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Binding Characteristics Determine the Neutralizing Potential of Antibody Fragments Specific for Antigenic Domain 2 on Glycoprotein B of Human Cytomegalovirus

Site I of antigenic domain 2 (AD-2) on human cytomegalovirus glycoprotein B (gB) is poorly immunogenic in both man and mouse and knowledge about antibody repertoires reactive with this epitope is thus limited. Here we have characterized a phage display-derived repertoire of antibody fragments specific for this epitope in terms of antigen recognition, fine-specificity, and virus-neutralizing capaci

Gestaltningar av offererfarenheter : Samtal med unga män som utsatts för brott

Popular Abstract in Swedish I denna avhandling analyseras unga mäns vålds- och offerupplevelser. Studien bygger på olika typer av material men det mest centrala underlaget består av samtalsintervjuer med unga män som har blivit utsatta för misshandel eller rån. Sätten på vilka de unga männen talar om sig själva, förövaren, våld och offerskap utgör utgångspunkten för analysen. Inom ramen för samtalIn this dissertation, young men's experiences of being victims of crime are analysed. Several kinds of material are considered in this study, but the primary data consist of informal, tape-recorded interviews with ten young men (17 to 21 year's old) who had been assaulted or mugged. Their accounts of their experiences are analysed using a number of constructionist, interactionist, and narrative pe

Experimental Details of the Stopped Beam RISING Campaign

The RISING (Rare ISotope INvestigations at GSI) project constitutes a major pan-european initiative to study nuclear structure in exotic nuclei. A brief outline of the technical details specific to studies of isomeric decays following relativistic projectile fragmentation reactions is presented.

Isolated 46,XY gonadal dysgenesis in two sisters caused by a Xp21.2 interstitial duplication containing the DAX1 gene.

Context: Testis development is a tightly regulated process that requires an efficient and coordinated spatiotemporal action of many factors, and it has been shown that several genes involved in gonadal development exert a dosage effect. Chromosomal imbalances have been reported in several patients presenting with gonadal dysgenesis as part of severe dysmorphic phenotypes. Results: We screened for

Direct resolution of naproxen on a non-covalently molecularly imprinted chiral stationary phase

A synthetic polymer selective for (S)-naproxen was prepared by molecular imprinting. 4-Vinylpyridine and ethylene glycol dimethacrylate were copolymerised in the presence of the template, (S)-naproxen. The template was extracted from the polymer, leaving specific recognition sites, complementary to the template. The polymer was utilized as a stationary phase in HPLC. Racemic naproxen was efficient

The minimal structure and motion problems with missing data for 1D retina vision

In this paper we investigate the structure and motion problem for calibrated one-dimensional projections of a two-dimensional environment. The theory of one-dimensional cameras are useful in several areas, e.g. within robotics, autonomous guided vehicles, projection of lines in ordinary vision and vision of vehicles undergoing so called planar motion. In a previous paper the structure and motion p

Signal correlation including antenna coupling

Mutual coupling effects between antenna elements on signal correlation are reported. A simple expression is derived to compute the correlation coefficient from the far-field radiation patterns including the characteristics of the propagation environment and the terminating impedance. It is shown that the mutual coupling between closely spatially separated dipoles call lead to increased signal deco

Early ageing in middle-aged men is associated with adverse social factors and increased mortality risk: The Malmö Preventive Project.

Aims: This study examined whether middle-aged men exhibiting markers of early ageing showed a different pattern of social factors, lifestyle, and biological variables compared with controls, and whether early ageing was associated with an increased mortality risk. Subjects and methods: We used a subgroup of 5,722 middle-aged men (mean age 47 years), investigated twice, from the Malmö Preventive Pr

Peptides that regulate food intake - Separable mechanisms for dorsal hindbrain CART peptide to inhibit gastric emptying and food intake

We investigated whether dorsal hindbrain and/or peripheral cocaine- and amphetamine-regulated transcript peptide (CARTp) acts to suppress gastric emptying of a caloric stimulus. Furthermore, effects of dorsal hindbrain CARTp on sucrose consumption and licking microstructure was studied, as well as the possible contribution of corticotropin-releasing factor (CRF) receptors to mediate effects of CAR

Development of Adenoviral Vectors for Studying Hematopoietic Stem Cell Function

Popular Abstract in Swedish Blodet innehåller några av de mest grundläggande komponenterna för mänskligt liv. Med hjälp av hjärtats pumpkraft transporterar röda blodkroppar ut syre från lungorna till de mest avlägsna delarna av kroppen via gradvis tunnare blodkärl. Livshotande blödningar stoppas via blodplättarnas koagulerande förmåga och läkande egenskaper, medan de vita blodkropparna bekämpar inHematopoietic stem cells (HSCs) are defined by their capacity to self-renew and differentiate into all hematopoietic cell lineages. Postnatally, HSCs reside predominantly in the bone marrow and are relatively rare, but important cells because of their therapeutic potential in bone marrow transplantation protocols and in their involvement in the origin of certain leukemias. To study how various gen