Background: Childhood cancer survivors are at risk of subsequent primary soft-tissue sarcomas (STS), but the risks of specific STS histological subtypes are unknown. We quantified the risk of STS histological subtypes after specific types of childhood cancer.Methods: We pooled data from 13 European cohorts, yielding a cohort of 69 460 five-year survivors of childhood cancer. Standardized incidence

The Paris Agreement seemingly reaffirmed the central place occupied by the regime established by the UNFCCC in the international governance of climate change.Although the UNFCCC can be viewed as a form of ‘monocentric’ governance, it has become increasingly clear that the UNFCCC operates as part of a polycentric governance system. Due to the physical and socio-economic interconnections between cli

The Theory of Characteristic Modes (TCM) offers a natural and systematic way to design Multiple-Input Multiple-Output (MIMO) antennas with high total efficiency and uncorrelated antenna patterns. In this paper, recent advances in the growing field of TCM-aided MIMO antenna design are reviewed. In particular, the focus is on the challenging problem of designing MIMO antennas for compact mobile term

Polycentricity is characterised by institutional fragmentation as well as a new quality of interdependence where non-state and state actors are both regulators and regulated. This complexity raises new questions for democratic governance beyond the nation state. Against this backdrop, we first develop the argument that certain legitimacy and accountability challenges are inherent to polycentricity

The purpose of this studywas to investigate the prognostic value of lactate at admission, 12-h lactate and 12-h lactate clearance for 30-day survival in comatose patients admitted after out of hospi tal cardiac Arrest (OHCA). Although measures of lactate have been successfully implemented in sepsis and trauma care, most OHCA studies are biased due to design and the results are conflicting. This is

Health plays an essential role for human and economic development. This thesis consists of four independent empirical papers on health and health care in developing countries. The first paper investigates the relationship between globalization, democracy, and child health in low- and middle-income countries. Using panel data for 70 developing countries between 1970 and 2009 we examine how globaliz

Introduction: Serum lactate is considered to be a marker of tissue hypoxia (1) Cut-off values >4 mM predict poor outcome, yet many patients after resuscitation according Surviving Sepsis Campaign guidelines (SSCG) (2) have high mortality despite decreases in blood lactate. Our hypothesis was that dynamic, rather than absolute blood lactate concentrations predict survival. Further we tested the abi

If we do not consider religious rituals as given to us from the gods, but designed by humans at certain times and in certain contexts we might also track the art of designing and performing the human practice of rituals. Even if we agree that all rituals are taught and learned, they are not meant to be perceived as products of human imagination. The concept “ritual invention” could thus be seen as

This doctoral dissertation investigates how Plato elaborates and incorporates the works of the poets in the preludes to the laws. It is argued that the poetic style of the preludes represents a key element for the Athenian’s purpose of persuading the citizens of Magnesia to spontaneously abide to the new legislation that is being laid out.The analysis is divided in four chapters. Chapter 1 discuss

Gastroesophageal reflux disease (GERD) has a prevalence of 20% based on weekly symptoms of heartburn and regurgitation. As reflux symptoms are unspecific for GERD, an objective evaluation of the presence of the disease is often needed. Ambulatory pH monitoring is the most commonly used diagnostic method but it is limited by relatively poor sensitivity, especially in patients without esophagitis. T

Introduction: The fact that the majority of older people wish to remain and live independently in their current homes calls for a more comprehensive understanding of which aspects of the home support healthy ageing. Perceived aspects of home influence life satisfaction, perceived health, independence in daily activities and well-being among people aged 80 years and older. However, health and perce

We use Baker, Bloom, and Davis’s (2016) economic policy uncertainty indices in combination with the mixed data sampling (MIDAS) approach to investigate long-run stock market volatility and correlation, primarily for the US and UK. Long-run US–UK stock market correlation depends positively on US economic policy uncertainty shocks. The dependence is asymmetric, with only positive shocks - increasing

Colorectal cancer (CRC) is one of the most common forms of cancer. The cause of CRC is multifactorial, and lifestyle factors are thought to be a major contributor to the development of CRC. It can be hypothesised that the association between food intake and the risk of developing CRC depends not only on the food consumed, but what it is consumed in combination with. The associations between food a

By measuring scattering parameters over a wide range of bias points, we study the intrinsic gate capacitance as well as the charge partitioning of vertical nanowire tunnel field-effect transistors (TFETs). The gate-to-drain capacitance Cgd is found to largely dominate the on-state of TFETs, whereas the gate-to-source capacitance Cgs is sufficiently small to be completely dominated by parasitic com