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microRNAs (miRNAs) are widespread regulators of gene expression, but little is known of their potential roles in congenital muscular dystrophy type 1A (MDC1A). MDC1A is a severe form of muscular dystrophy caused by mutations in the gene encoding laminin α2 chain. To gain insight into the pathophysiological roles of miRNAs associated with MDC1A pathology, laminin α2 chain-deficient mice were evalua

Charged particle production in deep-inelastic ep scattering is measured with the H1 detector at HERA. The kinematic range of the analysis covers low photon virtualities, 5 < Q(2) < 100 GeV2, and small values of Bjorken-x, 10(-4) < x < 10(-2). The analysis is performed in the hadronic centre-of-mass system. The charged particle densities are measured as a function of pseudorapidity (n(*)) and trans

The dissertation is about career in working life – not career solely in the sense of climbing upwards in the organizational hierarchy to management level, but career as the movement that individuals or groups make over time through working life. The focus is on social workers and their professional field. The overall aim is to describe and analyse social workers’ career patterns and careers at the

Sixty-four Polish families with a history of breast and/or ovarian cancer were screened for mutations in the BRCA1/2 genes using a combination of denaturing high performance liquid chromatography (DHPLC) and sequencing. Two thirds (43/64; 67%) of the families were found to carry deleterious mutations, of which the most frequent were BRCA1 5382insC (n=22/43; 51%) and Cys61Gly (n=9/43; 20%). Two oth

2012 är året då tsunamin drabbade högre utbildning. Den öppna utbildningskulturen slår igenom på bred front i hela världen, bland annat genom att prestigeuniversitet, inte minst i USA, erbjuder kurser gratis online och globalt till alla. Men i Sverige är öppen utbildning ännu i hög grad en icke-fråga, speciellt bland myndigheter och utbildningsorganisationer.

The article examines the influence of linguistic distance on the labor market outcomes of a sample of 5,041 first generation immigrants in Sweden between 1970 and 1990. The article exploits register data from the Swedish Longitudinal Database, examining a population of individuals from 11 non-Nordic countries of origin. The analysis focuses on the transition to the Swedish labor market, comparing

Treatment in medical oncology is gradually shifting from the use of nonspecific chemotherapeutic agents toward an era of novel targeted therapy in which drugs and their combinations target specific aspects of the biology of tumor cells. Multiple myeloma (MM) has become one of the best examples in this regard, reflected in the identification of new pathogenic mechanisms, together with the developme

Popular Abstract in Uncoded languages A modern tartószerkezeti szabványok általában két fő követelményt támasztanak a tartószerkezetekekkel, illetve szerkezeti elemekkel szemben. Az egyik a tönkremenetellel szembeni biztonsághoz, míg a másik a használhatósághoz kapcsolódik. A szerkezeti használhatóság a tartószerkezet azon képessége, hogy tervezett szerepét élettartams során folyamatosan betöltse.In many design situations the acceptable performance of structures is defined by serviceability requirements. To estimate the probability of serviceability failure three main design aspects should be considered: (1) the relevant exposures, (2) the structural response and (3) the performance criteria. This thesis presents background information and new findings on structural serviceability related

In this work, the nucleation and growth of InAs nanowires on patterned SiO2/Si(111) substrates is studied. It is found that the nanowire yield is strongly dependent on the size of the etched holes in the SiO2, where openings smaller than 180 nm lead to a substantial decrease in nucleation yield, while openings larger than View the MathML source promote nucleation of crystallites rather than nanowi

The last several decades have seen an increase in male infertility concomitant with a decline in the birth sex ratio. The conditions are believed to be linked to increased exposure to endocrine disrupting chemicals (EDCs), including the persistent organic pollutants or lifestyle factors e.g. smoking. The mechanism behind the lowered birth sex ratio is unknown, but might be due to an EDC-induced sk

It has been proposed that vascular progenitor cells play an important role in vascular repair, but their possible clinical importance in cardiovascular disease has not been fully characterized. Vascular endothelial growth factor A, placental growth factor and stem cell factor (SCF) are three growth factors that are important in recruiting vascular progenitor cells. In this study, we investigated t

Ground-source heat pump systems use borehole heat exchangers to transfer heat to and from the ground. An important feature is the local thermal resistances between the heat carrier flow channels in the borehole and the surrounding ground. The counter-flow heat exchange between the pipes is also important, particularly for the axial temperature variation. These resistances can be represented by a t

Events with high energy isolated electrons, muons or tau leptons and missing transverse momentum are studied using the full e(+/-)p data sample collected by the H1 experiment at HERA, corresponding to an integrated luminosity of 474 pb(-1). Within the Standard Model, events with isolated leptons and missing transverse momentum mainly originate from the production of single W bosons. The total sing

While each new generation of processors gets larger caches and more compute power, external memory bandwidth capabilities increase at a much lower pace. Additionally, processors are equipped with wide vector units that require low instruction level divergence to be efficiently utilized. In order to exploit these trends in ray tracing, we present an alternative to traditional depth-first ray traver

It is recognized that cooling methods incorporating micro-channel heat sinks with high capacities of heat removal are necessary for cooling of electronic devices. In this paper, based on a water-cooled smooth micro-channel heat sink, a series of rectangular-shaped flow obstructions are designed into a heat sink, and then the corresponding laminar flow and heat transfer have been analyzed numerical

In November 2011, the Third European Consensus Conference on Diagnosis and Treatment of Germ-Cell Cancer (GCC) was held in Berlin, Germany. This third conference followed similar meetings in 2003 (Essen, Germany) and 2006 (Amsterdam, The Netherlands) [Schmoll H-J, Souchon R, Krege S et al. European consensus on diagnosis and treatment of germ-cell cancer: a report of the European Germ-Cell Cancer