There is still a need for new agents which improve upon the therapeutic index of tiotropium, the current standard of care for many patients with chronic obstructive pulmonary disease (COPD). We examined in patients with COPD the efficacy of single doses of AZD9164, an M(3)-selective muscarinic antagonist, to identify an appropriate dose-range for future studies. COPD patients (n = 28) inhaled AZD9

Abstract Aim: To investigate the risk of small for gestational age (SGA) births in relation to maternal history of cardiovascular disease (CVD) across two generations and additionally to analyse maternal CVD risk based on number of SGA offspring. Methods: We used register data from 1.4 million women and 2.7 million offspring. The outcome measures were risk of being SGA in relation to maternal tota

The relative benefits and harms of hormonal treatment (HT) versus no or deferred HT in patients with nonmetastatic prostate cancer (PCa) relapse after primary curative therapy are controversial.

Primary objective was to identify the (1) relationship of clinical severity of urosepsis with the pathogen spectrum and resistance and (2) appropriateness of using the pathogen spectrum and resistance rates of health-care-associated urinary tract infections (HAUTI) as representative of urosepsis. The secondary objective was to provide an overview of the pathogens and their resistance profile in pa

In this article the initiation, development and nature of the indigenous psychologies are characterized. The psychologies in question are those versions of psychology that are, mostly non-western, critical reactions to mainstream psychological research. The heterogeneous and complex nature of the indigeneous psychologies are high-lighted. The enterprise of building a (psychological) science on the

The radiative lifetime of the 1s2p(1)P state of helium is measured in a two-colour ionization experiment with a 5% accuracy. The state is excited by the 13th harmonic of a tunable 80 ps laser and ionized by a synchronous ultraviolet laser, with a variable time delay. This experiment demonstrates that the high harmonics generated in a jet of rare gas exposed to an intense laser field provide a tuna

This thesis deals with the interplay between education, labor markets and health. It consists of five studies exploiting large-scale administrative datasets from Sweden. The first study asks if health and educational attainment are related within monozygotic twin (MZ) pairs. This is motivated by the literature using MZ twins to estimate the returns to schooling. If a healthier twin tends to get

Abstract Sweden's cultural diversity generates considerable challenges for occupational therapists. The aim of this study was to explore experiences and perceptions of occupational therapists working with immigrant psychiatric clients from the Middle East region. The study included interviews with eight occupational therapists employed in mental health care and working in a variety of settings. Th

The main purpose of this article is to discuss the kinds of mental representations that are required for language to evolve. Firstly, I distinguish between cued and detached representations. A cued representation stands for something that is present in the current external situation of the representing organism, while a detached representation may stand for objects or events that are neither prese

OBJECTIVE: Imaging follow-up (FU) after endovascular aneurysm repair (EVAR) is usually performed by periodic contrast-enhanced computed tomography (CT) scans. This study aims to evaluate the effectiveness of CT-FU after EVAR. METHODS: In this study, 279 of 304 consecutive patients (261 male, aged 74 years (interquartile range (IQR): 70-79 years) with a median abdominal aortic aneurysm (AAA) diamet