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The endothelin receptor antagonist atrasentan improved kidney outcomes in the SONAR trial for type 2 diabetes and chronic kidney disease (NCT01858532), though individual responses varied. To identify molecular biomarkers of atrasentan response and outcome, we conducted a nested case-control proteomics study (N = 180) within the SONAR trial population and identified urinary clusterin (uCLU) as the
Introduction: Strengthening Primary Health Care (PHC) is essential for building resilient and equitable health systems, but PHC faces barriers in implementation, resource allocation, and political prioritisation. This study aimed to develop a strategic roadmap to enhance PHC by identifying core values, priorities, and actionable strategies through expert consensus. Methods: A two-round Delphi stud
Globally, a substantial number of children experience various forms of parental maltreatment. Child protection agencies work to support these children and prevent further abuse or neglect, often through targeted interventions directed at the parents. Previous research has indicated that social workers may approach male and female perpetrators of maltreatment differently once a case is reported. To
This article examines the life and work of the Danish Catholic priest Peter Schindler through a biographical and microhistorical perspective. Particular attention is given to Schindler’s memoirs, written during his years at the German priestly college at Campo Santo Teutonico in Rome, where he lived from 1947 to the early 1960s. In these writings, Schindler portrays his residence in Rome as the fu
BACKGROUND: One key element of lung-protective ventilation is the use of a low tidal volume (VT). A sex difference in use of low tidal volume ventilation (LTVV) has been described in critically ill ICU patients.OBJECTIVES: The aim of this study was to determine whether a sex difference in use of LTVV also exists in operating room patients, and if present what factors drive this difference.DESIGN,
A new breed of prophets-intermediaries and pastoral bros of an AI industry with metaphysical aspirations-has surfaced on the global stage during troubled times. They make great promises, offer predictions and warnings, and stake out directions for humanity. This article argues that they do so by invoking the implicit collective memory of the apocalyptic imaginary known from ancient Jewish apocalyp
The resilience performance of networked microgrids (NMGs) in disaster-prone areas, using a real-world testbed located in Lombok, Indonesia is explored in this paper. Given the increasing environmental pressures and energy security concerns in Indonesia, it is vital to improve the robustness and sustainability of decentralized energy infrastructures. We propose an optimization-based energy manageme
This thesis investigates core excited electronic states of molecules in gas phase. In particular, the resonanttransitions of ionised molecules, the site-selectivity surrounding Auger-Meitner decay, and the nuclear dynamicsthat may follow core excitation and ionisation.Background: Fundamental understanding of molecules and ions lay the groundwork for all future applicativescience and production. Fo
Breast cancer is the most common cancer in women. Lymphoedema in the arm is a well-known side effect of breast cancer treatment and ranks high among the serious concerns of survivors. Thus, it is important to diagnose arm lymphoedema at an early stage and start conservative treatment when lymphoedema is still minimal or mild, thereby preventing development or deterioration of arm lymphoedema. Scre
Questions: How did α-, β- and γ- plant diversity of coastal dune slack plant communities change over 37 years during a period of significant changes in conservation management practices?. Location: Ainsdale Sand Dunes National Nature Reserve, England. Methods: We surveyed plant communities in dune slacks at Ainsdale Sand Dunes National Nature Reserve at two time points: in 1985 and in 2022. This p
Digital technology has become an integral aspect of contemporary cities, especially with the rise of smart city initiatives. Over the past two decades, researchers and practitioners have studied the potential of large public screens, also known as urban screens, in transforming public spaces and shaping the urban experience. This article contributes to the debate by discussing urban screens in the
We introduce a two-phase quadratic integrate-and-fire (QIF) neuron whose membrane potential evolves according to two alternating Riccati equations within finite bounds. This simple extension removes the unphysical voltage divergence of the standard QIF model while producing realistic spike waveforms. Despite this modification, the system retains an exact low-dimensional description in the thermody
Objective: Psychiatric comorbidity frequently presents in anorexia nervosa (AN). Yet, the premorbid mental health status is rel-atively unknown. The aim of this study was to map out psychiatric morbidity and psychopathology among girls at familial highrisk (FHR) of developing AN, thereby detecting possible underlying vulnerabilities preceding the disease.Method: Twenty-eight daughters of mothers w
Purpose: Radiotherapy (RT) for patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC) can be intensified by delivering 6 (6fx/w) instead of 5 (5fx/w) fractions per week. Randomized trials have demonstrated superiority for 6fx/w in patients treated without concurrent chemotherapy (CRT). This real-world analysis compares 6 vs 5 fx/w in LA-HNSCC all-comers, treated predominan
Introduction: Out-of-pocket (OOP) healthcare costs remain prohibitive in low-resource settings, often pushing families into poverty. Universal health coverage (UHC) goals emphasise protecting households from financial hardship due to medical expenses. Objectives: This study examines which socioeconomic and demographic factors predict the amount of free mental healthcare support received by applica
This special issue aims to deepen the understanding of the Europeanisation of universities from 1980 to the mid-1990s. By focussing on five universities situated in different European contexts, we aim to provide insight into how Europeanisation has taken place and changed higher education. The geographical diversity and the main differences between universities provide the opportunity to show both
Frits Gåvertsson skriver om moralfilosofins relation till idéer om det goda livet och skiftet från frågan 'hur bör jag leva?' till 'vad bör jag göra i en given situation?'.
