Search results

AIM/HYPOTHESIS: Five subgroups were described in European diabetes patients using a data driven machine learning approach on commonly measured variables. We aimed to test the applicability of this phenotyping in Indian individuals with young-onset type 2 diabetes.METHODS: We applied the European-derived centroids to Indian individuals with type 2 diabetes diagnosed before 45 years of age from the

This chapter concerns disabled people’s experiences of barriers to accessing sexuality. It draws on an analysis of materials produced in ten projects by civil society organisations, including self-advocacy organisations, sexual rights organisations and organisations working on behalf of disabled people. These materials comprise books, handbooks, videos, websites and other online materials, and are

I det här kapitlet granskar jag en typ av forskningsansats där icke-mänskliga enheter anses agera. Det handlar inte om att metaforiskt beskriva exempelvis en berättelse som levande, eller göra ett system eller en struktur till grammatiskt subjekt för att understryka dess makt, utan om att betrakta berättelser och system som aktörer jämställda med människor (och vice versa). I actor-network theory

Cervical cancer is preventable through gynecological screening. To promote participation among non-attending women, self-collected vaginal samples for detection of high-risk human papillomavirus (hr-HPV) is an option. The aims of this study were to investigate the response of self-collected vaginal samples for hr-HPV testing among long-term non-attendees, to explore the attendance at follow-up amo

The aim of this thesis is to investigate the changes in vasoactive intestinal peptide (VIP) and calcitonin gene-related peptide(CGRP) and P2Y6-mediated signaling following experimental subarachnoid hemorrhage (SAH) and transient middle cerebral artery occlusion (tMCAO). VIP and CGRP are among the most powerful vasodilators known to man while P2Y6 mediates strong vasoconstriction in cerebral blood

This paper describes the functional development of the ClimApp tool (available for free on iOS and Android devices), which combines current and 24 h weather forecasting with individual information to offer personalised guidance related to thermal exposure. Heat and cold stress assessments are based on ISO standards and thermal models where environmental settings and personal factors are integrated

There are several challenges that have to be considered in order to reduce the cost of System-on-Chip (SoC) testing, such as test application time, chip area overhead due to hardware introduced to enhance the testing, and the price of the test equipment. In this thesis the test application time and the test infrastructure hardware overhead of multiple-core SoCs are considered and two different pro

This timely collection brings together original explorations of the COVID-19 pandemic and its wide-ranging, global effects on human rights. The contributors argue that a human rights perspective is necessary to understand the pervasive consequences of the crisis, while focusing attention on those being left behind and providing a necessary framework for the effort to 'build back better'. Expert co

Acquisition of irregular verb forms in L2 French: does the L1 of the learners explain the difference ? This study explores L1 effects on the production of subject-verb agreement in number (singular vs. plural) in L2 French. L1 influence has rarely been explored in detail in this context, especially compared to other factors such as input frequency of specific verb forms, singular vs plural entitie

Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal expansion of blood cells. Somatic gene mutations associated with hematologic malignancies detected in hematopoietic cells of healthy individuals, referred to as CH of indeterminate potential (CHIP), have been associated with myeloid malignancies, while mosaic chromosomal alterations (mCAs) have been associated wit

To explore the internal flow distributions and heat transfer mechanism in different types of independent cooling modules for automotive, numerical, and experimental studies were conducted. According to the study, the independent cooling modules with parallel structure, on which the heat exchangers were located separately and close to the inlets, the performance improvement was significant. In addi

Cervical cancer is preventable by screening. In 1967, Sweden introduced a cervical screening program. Screening for high-risk human papillomavirus (hr-HPV), the causative factor of cervical cancer, is more sensitive than cytology and can be performed as a self-sample. Non-attendance to screening is a large risk factor for cervical cancer. Self-samples may improve screening attendance. The aims of

Background: People with inflammatory arthritis (IA) often experience low work ability, and up to 38% lose their jobs during the initial years after the diagnosis of IA. Aim: We explore the perceived challenges at work and identify the need for professional support among Danish people with IA. Materials/methods: Individual explorative interviews based on a hermeneutic approach. We used Graneheim an

Car sharing could support a transition away from private vehicle ownership and use. Attempts to understand participation in car sharing have primarily focused on minor and major disruptions which catalyse change in practices. This paper examines how processes of entering, continuing or exiting car sharing systems unfold in Norway, the Netherlands, Sweden and the UK. Car sharing is conceptualised a

Oxidative addition is the standard process for single-bond activation in transition metal catalysis and it is known to operate for many types of bonds, but challenging σ-bonds e. g. C(sp3)−F and C(sp3)−C(sp3) bonds are the exceptions in this respect. This short review aims at demonstrating how both α- and β-eliminations may be better options for activation of unstrained C−F and C−C single bonds. S

Objective: To delineate the full phenotypic spectrum of BCS1L-related disease, provide better understanding of the genotype–phenotype correlations and identify reliable prognostic disease markers. Methods: We performed a retrospective multinational cohort study of previously unpublished patients followed in 15 centres from 10 countries. Patients with confirmed biallelic pathogenic BCS1L variants w

Importance: Preterm delivery has been associated with future cardiometabolic disorders in women. However, the long-term risks of chronic hypertension associated with preterm delivery and whether such risks are attributable to familial confounding are unclear. Such knowledge is needed to improve long-term risk assessment, clinical monitoring, and cardiovascular prevention strategies in women. Objec