Glucocorticoid resistance is commonly observed in depression, and has been linked to reduced expression and/or function of the glucocorticoid receptor (NR3C1 in human, hereafter referred to as GR). Previous studies have shown that GR-mutant zebrafish exhibit behavioural abnormalities that are indicative of an affective disorder, suggesting that GR plays a role in brain function. We compared the br

Det gränslösas slutenhet riktar sig till en kultur- och musikintresserad allmänhet som vill orientera sig om hur det postmoderna påverkar dagens tänkande om musik, men också till den läsare som vill sätta sig in i postmodernistisk teoribildning.

The synthesis of a strontium hexaferrite magnet is studied using in situ synchrotron powder X-ray diffraction (PXRD) with a 16-ms time resolution. The precursor material is cold compacted shape-controlled goethite and strontium carbonate. The time evolution of the phases is modeled with sequential Rietveld refinements revealing that strontium hexaferrite forms within seconds at ≈1173 K. Texture an

The interplay between superconductivity and the Kondo effect has stimulated significant interest in condensed matter physics. They compete when their critical temperatures are close and can give rise to a quantum phase transition that can mimic Majorana zero modes. Here, we have fabricated and measured Al-InSb nanowire quantum dot-Al devices. In the Kondo regime, a supercurrent-induced zero-bias c

OBJECTIVES: To evaluate if ileo-psoas muscle size and visceral adipose tissue (VAT) can predict long-term survival after endovascular aneurysm repair (EVAR). METHODS: Patients who underwent EVAR between 2004 and 2012 in a single centre were included. Total psoas muscle area (TPA), abdominal VAT area, subcutaneous adipose tissue (SAT), and total adipose tissue were measured on the preoperative CT.

Understanding the relation between enzyme domain structure and catalytic activity is crucial for optimal engineering of novel enzymes for lignocellulose bioconversion. Xylanases with varying specificities are commonly used to valorise the hemicellulose arabinoxylan (AX), yet characterization of specific arabinoxylanases remain limited. Two homologous GH5_34 arabinoxylanases, HhXyn5A and CtXyn5A, i

Background: Somatic and germline genetic alterations are significant drivers of cancer. Increasing integration of new technologies which profile these alterations requires timely, equitable and high-quality genetic counselling to facilitate accurate diagnoses and informed decision-making by patients and their families in preventive and clinical settings. This article aims to provide an overview of

Objective: We compared the accuracy of amyloid and [18F]Flortaucipir (FTP) tau positron emission tomography (PET) visual reads for distinguishing patients with mild cognitive impairment (MCI) or dementia with fluid biomarker support of Alzheimer's disease (AD). Methods: Participants with FTP-PET, amyloid-PET, and diagnosis of dementia-AD (n = 102), MCI-AD (n = 41), non-AD diseases (n = 76), and co

Anti-amyloid treatments for early symptomatic Alzheimer disease have recently become clinically available in some countries, which has greatly increased the need for biomarker confirmation of amyloid pathology. Blood biomarker (BBM) tests for amyloid pathology are more acceptable, accessible and scalable than amyloid PET or cerebrospinal fluid (CSF) tests, but have highly variable levels of perfor

Monitoring belimumab concentrations in patients can be a valuable tool for assessing treatment response and for personalizing drug doses. Various assay formats may be used to measure concentrations of therapeutic monoclonal antibodies. A particularly useful format involves the use of anti-idiotype monoclonal antibodies, selected to be highly specific to the antibody of interest. Here, we describe

Objectives: To determine the impact of the COVID-19 pandemic on the incidence rates of infection and islet autoimmunity in children at risk for type 1 diabetes. Methods: 1050 children aged 4 to 7 months with an elevated genetic risk for type 1 diabetes were recruited from Germany, Poland, Sweden, Belgium and the UK. Reported infection episodes and islet autoantibody development were monitored unti

OBJECTIVE To characterize distinct islet autoantibody profiles preceding stage 3 type 1 diabetes RESEARCH DESIGN AND METHODS The T1DI (Type 1 Diabetes Intelligence) study combined data from 1,845 genetically susceptible prospectively observed children who were positive for at least one islet au-toantibody: insulin autoantibody (IAA), GAD antibody (GADA), or islet antigen 2 antibody (IA-2A). Using

Background: Colon capsule endoscopy (CCE) has gained momentum as an alternative modality for the investigation of the lower gastrointestinal tract. Of the few challenges that remain, the comparison and – eventually – matching of polyps at different timestamps leads to the potential for double reporting and can contribute to false-positive findings and inaccuracies. With the impending artificial in

Background: Induced hypothermia post-cardiac arrest is neuroprotective in animal experiments, but few high-quality studies have been performed in larger animals with human-like brains. The neuroprotective effect of postischemic hypothermia has recently been questioned in human trials. Our aim is to investigate whether hypothermia post-cardiac arrest confers a benefit compared to normothermia in la

Context: The intensification and expansion of human activities have caused profound changes in global wetlands and their associated aquatic bird communities. Understanding the mechanisms that drive the spatial assemblages of wetland birds is important for the development of effective conservation and management strategies. Objectives: The overall objective was to evaluate the influence of wetland

Laser-induced thermal grating spectroscopy (LITGS) has been proved for accurate thermometry and measurement of energy transfer processes in molecules. While electronic transitions are often used for excitation in previous LITGS works, here we report laser-induced thermal gratings formed by direct excitation of CO2 with an infrared (IR) laser at wavelength near 2 μm, with which high signal-to-noise

We demonstrate reliable machine-learned tuning of quantum-dot-based artificial Kitaev chains to Majorana sweet spots, using the covariance matrix adaptation algorithm. We show that a loss function based on local tunneling spectroscopy features of a chain with two additional sensor dots added at its ends provides a reliable metric to navigate parameter space and find points where crossed Andreev re

Straw and nutrients retained in soil are crucial for priming effect (PE) and consequently for soil organic matter (SOM) turnover. However, the mechanisms by which carbon (C), nitrogen (N), and phosphorus (P) and their stoichiometric ratios impact microbial communities and regulate the PE intensity remain controversial, particularly in the flooded rice soils. In this work, the PE dynamics and micro

The major driver of the climate and biodiversity crisis is our unsustainable production and consumption patterns, but the need to transition to a circular and resource- efficient economy has not been sufficiently addressed by policymakers. Policies supporting circular industrial transition are still rare, not the least in contrast with the recent momentum gained by green industrial policy in EU an