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FYN is a non-receptor tyrosine kinase belonging to the SRC family of kinases, which are frequently over-expressed in human cancers, and play key roles in cancer biology. SRC has long been recognized as an important oncogene, but little attention has been given to its other family members. In this report, we have studied the role of FYN in FLT3 signaling in respect to acute myeloid leukemia (AML).
This thesis deals with physical limitations on scattering and absorption of acoustic and electromagnetic waves. A general dispersion relation for the extinction cross section of such waves is derived from the holomorphic properties of the scattering amplitude in the forward direction. The result states that for a given volume, there is only a limited amount of scattering and absorption available i
To identify epigenetic patterns, which may predispose to type 2 diabetes (T2D) due to a family history (FH) of the disease, we analyzed DNA methylation genome-wide in skeletal muscle from individuals with (FH(+)) or without (FH(-)) an FH of T2D. We found differential DNA methylation of genes in biological pathways including mitogen-activated protein kinase (MAPK), insulin, and calcium signaling (P
Symmetrical cell division requires duplication of DNA and protein content to generate two daughter cells. Centrosomes also duplicate during cell division, but the mechanism controlling this process is incompletely understood. We describe an alternative splice form of SadB encoding a short SADB Ser/Thr kinase whose activity fluctuates during the cell cycle, localizes to centrosomes, and controls ce
Kulturartikel om Alfred Histchcocks Psycho och filmens betydelse för att förändra skräckfilmsgenren.
Squamous cell carcinoma (SCC) of the skin is a tumor with greatly increased incidence among immunosuppressed patients; therefore, an infectious cause of SCC has long been sought. We performed a hospital-based case-control study of Staphylococcus aureus and biopsies of SCC (n = 82), basal cell carcinoma (n = 142), actinic keratosis (n = 57), and seborrhoeic keratosis (n = 72) in comparison with bio
Objective: The long-term suicide risk of depression was evaluated in a community sample by severity and gender. Method: The Lundby study is a prospective, longitudinal cohort study on a population consisting of 3563 subjects. In 1947-1997 medium or severe depression according to the Lundby diagnostic system were registered in 503 subjects. The same subjects were also diagnosed according to DSM-IV
Accurate determination of line parameters from weak absorption using two-tone frequency-modulation spectroscopy (TTFMS) with a GaAlAs diode laser is demonstrated. The air-broadening of three oxygen A-band lines is determined, using a least-squares fit. For a peak absorption of 1.3 x 10(-3) the deviation between the experimental and the fitted spectrum is less than 1%. The fitting procedure is succ
A major complication of multiple myeloma (MM) is the development of osteolytic lesions, fractures and bone pain. To identify genetic variants influencing the development of MM bone disease (MBD), we analyzed MM patients of European ancestry (totalling 3774) which had been radiologically surveyed for MBD. Each patient had been genotyped for ~600 000 SNPs with genotypes for six million common varian
På en lekplats eller i en nöjespark finns möjlighet att påtagligt uppleva begrepp från fysik och matematik med den egna kroppen. Med hjälp av tidsmätningar kan man få förståelse för gungans pendelrörelse och även en matematisk modell. Innehållet presenterades på matematikbiennalen i Umeå.
BACKGROUND: Balance impairment is one of the most distressing symptoms in Parkinson's disease (PD) even with pharmacological treatment (levodopa). A complementary treatment is high frequency stimulation in the subthalamic nucleus (STN). Whether STN stimulation improves postural control is under debate. The aim of this study was to explore the effects of STN stimulation alone on balance performance
