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Introduction and Aims: Injecting opioid users are at elevated risk of death. Although liver disease (especially hepatitis C) is common, its impact on mortality is low in active injectors. Because opioid substitution therapy (OST) reduces the risk of death from directly drug related causes, we hypothesised that the proportion of liver-related deaths would increase in subjects receiving OST. We inve
The commissioning and operations planning for the European Spallation Source is currently being defined. It is foreseen that the ESS will begin to deliver beam on target by mid 2019, something which is urging a well structured and thought through plan both for commissioning and operations. In this paper we will discuss the plans for beam physics operational software, priorities and software servic
The European Spallation Source, ESS, uses a linear accelerator to bombard the tungsten target with the high intensity protons beam for producing intense beams of neutrons. The nominal average beam power of the linac is 5~MW with a peak beam power at target of 125~MW. This paper focuses on the beam dynamics design of the ESS linac and the diagnostics elements used for the tuning of the lattice and
This article investigates the informal networks of Member States that are claimed to be the drivers of EU gender and development policy. The aim is to highlight the negotiation strategies used in gender and development negotiations and to link these to network characteristics. I categorise the characteristics of the Nordic and the like-minded groupings, relying on network theory and investigate th
Fusion genes are potent driver mutations in cancer. In this study, we delineate the fusion gene landscape in a consecutive series of 195 paediatric B-cell precursor acute lymphoblastic leukaemia (BCP ALL). Using RNA sequencing, we find in-frame fusion genes in 127 (65%) cases, including 27 novel fusions. We describe a subtype characterized by recurrent IGH-DUX4 or ERG-DUX4 fusions, representing 4%
In this paper we present a two-dimensional framework for analysis of research on standards and standardization and its implications for strategic management. Existing research is organized and analyzed, demonstrating that despite the multifaceted nature of the field, patterns and logics are exposed by applying the suggested theoretical framework - its two analytical dimensions being the level of a
We consider a real-time system of multiple tasks, each task having a plant to control. The overall quadratic control cost is to be optimized. We exploit the periodicity of the task response time, which corresponds to a periodic delay pattern in the feedback control loop. Perturbed periods are used as a tool to find a finite hyperperiod. We present an analytical procedure to design a periodic linea
Environmental humidity influences the fitness and geographic distribution of all animals [1]. Insects in particular use humidity cues to navigate the environment, and previous work suggests the existence of specific sensory mechanisms to detect favorable humidity ranges [2-5]. Yet, the molecular and cellular basis of humidity sensing (hygrosensation) remains poorly understood. Here we describe gen
Alarm pheromones are important semiochemicals used by many animal species to alert conspecifics or other related species of impending danger. In this review, we describe recent developments in our understanding of the neural mechanisms underlying the ability of fruit flies, zebrafish and mice to mediate the detection of alarm pheromones. Specifically, alarm pheromones are detected in these species
Solid fuel fired fluidized bed (FB) boilers are common in combined heat and power (CHP) plants in district heating- and process industry. In this study, utilization of such FB boilers for production of syngas in dual fluidized bed gasifiers and subsequent catalytic biofuel production to substitute natural gas (SNG), methanol (MeOH) and Fischer-Tropsch fuel (FT) has been examined. Based on the hypoSolid fuel fired fluidized bed (FB) boilers are common in combined heat and power (CHP) plants in district heating- and process industry. In this study, utilization of such FB boilers for production of syngas in dual fluidized bed gasifiers and subsequent catalytic biofuel production to substitute natural gas (SNG), methanol (MeOH) and Fischer-Tropsch fuel (FT) has been examined. Based on the hypo
PurposeThe purpose of this paper is to present an experimental study which aims at assessing the potentially misleading effect of graphic elements on food packaging. The authors call these elements potentially misleading elements (PMEs) as they can give customers false expectations. They are either highlighted numerical information (30 per cent fibre, 8 per cent fat, 100 per cent natural […]) or p
Background and purpose — There is a general call for phased introduction of new implants, and one step in the introduction is an early evaluation of micromotion. We compared the micromotion in the Triathlon and its predecessor, the Duracon total knee prosthesis, concentrating especially on continuous migration over 5 years of follow-up. Patients and methods — 60 patients were randomized to receive
This paper presents a straightforward method to convert non-uniformly sampled data to uniform samples in order to be processed by some off-line techniques such as system identification. In such scenarios, we deal with a finite-length measurement sequence. We assume periodic extension of the signals, which results in a simple system of linear equations. Furthermore, we take into account a number of
Funerary poems on animals form a subgenre of the standard epitaph written to commemorate a deceased person. The poet who created the conditions necessary for the establishment of this kind of poetry in Sweden was the queen dowager Hedvig Eleonora’s court poet Erik Lindschöld (1634–1690); his poems mourning the death of the queen’s bitches were presumably composed in the 1670s. These poems constitu
BACKGROUND: Atypical antipsychotics have similar clinical efficacy in the treatment of schizophrenia; variability in their tolerability represents the discerning factor in treatment choices. Sertindole has a relatively good tolerability profile that favours long-term patient adherence and, therefore, is associated with lower rates of relapse and rehospitalization.AIM: A model was developed to comp
Mechanical phenotyping of single cells is an emerging tool for cell classification, enabling assessment of effective parameters relating to cells' interior molecular content and structure. Here, we present iso-acoustic focusing, an equilibrium method to analyze the effective acoustic impedance of single cells in continuous flow. While flowing through a microchannel, cells migrate sideways, influen
Modeling tank losses in a harmonic oscillator by means of an equivalent parallel resistance may lead to an optimistic estimate of phase noise, as recently experienced in a class-D CMOS oscillator. The discrepancy is significant if two conditions are fulfilled: The single-ended portion of the tank capacitance displays a non-negligible loss, and the loop gain of the oscillator is very large; in the
Protein self-assembly is extensively used in nature to build functional biomolecules and provides a general approach to design molecular complexes with many intriguing applications. Although computational design of protein-protein interfaces remains difficult, much progress has recently been made in de novo design of protein assemblies with cyclic, helical, cubic, internal and lattice symmetries.
