The European Association of Urology Renal Cell Carcinoma (RCC) guidelines panel updated their recommendation on adjuvant therapy in unfavourable, clinically nonmetastatic RCC following the recently reported results of a second randomised controlled phase 3 trial comparing 1-yr sunitinib to placebo for high-risk RCC after nephrectomy (S-TRAC). On the basis of conflicting results from the two availa

Context While vascular endothelial growth factor-targeted therapy and mammalian target of rapamycin inhibition are effective strategies in treating clear cell renal cell carcinoma (ccRCC), the most effective therapeutic approach for patients with non-clear cell RCC (non-ccRCC) is unknown. Objective To systematically review relevant literature comparing the oncological outcomes and adverse events o

Checkpoint blockade of CTLA-4 results in long-lasting survival benefits in metastatic cancer patients. However, patients treated with CTLA-4 blockade have suffered from immune-related adverse events, most likely due to the breadth of the induced T-cell activation. Here, we investigated the efficacy of a local low-dose anti-CTLA-4 administration for treatment of subcutaneous or orthotopic murine bl

Background: The epidemiology of the zoonotic tick-transmitted parasite Babesia spp. and its occurrence in wild reservoir hosts in Sweden is unclear. In European deer, several parasite species, including Babesia capreoli and the zoonotic B. venatorum and B. divergens has been reported previously. The European roe deer, Capreolus capreolus, is an important and common part of the indigenous fauna in

Introduktion:Studiet af performance er i kulturteoretisk sammenhæng karakteriseret ved, at det på én og samme tid peger på et genstandsfelt og på et analytisk perspektiv. Iscenesættelse, materialenærhed, proces, deltagelse, subversion, gentagelse og transformation er ikke kun centrale begreber i forståelsen af performancekunst som felt, men er det også når performanceperspektivet anvendes som anal

Ne clusters (∼5000 atoms) were resonantly excited (2p→3s) by intense free electron laser (FEL) radiation at FERMI. Such multiply excited clusters can decay nonradiatively via energy exchange between at least two neighboring excited atoms. Benefiting from the precise tunability and narrow bandwidth of seeded FEL radiation, specific sites of the Ne clusters were probed. We found that the relaxation

Secondary aerosols formed from anthropogenic pollutants and natural emissions have substantial impacts on human health, air quality, and the Earth's climate. New particle formation (NPF) contributes up to 70% of the global production of cloud condensation nuclei (CCN), but the effects of biogenic volatile organic compounds (BVOCs) and their oxidation products on NPF processes in forests are poorly

The present work addresses critical issues in constructing high suppression, narrowband spectral filters in rare-earth-ion-doped crystals, mainly targeting the application of ultrasound optical tomography but is also applicable for areas such as quantum memories, self-filtering of laser frequencies, and other applications relying on high absorption in rare-earth-ion-doped crystals. The polarizatio

Tolerance is a distinguishing feature of Western culture. Still, it varies between and within countries, as well as over time, and irrespective of whether one values it for its own sake or for its beneficial consequences, it becomes important to identify its determinants. In this study, we investigate whether the character of economic policy plays a role, by looking at the effect of changes in eco

This paper presents a fully automated method for segmentation of 3D SPECT ventilation and perfusion images. It relies on statistical information on lung shape derived by CT manual segmentation and its main processing steps are: shape model extraction, binary segmentation, positioning of mean shape in SPECT images and iterative shape adaptation based on intensity profiles and on what is considered

In the paper we address an important problem in minimum cost design of Elastic Optical Networks (EON), namely the problem of optimizing the configurations of Sliceable-Bandwidth Variable Transceivers (S-BVT) at the EON nodes. We first show how this optimization problem can be viewed and modeled as a combination of three bin-packing subproblems, with additional constraints ensuring feasibility of t

The summer precipitation (June–September) in the source region of the Yellow River accounts for about 70% of the annual total, playing an important role in water availability. This study divided the source region of the Yellow River into homogeneous zones based on precipitation variability using cluster analysis. Summer precipitation trends and teleconnections with global sea-surface temperatures

In this study, an oxygen monitoring system was demonstrated for sensitive oxygen detection. The system is based on tunable diode laser absorption spectroscopy (TDLAS) and wavelength modulation spectroscopy (WMS). Stable 2nd-harmonic signals of oxygen were detected by measuring the oxygen P9 absorption line at 764.38. nm. In the detection, a cubic diffuse integrating cavity was employed as a gas ab

Steep declines in photovoltaic (PV) technology prices have directed attention to the so-called soft costs associated with PV deployment. This paper focuses on one element of soft costs: those that arise from local permitting and inspection processes typically being handled by municipalities. Based on a literature review, the paper compares the status of local PV permitting in the US and Germany. R

Reaction of Ru3(CO)12 with tris(2-thienyl)phosphine (PTh3) in CH2Cl2 at room temperature or in THF in the presence of a catalytic amount of Na[Ph2CO] furnishes the carbonyl substitution products Ru3(CO)11(PTh3) (1), Ru3(CO)10(PTh3)2 (2), and Ru3(CO)9(PTh3)3 (3). Heating 1 in toluene affords the cyclometalated cluster Ru3(CO)9{μ-Th2P(C4H2S)}(μ-H) (4) resulting from carbonyl loss and carbon-hydrogen

The use of plastic scintillation microspheres (PSm) is an innovative technique for measuring the radioactivity of beta-emitting radionuclides. PSm can be produced via different methods; none of which has been assayed at the industrial scale. In the present paper, we evaluate the production of PSm by spray-drying on an industrial scale. Our results indicate that fluorescent solutes were indeed enca

The study investigated subjective theories of dream function (why do we dream)- measured as level of agreement with selected prescientific and contemporary views of science (N = 667) and thus explored differences in dream attitude with respect to age, educational level, and sex. A factor analysis revealed 3 factors. One can be described as seeing dreams as meaningful information processing (memory

Romani chib har talats i Sverige i 500 år. Det är inte ett enhetligt, väldefinierat språk, som man kan skriva en enkel grammatik om. Tvärtom, i Sverige talas en stor mängd väldigt olika varianter av romani chib. Några har talats här länge, andra bara en kort tid.Boken fokuserar på de tre varianter som har talats längst i Sverige: skandoromani, kelderash och kale. Förutom språken behandlar boken ta