascular Remodeling of the Pulmonary and Fetal Circulation : Implications for Children with End-Stage Heart Disease
Introduction: Elevated pulmonary vascular resistance (PVR) is observed in both physiological and pathological states. Pulmonary hypertension (PH) is a condition associated with significant morbidity and mortality in neonates and children and curative pharmacotherapy is lacking in most cases. In utero, a high PVR allows for blood to bypass the lungs through the open ductus arteriosus (DA). Vascular
Falls Predict Fractures Independently of FRAX Probability : A Meta-Analysis of the Osteoporotic Fractures in Men (MrOS) Study
Although prior falls are a well-established predictor of future fracture, there is currently limited evidence regarding the specific value of falls history in fracture risk assessment relative to that of other clinical risk factors and bone mineral density (BMD) measurement. We therefore investigated, across the three Osteoporotic Fractures in Men (MrOS) Study cohorts, whether past falls predicted
Integrated approach to investigate groundwater nitrate nitrogen pollution and remediation simulation in Shimabara Peninsula, Nagasaki, Japan
Groundwater is the general source of drinking water in the Shimabara Peninsula, Nagasaki, Japan, and consequently, occurring nitrate nitrogen (NO3-N) pollution in the groundwater is a significant problem. Although various countermeasures have been implemented, nitrate nitrogen concentrations remain serious. Therefore, it is necessary to evaluate effects of different potentially effective counterme
A clinical study of efficacy and safety of the Carry Life UF system in continuous ambulatory peritoneal dialysis patients : protocol for a prospective, multicenter, randomized, crossover study
Background: Carry Life UF is a novel peritoneal dialysis (PD) technology for improved fluid management using steady concentration PD (SCPD). The Carry Life UF treatment starts with a manual peritoneal fill of 1.36% glucose PD fluid, followed by a 5-hour treatment where small amounts of glucose are continuously added to maintain a stable intraperitoneal glucose concentration. A recent in-center cli
Polycyclic aromatic hydrocarbons (PAHs) in men and lactating women in Slovenia : Results of the first national human biomonitoring
In the first national human biomonitoring study in the Slovenian population of adults (18–49 years), including men (n = 297) and lactating primiparous women (n = 304), exposure to polycyclic aromatic hydrocarbons (PAHs) was evaluated. Nine urinary metabolites of four parent PAHs were determined. These included 1-hydroxypyrene (1-OHPYR), 2-hydroxynaphthalene (2-OHNAP), 2-hydroxyphenanthrene (2-OHPH
