Biomarker identification is of utmost importance for the development of novel diagnostics and therapeutics. Here we make use of a translational database selection strategy, utilizing data from the Human Protein Atlas (HPA) on differentially expressed protein patterns in healthy and breast cancer tissues as a means to filter out potential biomarkers for underlying genetic causatives of the disease.

Weak separability is an important concept in many fields of economic theory. This chapter uses Monte Carlo experiments to investigate the performance of newly developed nonparametric revealed preference tests for weak separability. A main finding is that the bias of the sequentially implemented test for weak separability proposed by Fleissig and Whitney (2003) is low. The theoretically unbiased Sw

In this letter we report on high-frequency measurements on vertically standing III-V nanowire wrap-gate MOSFETs (metal-oxide-semiconductor field-effect transistors). The nanowire transistors are fabricated from InAs nanowires that are epitaxially grown on a semi-insulating InP substrate. All three terminals of the MOSFETs are defined by wrap around contacts. This makes it possible to perform high-

The future use of single-molecule magnets in applications will require the ability to control and manipulate the spin state and magnetization of the magnets by external means. There are different approaches to this control, one being the modification of the magnets by adsorption of small ligand molecules. In this paper we use iron phthalocyanine supported by an Au(111) surface as a model compound

This work presents a study of sensor network calibration from time-difference-of-arrival (TDOA) measurements for cases when the dimensions spanned by the receivers and the transmitters differ. This could for example be if receivers are restricted to a line or plane or if the transmitting objects are moving linearly in space. Such calibration arises in several applications such as calibration of (a

The emphasis on the equal and eternal responsibility of subjects of different gender and social positions in M.F. Roos's dialogue books promoted a special combination of radical equality in anthropology and a conservative understanding of society. A Pietist teaching on salvation permeates the Orthodox principles on vocation in such a way, that the vocation to community life as a Christian farmer,

This review with 239 references has as its aim to give the reader an introduction to the kinds of methods used for developing microchip based electrode systems as well as to cover the existing literature on electroanalytical systems where microchips play a crucial role for “none-destructive” measurements of processes related to living cells, i.e., systems without lysing the cells. The focus is on

One of the still open issues for the development of superconducting insertion devices is the understanding of the heat load induced by the beam passage. With the aim of measuring the beam heat load to a cold bore and in order to gain a deeper understanding in the beam heat load mechanisms, a cold vacuum chamber for diagnostics is under construction. We plan to have access with the same set-up to a

Electrogoniometers are prone to crosstalk errors related to endblocks rotation (general crosstalk) and to the characteristics of each sensor (individual crosstalk). The aim of this study was to assess the crosstalk errors due to endblock misalignments and to propose a procedure to compensate for these errors in knee applications. A precision jig was used to simulate pure +/- 100 degrees flexion/ex

This paper is intended to give an overview of the current work of the International Commission on Radiological Protection (ICRP) within the field of medicine and healthcare. The paper focuses on the work carried out in Committee 3. Some views expressed at the ICRP Seminar in Bethesda, USA in October 2011 will also be discussed. Similar and complementary work by other organisatons will also be brie

Autopsy of sudden cardiac death (SCD) in the young shows a structurally and histologically normal heart in about one third of cases. Sudden death in these cases is believed to be attributed in a high percentage to inherited arrhythmogenic diseases. The purpose of this study was to investigate the value of performing post-mortem genetic analysis for autopsy-negative sudden unexplained death (SUD) i

Background: Lithuanian primary health care (PHC) is undergoing changes from the systems prevalent under the Soviet Union, which ensured free access to specialised health care. Currently four different PHC models work in parallel, which offers the opportunity to study their respective effect on referral rates. Our aim was to investigate whether there were differences in referrals rates from differe

Several studies on the use of erythropoietin (Epo) to treat anaemia in patients undergoing cancer treatment have shown adverse effects on tumour control and survival. Experimental studies indicate that this could be linked to an interaction with wound healing processes and not an effect on tumour cells per se. We have previously shown that erythropoietin in combination with surgical trauma stimula

Most emission spectra are characterized by lines of various intensities, a feature making them difficult to probe in their entirety - the limited dynamic range of the detector prohibits the simultaneous observation of both weak and intense spectral features. A further known complication in spectroscopy concerns the generation and detection of stray light, which is an undesired contribution of ligh

To better understand and predict the combustion behavior of methanol in engines, sound knowledge of the effect of the pressure, unburned mixture temperature, and composition on the laminar burning velocity is required. Because many of the existing experimental data for this property are compromised by the effects of flame stretch and instabilities, this study was aimed at obtaining new, accurate d