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A comparison of outcomes and dislocation rates using dual articulation cups and THA for intracapsular femoral neck fractures

Total hip arthroplasty for intracapsular femoral neck fractures (FNF) is associated with a greater risk of dislocation. Dual articulation systems in this group of patients may provide better implant stability and a reduced dislocation rate. The aim of our study was to investigate FNF patients treated with dual articulation cups (DAC) and conventional THA and compare their clinical results at four

Analysis of manganese and iron in exhaled endogenous particles

Many full-time welders experience some sort of respiratory disorder e.g., asthma, bronchitis and metal fume fever. Thus, welding aerosols are thought to cause airway inflammation. There is a need for markers of welding aerosols in exposure assessments, and as most welding aerosols contain manganese and iron, these metals may possibly be used as an indicator. We have previously developed a novel no

First molecular identification of Babesia gibsoni in dogs from Slovakia, central Europe.

Canine babesiosis is a severe and potentially life threatening infection. In Europe, Babesia canis is considered to be the most common species responsible for the disease. We report two cases of babesiosis caused by Babesia gibsoni. The polymerase chain reaction, restriction fragment length polymorphism analysis and further sequencing of 18S rRNA gene fragments from blood samples of both dogs reve

Radiation Oncology Safety Information System (ROSIS) - Profiles of participants and the first 1074 incident reports

Background and purpose: The Radiation Oncology Safety Information System (ROSIS) was established in 2001. The aim of ROSIS is to collate and share information on incidents and near-incidents in radiotherapy, and to learn from these incidents in the context of departmental infrastructure and procedures. Materials and methods: A voluntary web-based cross-organisational and international reporting an

Devising a best practice approach to prophylaxis in boys with severe haemophilia: evaluation of current treatment strategies

Data from prospective studies clearly demonstrate the efficacy of prophylactic treatment of haemophilia in reducing joint- or life-threatening bleeding and the associated consequences for quality of life. Debate remains, however, regarding the optimal implementation of prophylaxis. Our aim in this review was to identify a best practice approach to factor replacement prophylaxis in boys with haemop

Topical dsRNA challenges may induce overexpression of airway antiviral cytokines in symptomatic allergic disease. A pilot in vivo study in nasal airways.

Airway challenge with dsRNA is of interest since this agent acts on TLR3 and mimics rhinoviral (RV) infection-induced interferons/cytokines. Contrasting frequent employment of dsRNA in epithelial cell cultures there is no information on effects of dsRNA administered to human airways in vivo. Here we explore effects of nasal dsRNA challenges in subjects with seasonal allergic rhinitis inside and ou

Combined SAXS/UV-vis/Raman as a Diagnostic and Structure Resolving Tool in Materials and Life Sciences Applications.

In order to diagnose and fully correlate structural, chemical, and functional features of macromolecules and particles in solution, we propose the integration of spectroscopy and scattering on the same measuring volume and at the same time in a dedicated sample environment with multiple probes. Combined SAXS/UV-vis and SAXS/Raman information are employed to study the radiation damage effect in pro

Circulating CD1c(+) DCs are superior at activating Th2 responses upon Phl p stimulation compared with basophils and pDCs.

The contributing role of circulating human dendritic cell (DC) populations and basophils in the presentation and augmentation of Th2 responses remains to be determined. The present study aimed at elucidating the functional role of CD1c(+) myeloid DCs (mDCs), CD123(+) plasmacytoid DCs (pDCs), monocyte-derived DCs and basophils in allergen presentation and Th2 activation. By coculturing Phleum prate

Current Options and Future Possibilities for the Treatment of Dyskinesia and Motor Fluctuations in Parkinson's Disease

Dyskinesia and motor fluctuations affect up to 90% of patients with Parkinson's disease (PD) within ten years of L-DOPA pharmacotherapy, and represent a major challenge to a successful clinical management of this disorder. There are currently two main treatment options for these complications, namely, deep brain electrical stimulation or continuous infusion of dopaminergic agents. The latter is ac

SOFC Modeling Considering Electrochemical Reactions at the Active Three Phase Boundaries

Abstract in UndeterminedIt is expected that fuel cells will play a significant role in a future sustainable energy system, due to their high energy efficiency and the possibility to use renewable fuels. A fully coupled CFD model (COMSOL Multiphysics) is developed to describe an intermediate temperature SOFC single cell, including governing equations for heat, mass, momentum and charge transport as

The Phylogenetic Distribution and Evolution of Enzymes Within the Thymidine Kinase 2-like Gene Family in Metazoa

Deoxyribonucleoside kinases (dNKs) carry out the rate-determining step in the nucleoside salvage pathway within all domains of life where the pathway is present, and, hence, are an indication on whether or not a species/genus retains the ability to salvage deoxyribonucleosides. Here, a phylogenetic tree is constructed for the thymidine kinase 2-like dNK gene family in metazoa. Each enzyme class (d

A Bi-enzymatic Convergent Cascade for epsilon-Caprolactone Synthesis Employing 1,6-Hexanediol as a "Double-Smart Cosubstrate'

A bi-enzymatic cascade consisting of a Baeyer-Villiger monooxygenase and an alcohol dehydrogenase (ADH) was designed in a convergent fashion to utilise two molar equivalents of cyclohexanone (CHO) and one equivalent of 1,6-hexanediol as a 'double-smart cosubstrate' to produce epsilon-caprolactone (ECL) with water as sole by-product. The convergent enzymatic cascade reaction reported herein, is per

Microbial-mediated redistribution of ecosystem nitrogen cycling can delay progressive nitrogen limitation

Soil nitrogen (N) availability constrains future predictions of ecosystem primary productivity and carbon storage. The progressive N limitation (PNL) hypothesis predicts that forest net primary productivity (NPP) will decline with age, and that the response of NPP to elevated CO2 will attenuate through time due to negative feedbacks of NPP on the soil N cycle. A central assumption of the PNL hypot

The effect of superhydrophobic wetting state on corrosion protection - The AKD example

Corrosion is of considerable concern whenever metal is used as construction material. In this study we address whether superhydrophobic coatings could be used as part of an environmentally friendly corrosion-protective system, and specific focus is put on how the wetting regime of a superhydrophobic coating affects corrosion inhibition. Superhydrophobic alkyl ketene dimer (AKD) wax coatings were p

Ecology: Save the Baltic Sea.

Abstract in Undetermined Comment: Geoengineering efforts to bring oxygen into the deep Baltic should be abandoned, says Daniel J. Conley

CO2 surface fluxes at grid point scale estimated from a global 21 year reanalysis of atmospheric measurements

This paper documents a global Bayesian variational inversion of CO2 surface fluxes during the period 1988-2008. Weekly fluxes are estimated on a 3.75 degrees x 2.5 degrees (longitude-latitude) grid throughout the 21 years. The assimilated observations include 128 station records from three large data sets of surface CO2 mixing ratio measurements. A Monte Carlo approach rigorously quantifies the th

Optimising transparency, reliability and replicability: annotation principles and inter-coder agreement in the quantification of evaluative expressions

Manual corpus annotation facilitates exhaustive and detailed corpus-based analyses of evaluation that would not be possible with purely automatic techniques. However, manual annotation is a complex and subjective process. Most studies adopting this approach have paid insufficient attention to the methodological challenges involved in manually annotating evaluation - especially concerning transpare