Regulation of Apoptosis in Hematopoietic Progenitor Cells: Involvement of Different Signaling Pathways
Popular Abstract in Swedish Varje dag bildas ca en biljon nya blodceller i en vuxen person. Eftersom blodceller är relativt kortlivade sker denna nyproduktion ständigt. Alla dessa celler härstammar från en sorts cell, multipotenta blodstamceller. Genom en gradvis mognadsprocess, genereras röda blodkroppar (erytrocyter), vita blodkroppar (granulocyter, lymfocyter och monocyter) och blodplättar (troProliferation, differentiation, and survival of hematopoietic stem cells and multipotent progenitor cells are regulated by cytokines and cell-cell interactions. Kit ligand (KL) and Flt3 ligand (FL) have pleiotropic effects, promotes survival, but are nonredundant. Using myeloid progenitor cell lines and mouse bone marrow-derived Lin- progenitors, we demonstrate that inhibition of phophatidylinosit