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Popular Abstract in Swedish Typ 2-diabetes mellitus ökar över hela världen med en trend av minskande debutålder. Sjukdomen är ett komplext natur som kan ses som en rad olika metabola sjukdomar med delvis lika symtom, men med helt olika bakgrundsorsaker. Gemensamt för alla varianter av diabetes är att blodsockret är förhöjt även vid fasta. Typ 2-diabetes kännetecknas av insulinresistens och en progType 2 diabetes mellitus is connected with elevated plasma glucose levels which negatively influence β-cells and cause impaired glucose-stimulated insulin secretion (GSIS). The aim of present thesis was to investigate the impact of long-term hyperglycemia on the pancreatic islet β-cell function. The data showed abnormally increased expression of inducible nitric oxide synthase (iNOS) protein in th

This paper explores the use of multi-agent continuous evacuation modelling for representing large-scale evacuation scenarios at music festivals. A 65,000 people capacity music festival area was simulated using the model Pathfinder. Three evacuation scenarios were developed in order to explore the capabilities of evacuation modelling during such incidents, namely (1) a preventive evacuation of a se

Many extensions of the Standard Model posit the existence of heavy particles with long lifetimes. In this Letter, results are presented of a search for events containing one or more such particles, which decay at a significant distance from their production point, using a final state containing charged hadrons and an associated muon. This analysis uses a data sample of proton-proton collisions at

We describe the characterization of the hydrodynamic properties of anisotropic magnetic nanoparticles using a combination of transmission electron microscopy (TEM) and dynamic as well as depolarized dynamic light scattering (DLS/DDLS). The particles used are nearly monodisperse hematite spindles with an average length of 280 nm and a minor axis of 57 nm, coated with a layer of silica of variable t

Recently, optimal linearly constrained minimum variance (LCMV) filtering methods have been applied to fundamental frequency estimation. Such estimators often yield preferable performance but suffer from being computationally cumbersome as the resulting cost functions are multimodal with narrow peaks and require matrix inversions for each point in the search grid. In this paper, we therefore consid

Emergency endovascular aneurysm repair (eEVAR) for ruptured abdominal aortic aneurysm (rAAA) must be carried out instantly. This requires firm logistics that include the ability to cross-clamp the aorta without delay. The present article focuses on the technique of balloon control of the aorta in eEVAR with aspects on indications as well as the organization of this type of vascular service. Transf

This paper looks at the notion of the body as an interior landscape that is made intelligible through visual representation. It discerns the key figure of the inner corporeal voyage, identifies its main elements and examines how contemporary artists working with performances and installations deal with it. A further aim with the paper is to discuss what kind of image of the body that is conveyed t

Many persons world wide are exposed to cold environments, either indoors for example in cold stores, or outdoors. Cold is a hazard to health and may affect safety and performance of work. Basis for the creation of safe and optimal working conditions may be obtained by the application of relevant international standards. ISO 11079(1)) presents a method for evaluation of whole body heat balance. On

This article studies diary weblogs about involuntary childlessness, focusing on Swedish contemporary weblogs written by heterosexual women. The article suggests that the inability to procreate can be seen as an interruption in the western expectation of a predictable life course, and explores how the weblog authors deal with this interruption. The diary weblog is discussed as a genre and as a form

The measurement of the jet energy resolution is presented using data recorded with the ATLAS detector in proton-proton collisions at root s = 7 TeV. The sample corresponds to an integrated luminosity of 35 pb(-1). Jets are reconstructed from energy deposits measured by the calorimeters and calibrated using different jet calibration schemes. The jet energy resolution is measured with two different

This paper explores the building of entrepreneurial capital from an entrepreneurship and contextual/institutional position. In taking this position, it is possible to understand "entrepreneurial capital" as the content of the process that unfolds when individuals are exposed to certain characteristics of the environment. Drawing on findings from an ethnographically inspired longitudinal case study

During the life cycle of the filamentous bacteria Streptomyces, morphological differentiation is closely integrated with fundamental growth and cell-cycle processes, as well as with truly complex multicellular behaviour that involves hormone-like extracellular signalling and coordination with an extraordinarily diverse secondary metabolism. Not only are the bacterial cytoskeleton and the machineri

PURPOSE: To investigate a wavelet-based filtering scheme for denoising of arterial spin labeling (ASL) data, potentially enabling reduction of the required number of averages and the acquisition time. METHODS: ASL magnetic resonance imaging (MRI) provides quantitative perfusion maps by using arterial water as an endogenous tracer. The signal difference between a labeled image, where inflowing arte

Beta cell function is an important factor in the development of both Type 1 (T1D) and Type 2 (T2D) diabetes mellitus. T1D is characterized by a primary defect in insulin secretion due to the immune-mediated beta cell destruction, however, the more common T2D beside insulin resistance also include impaired beta cell function as a consequence to abnormal glucose homeostasis. Genetic susceptibility i

Binding energy shifts between atomic and solid states have been observed with improved accuracy for All 4f and Ag 3d core levels applying a simultaneous measurement method. Also the 3d photoelectron spectrum and binding energies of free Ag atoms have been observed for the first time. New values determined as free atom to bulk solid shifts deviate considerably from previous estimate for Au but agre

Magnitude squared coherence (MSC) is a useful bivariate spectral measure that finds application in a wide variety of fields. In this paper, we develop a nonparametric Capon-based MSC estimator that utilizes a segmented reformulation of the recently introduced iterative adaptive approach (IAA) to provide high resolution MSC spectrum estimates. The proposed estimator, termed segmented-IAA-MSC (or SI

This article deals with the possibilities for Open Access (OA) publishing for Nordic researchers in law and in the humanities. Fifty-two journal editors answered a survey with questions on publishing in OA journals and on parallel publishing. The results show that the number of journals with a clear OA policy is low though a number of journals make articles freely available on the Internet without

A novel integrated approach to high-accuracy machining with industrial robots is presented in this paper. By combining a conventional industrial robot with an external compensation mechanism, a significantly higher bandwidth of the control of the relative position between the tool and the workpiece can be achieved. A model-based feedback controller for the compensation mechanism, as well as a mid-

Rationale and Objectives. The purposes of this study were to retrospectively identify various etiologies underlying intracranial hemorrhages (ICHs) in term infants aged <2 years and their respective prevalence in this population and to describe the long-term clinical outcomes in these patients. Materials and Methods. A retrospective review of the medical records and computed tomographic studies of

Aim and objectives. This article explores relatives' experiences of receiving soft tissue massage as a support supplement while caring for a dying family member at home. Background. In palliative home care, relatives play an important role as carers to seriously ill and dying family members. To improve their quality of life, different support strategies are of importance. Complementary methods, su