Filetype
Dysregulation of alternative splicing is increasingly associated with cancer development and tumor progression. BCL2-associated transcription factor 1 (BCLAF1) is involved in a wide range of biological processes and it is continuously being investigated due to its intricate function in tumorigenesis and drug resistance. In acute myeloid leukemia (AML) cell lines, we identified two distinct, unbala
BACKGROUND: Secondary peritonitis caused by gastrointestinal perforation is associated with significant morbidity and mortality. Effective management includes surgical source control, antibiotic therapy, and intensive resuscitation. The choice between primary abdominal closure (PAC) and vacuum-assisted closure (VAC) in the management of secondary peritonitis remains a subject of debate.METHODS: Th
BACKGROUND: Secondary peritonitis is a serious condition with significant morbidity and mortality. Its management requires emergency laparotomy for source control. Vacuum-assisted closure (VAC) and primary abdominal closure (PAC) are the main strategies for managing the laparostomy after source control. Despite the increasing use of VAC, concerns persist regarding its complications and long-term o
Background: Colophony and its derivatives are common allergens. Contact dermatitis from colophony-containing adhesive tapes for blister prevention has previously been reported among Swedish conscripts. Objectives: To present the investigation of suspected allergic contact dermatitis among Norwegian military personnel exposed to medical adhesive tapes during service. Patients/Materials/Methods: Fou
Introduction: Spasticity may introduce bias in passive range of motion (ROM) measurements in children with cerebral palsy. This study aimed to explore the impact of spasticity on the reliability and potential measurement bias of goniometric assessments of ankle dorsiflexion and knee extension in children with unilateral spastic cerebral palsy (USCP). Methods: Thirty-two children aged 6–17 years wi
First, we present a new algorithm for the single-source shortest paths problem (SSSP) in edge-weighted directed graphs, with n vertices, m edges, and both positive and negative real edge weights. For a positive integer parameter t, in O(tm) time the algorithm finds for each vertex v a path distance from the source to v not exceeding that given by the shortest path from the source to v among the so
Industrial and urban symbiosis (IUS) is promoted as a strategy for advancing circular economy transitions, yet implementation often lags behind expectations. While most research highlights municipalities as facilitators of external partnerships, their internal governance role remains underexplored. The aim of this article is to examine how Swedish municipalities govern IUS within their own adminis
Purpose: This paper investigates how farm advisers can develop their practices beyond facilitating farmers’ legal compliance to mediate between farmers’ and regulatory officials’ knowledge and experience of implementing farm-level legal regulation. Design/methodology/approach: Building on theories of knowledge types and Communities of Practice (CoP), the paper employs a qualitative research design
Massively multidimensional diffusion-relaxation correlation MRI provides detailed information on tissue microstructure by analyzing water populations at a sub-voxel level. This method correlates frequency-dependent tensor-valued diffusion MRI with longitudinal and transverse relaxation rates, generating non-parametric D(ω)-R1-R2-distributions. Traditionally, D(ω)-R1-R2-distributions are separated
Obesity is a key contributor to heart failure, driving increased morbidity, mortality, and healthcare costs. This association is supported by multiple pathophysiological mechanisms and consistent epidemiological evidence, particularly not only in heart failure with preserved ejection fraction (HFpEF), but also in heart failure with reduced ejection fraction (HFrEF). Given the rising prevalence of
Deliverable D3.3 is the result of T3.3 Develop context-enriched operational guidelines for AI research areas.The aim of T3.3 was “to identify and lift overarching ethical concerns by cross-analysing use cases toimplement the bottom-up co-creation of context-enriched non-technical AI ethics guidelines” per AIresearch area (cf. AIOLIA DoA). The AI research areas covered in this deliverable are Gener
Background: Quantitative SPECT in radionuclide-therapy is limited by partial-volume effects (PVEs). The implementation of regional voxels (r.v.), estimating mean activity concentrations in regions directly from projections, offers a promising alternative for the geometry-specification to reduce PVEs. Purpose: This study aims to demonstrate that activity-concentration estimation with r.v. is superi
We realize strongly confined quantum dots (QDs) in InAs nanowires (NWs) by combining epitaxial crystal-phase control with chemical wet etching. A strong axial confinement is first introduced by growing closely spaced wurtzite (WZ) tunnel barriers in NWs to enclose a zinc blende (ZB) QD. The NW cross-section is then reduced by isotropic etching to obtain very small QDs, with a maximum observed char
Monitoring atmospheric CO2 concentration changes across China is crucial for reducing carbon emissions and tackling global warming. Due to monitoring gap in satellite observations, this paper uses the Extremely Randomized Trees (ERT) model alongside OCO-2 satellite data and predictor variables to develop a 0.1° high-resolution monthly dataset of column-averaged dry air CO2 mole fraction (XCO2) in
OBJECTIVES: Early identification of treatment response in brain metastases remains clinically challenging. This study explores tensor-valued diffusion MRI (dMRI), specifically q-space trajectory imaging (QTI), as a novel source of early imaging biomarkers during stereotactic radiotherapy (SRT).METHODS: Twenty-six patients with brain metastases were enrolled; thirteen met quality and completeness c
Computational models play an increasingly vital role in scientific research by enabling the numerical simulation of complex processes. Such models are also fundamental in geosciences. For instance, they offer critical insights into the impacts of global change on the Earth system today and in the future. Beyond their value as research tools, models are also software products and should therefore a
Leafmines found on Genista berberidea Lange in northern Portugal led to the discovery of two new species: Phyllonorycter berberidella Nunes, Laštůvka & Laštůvka sp. nov. (Lepidoptera: Gracillariidae) and Achrysocharoides genistae Hansson sp. nov. (Hymenoptera: Eulophidae). The moth is described based on specimens reared from the host plant, and the wasp from individuals that emerged from the m
Internal crisis communication has long been undervalued compared to external communication, both in research and practice. Traditionally treated as a secondary, information‑driven activity, it is now gaining increased attention. Effective internal crisis communication is crucial not only for managing crises, but also for preventing secondary communication crises, supporting organizational learning
