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Arzanol, an anti-inflammatory and anti-HIV-1 phloroglucinol alpha-pyrone from Helichrysum italicum ssp microphyllum

An acetone extract of Helichrysum italicum ssp. microphyllum afforded the phloroglucinol alpha-pyrone arzanol (1a) as a potent NF-kappa B inhibitor. Arzanol is identical with homoarenol (2a), whose structure should be revised. The phloroglucinol-type structure of arzanol and the 1,2,4-trihydroxyphenyl-type structure of the base-induced fragmentation product of homoarenol could be reconciled in lig

Local vibrational modes of the oxygen-vacancy complex in germanium

Infrared absorption of n- and p-Ge crystals enriched with O-16 and/or O-18 isotopes was studied after irradiation with 6-MeV electrons. Absorption spectra were measured at 10 and 300 K. Along with known bands characteristic of oxygen-containing defects, new lines at 669, 944, and 990 cm(-1) were detected. These bands are annealed at temperatures of 120-140degreesC; the band at 621 cm(-1), previous

Underdosage of the upper-airway mucosa for small fields as used in intensity-modulated radiation therapy: A comparison between radiochromic film measurements, Monte Carlo simulations, and collapsed cone convolution calculations

Head-and-neck tumors are often situated at an air-tissue interface what may result in an underdosage of part of the tumor in radiotherapy treatments using megavoltage photons. especially for small fields. In addition to effects of transient electronic disequilibrium, for these small fields, an increased lateral electron range in air will result in an important extra reduction of the central axis (

Management of postmenopausal bleeding in Sweden: a need for increased use of hydrosonography and hysteroscopy.

Background. The objective was to determine how postmenopausal bleeding (PMB) is managed in Sweden today, and to relate the findings to a new evidence-based algorithm for the management of PMB. Methods. A questionnaire regarding the role of ultrasound and the use of different endometrial biopsy methods in the management of PMB was sent to all 61 gynecologic departments in Sweden. Results. Fifty-n

The relative importance of olfaction and vision in a diurnal and a nocturnal hawkmoth

Nectar-feeding animals can use vision and olfaction to find rewarding flowers and different species may give different weight, to the two sensory modalities. We have studied how a diurnal or nocturnal lifestyle affects the weight given to vision and olfaction. We tested naive hawkmoths of two species in a wind tunnel, presenting an odour source and a visual stimulus. Although the two species belon

Diagnostic stability in adolescent onset psychotic disorders

The purpose was to examine the long-term stability of a diagnosis of psychotic disorder in adolescence and to focus on diagnostic change over time. A total of 88 patients with a first episode of early onset psychosis (before 19 years) were followed up an average of 10.5 years (range 5.1-18.2) after admission. This report includes the 68 patients who could be traced and interviewed with the Positiv

Particle emissions from district heating units operating on three commonly used biofuels

The aim of this study was to characterise particle emissions from district heating units operating on three commonly used biofuels: forest residues, pellets and sawdust. Boilers used in the three district heating units were of moving grate type, with the maximum thermal output between 1 and 1.5 MW. The measurements were done after multicyclones, the only particle removal devices installed, therefo

Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns

To investigate the phenotype associated with estrogen receptor alpha (ER) expression in breast carcinoma, gene expression profiles of 58 node-negative breast carcinomas discordant for ER status were determined using DNA microarray technology. Using artificial neural networks as well as standard hierarchical clustering techniques, the tumors could be classified according to ER status, and a list of

Systematic Design of Linear Feedback Amplifiers

This work adds a quantitative description of distortion to the structured design method of negative-feedback amplifiers. It constitutes a power-series representation of the feedback amplifier, which may include dynamic (memory) effects, where the design parameters appear explicitly. These results have been incorporated into the systematic design method. It now includes design steps for calculating

Detection of Heart Rate Turbulence Using an Extended IPFM Model

In this study, the IPFM model is extended to account for the presence of ectopic beats and heart rate turbulence (HRT). Based on the model extension, a new approach to characterize HRT is presented based on a set of Karhunen- Loeve (KL) basis functions. The three most significant basis functions possess attractive physiological interpretations which reflect the difference in heart rate prior to th

Comparison between comparative tuberculin and gamma-interferon tests for the diagnosis of bovine tuberculosis in Ethiopia

A study to determine and compare the sensitivities and specificities of the comparative cervical tuberculin (CCT) and gamma-interferon (IFN-gamma) tests for the diagnosis of bovine tuberculosis was conducted on 30 zebu oxen. The results of the tests were compared with the presence of acid-fast bacilli found by bacteriological culturing and histopathological examinations. The sensitivity and specif

Severe Pasteurella multocida infections in pregnant women

We report 2 cases of severe infections due to Pasteurella multocida, both occurring during pregnancy in previously healthy women. Both women had contact with animals (dog and cat) but neither of them had been bitten. Apart from a slight decrease in IgG levels, no immunological defects could be detected. Both women had received oral phenoxymethylpenicillin in the early phase of the disease, but sti

Transient electromagnetic wave propagation in laterally discontinuous, dispersive media

This paper concerns propagation of transient electromagnetic waves in laterally discontinuous dispersive media. The approach, used here, employs a component decomposition of all fields. Specifically, the propagation operator that maps a transverse field on one plane to another plane is specified. Expansion of this mapping near the wave front determines the precursor or forerunner of the problem.