The self-assembly of the amyloid β 42 (Aβ42) peptide is linked to Alzheimer's disease, and oligomeric intermediates are linked to neuronal cell death during the pathology of the disease. These oligomers are produced prolifically during secondary nucleation, by which the aggregation of monomers is catalyzed on fibril surfaces. Significant progress has been made in understanding the aggregation mech

Background: Carvone (l-carvone) is a mint-tasting flavour additive that most of us is exposed to and can cause allergic contact reactions. Objectives: To analyse the frequency and the relevance of positive carvone reactions in a dermatitis population. Method: A retrospective analysis of dermatitis patients consecutively tested with carvone from 2017 to 2021. Data were retrieved from the department

This chapter presents the results of a production study with twelve speakers of South Swedish. The results show that South Swedish has so-called two-peak contours in non-utterance-final nuclear accents and in phrase-initial accents (so-called initiality accents). The shape of the two-peak contours is reminiscent of contours reported from East Norway and West Sweden. These results contradict previo

Sialyl-Tn (STn or sialyl-Thomsen-nouveau) is a carbohydrate antigen expressed by more than 80% of human carcinomas. We here report a strategy for ratiometric STn detection and dual-color cancer cell labeling, particularly, by molecularly imprinted polymers (MIPs). Imprinting was based on spectroscopic studies of a urea-containing green-fluorescent monomer 1 and STn-Thr-Na (sodium salt of Neu5Acα2-

This paper presents a production study investigating the frequency of utterance-final rises in South Swedish. These rises are interesting from a dialect typological perspective. Recent findings suggest that South Swedish has two-peak accents utterance medially, whereas previous typologies have assumed only one-peak accents for South Swedish dialects. The South Swedish two-peak accents are similar

Folding two-dimensional graphene around one-dimensional III-V nanowires yields a new class of hybrid nanomaterials combining their excellent complementary properties. However, important for high-quality electrical and optical performance, needed in many applications, are well-controlled oxide-free interfaces and a tight folding morphology. To improve the interface chemistry between the graphene an

This review provides an account of salient research topics in current Swedish research in the field of foreign language (FL) education, with the aim of making locally published work available outside Sweden. A corpus of work on English and other FLs published between 2012 and 2021 has been scrutinized. Focus has been placed on research conducted and disseminated in Sweden, in some cases adding int

The Network Construction problem, studied by Angluin et al., Hosoda et al., and others, asks for a minimum-cost network satisfying a set of connectivity constraints which specify subsets of the vertices in the network that have to form connected subgraphs. More formally, given a set V of vertices, construction costs for all possible edges between pairs of vertices from V, and a sequence S1,S2,…,Sr

The market for partly or fully electrified vehicles is expanding fast. The number of sources and loads that are connected to the vehicles traction voltage systems (TVS) increase and thus also the ElectroMagnetic Compatibility (EMC) requirements on these sources and loads. These requirements should make sure that neither function nor lifetime of any source or load is severely affected by another. T

The ubiquitin (Ub) kinase-ligase pair PINK1-PRKN mediates the degradation of damaged mitochondria by macroautophagy/autophagy (mitophagy). PINK1 surveils mitochondria and upon stress accumulates on the mitochondrial surface where it phosphorylates serine 65 of Ub to activate PRKN and to drive mitochondrial turnover. While loss of either PINK1 or PRKN is genetically linked to Parkinson disease (PD)

The invention of the laser in 1960 gave us the ruby laser, which generally produced chaotic pulses of light. Six years later, in 1966, a concept called passive mode-locking applied to neodymium-glass lasers produced reasonably well-behaving picosecond pulses. This triggered an intense activity, with respect to developing improved laser pulse sources, measurement techniques, and application to chem

Introduction: We investigated amyloid-burden quantification in a mixed memory clinic population. Methods: [18F]Florbetaben amyloid-PET (positron emission tomography) scans of 348 patients were visually read and quantified using the Centiloid (CL) method. General linear models were used to assess CL differences across syndromic and etiological diagnosis. Linear mixed models were fitted to assess th

Fossil-based plastics have become a matter of concern due to their negative environmental impacts such as greenhouse gas emissions and threats to the health of living beings. Alternative polymers derived from sustainable biomass resources have thus become an attractive research field since the last decade. Currently, there is a strong demand in the development of new bio-based polymers with enhanc

In sandy beach systems, the aeolian sediment transport can be governed by the vertical structure of the sediment layers at the bed surface. Here, data collected with a newly developed sand scraper is presented to determine high-resolution vertical grain size variability and how it is affected by marine and aeolian processes. Sediment samples at up to 2 mm vertical resolution down to 50 mm depth we

BACKGROUND: Studies of obesity with or without metabolic aberrations, commonly termed metabolically unhealthy or healthy obesity, in relation to cancer risk are scarce.METHODS: We investigated body mass index (BMI, normal weight/overweight/obesity) jointly and in interaction with metabolic health status in relation to obesity-related cancer risk (n = 23,630) among 797,193 European individuals. A m

Background: A comprehensive assessment of morbidity after allogeneic bone marrow transplantation (BMT) performed in childhood remains understudied. Methods: Seven hundred eighty-nine allogeneic BMT recipients who had survived ≥2 years after BMT performed between 1974 and 2014 at age