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Popular Abstract in Swedish Förr trodde man att de delar av genomet som inte uttrycks till proteiner är oviktiga, eftersom man trodde att det nästan uteslutande är proteinerna som utför de nödvändiga funktionerna i cellen. Man kände till att DNA och RNA innehåller information om hur proteiner ska se ut och när de ska uttryckas, men man kände bara till ett fåtal andra uppgifter som RNA har i cellenThe complex genetics of cancer allows tumors to grow and spread undeterred by the control mechanisms of the cell. The importance of protein-coding genes in tumorigenesis is well established. Recently, microRNAs (miRNAs) have emerge as key regulator of development and cellular processes such as differentiation, cell growth and cell death; processes closely linked to cancer. The aim of this thesis w

Popular Abstract in Swedish Mikroorganismer finns överallt! De klarar av att överleva i extrema miljöer, extrema pH, extrema temperaturer och kan motstå strålning och gift i doser som vi inte skulle överleva. Framförallt klarar mikroorganismer av att överleva i en specifik extrem miljö - människan. Hundratals olika mikroorganismer bor på och i oss, i ett antal som långt överskrider vårt eget cellaMicroorganisms are everywhere! They can tolerate many diverse extreme environments, such as the human body. Even though many of us might associate the word microorganism with infections and disease, most are actually either harmless or even beneficial for us. Those commensals often fight off more dangerous bacteria and might also directly benefit their host. The human skin harbors several differen

Background: Traffic emissions including diesel engine exhaust are associated with increased respiratory and cardiovascular morbidity and mortality. Controlled human exposure studies have demonstrated impaired vascular function after inhalation of exhaust generated by a diesel engine under idling conditions. Objectives: To assess the vascular and fibrinolytic effects of exposure to diesel exhaust g

Sexual coercion is prevalent in sub-Saharan Africa and is a risk factor for unintended pregnancies, sexually transmitted infections and mental health problems. Alcohol consumption patterns have been suggested to be an important factor behind the experience of sexual coercion among university students.

This article highlights the semantic and socio-political meaning of the 'field' as it is used in both academic research and policy practices: as a geographic and material space related to forms of intervention in International Relations (IR), and not as a disciplinary space. We argue that the notion of the field' carries colonial baggage in terms of denoting 'backwardness' and conflictual practice

Background: Dizziness is the most common symptom in elderly patients and has been identified as a risk factor for falls. While BPPV is the most common cause of dizziness among elderly, multisensory deficits is the second, with visual, vestibular and proprioceptive reduced function. Asymmetric vestibular function is overrepresented in elderly persons with hip fractures and wrist fractures and can b

Transcriptional factors of the GntR family regulate numerous physiological and morphological processes in response to the nutrient state of bacterial cells. The number of GntR transcriptional factors in genomes of soil-dwelling actinomycetes is one of the highest among bacteria, reflecting both the large size of their chromosomes and the complex ecological niche that they occupy. However, very lit

In this study, a potentiometric glucose biosensor was fabricated by immobilization of glucose oxidase on to zinc oxide nanowires. Zinc oxide nanowires with 250-300 nm diameters and approximately 1.2 mu m lengths were grown on the surface of silver wires with a diameter of 250 mu m. Glucose oxidase (GOD) was electrostatically immobilized on the surface of the well aligned zinc oxide nanowires resul

Fischer-Tropsch (FT) synthesis is an important process in the manufacturing of hydrocarbons and oxygenated hydrocarbons from mixtures of carbon monoxide and hydrogen (syngas). The reduced iron catalyst reacts with carbon monoxide and hydrogen to form bulk Fe5C2 Hagg carbide (chi-HC) during FT synthesis. Arguably, chi-HC is the predominant catalyst phase present in the working iron catalyst. Deacti

Phosphonated polymers with a well-defined molecular weight, composition, and architecture have been prepared via ring opening metathesis polymerization (ROMP) of diethyl phosphonate norbornene imides at room temperature for the first time. ROMP gave a broad range of phosphonated homopolymers, statistical, diblock and triblock copolymers based on poly(norbornene imide)s with low polydispersity (1.0

Background A minority of patients with adult acute lymphoblastic leukemia who relapse are rescued. The aim of this population-based study was to assess the results of reinduction treatment and allogeneic stem cell transplantation in patients in second complete remission. Design and Methods Between 2003-2007, 76 adults (<66 years) with relapsed acute lymphoblastic leukemia (Burkitt's leukemia exclu

It is now widely accepted that globular cluster red giant branch (RGB) stars owe their strange abundance patterns to a combination of pollution from progenitor stars and in situ extra mixing. In this hybrid theory a first generation of stars imprints abundance patterns into the gas from which a second generation forms. The hybrid theory suggests that extra mixing is operating in both populations a

The overall aim of this thesis was to elucidate fathers’ experience of becoming parents of a pretermborn infant as well as their experience in the years after their infant’s birth. A further aim was to describe the context of neonatal care by investigating trends in outcome during a ten-year period in the southern region of Sweden. In total twenty-one fathers were interviewed at three different ti

We used novel Global Positioning System-based satellite telemetry to reconstruct daily time budgets on travelling days of a long-distance migrant, the Osprey Pandion haliaetus, to reveal how landscape affects migratory performance. We compared daily travel routines between the Ospreys' passage of Europe and the Sahara. In Europe, where feeding habitat is abundant, Ospreys fed both before-after fli

In 1995, Best et al. published a formula for the exact bit error probability for Viterbi decoding of the rate R=1/2, memory m=1 (2-state) convolutional encoder with generator matrix G(D)=(1 1+D) when used to communicate over the binary symmetric channel. Their formula was later extended to the rate R=1/2, memory m=2 (4-state) convolutional encoder with generator matrix G(D)=(1+D^2 1+D+D^2) by Lent

The growth of Mn nanostructures on a 1D grating of silicon nano-ribbons is investigated at atomic scale by means of scanning tunneling microscopy, low energy electron diffraction and core level photoelectron spectroscopy. The grating of silicon nano-ribbons represents an atomic scale template that can be used in a surface-driven route to control the combination of Si with Mn in the development of