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This is an overview paper that motivates and describes performed work done in the European Commission funded research project BASTION, which focuses on two critical problems of modern electronics: the No-Fault-Found (NFF) and CMOS ageing. New defect classes contributing to NFF have been identified, including timing related faults (TRF) at board level and intermittent resistive faults (IRF) at IC l
Scholars and policy makers consider knowledge accumulation a major driver of growth and regional development. During the past two decades, the geography of innovation literature has provided a rich and detailed account of the underlying processes of regional knowledge production. More recently, a growing body of empirical literature has analysed the specific knowledge bases of regions and their ev
The retina is a thin tissue layer on the inside of the eye and may be subject to tractional forces in diseases like myopia, retinoschisis, and retinal detachment. Müller glial cells (MGCs) are the only cells spanning the entire retinal thickness and hypothetically respond to mechanical stress imposed across retinal layers. We designed a device to apply force in vitro perpendicular to the retinal sThe retina is a thin tissue layer on the inside of the eye and may be subject to tractional forces in diseases like myopia, retinoschisis, and retinal detachment. Müller glial cells (MGCs) are the only cells spanning the entire retinal thickness and hypothetically respond to mechanical stress imposed across retinal layers. We designed a device to apply force in vitro perpendicular to the retinal s
Identification of metabolites in non-targeted metabolomics continues to be a bottleneck in metabolomics studies in large human cohorts. Unidentified metabolites frequently emerge in the results of association studies linking metabolite levels to, for example, clinical phenotypes. For further analyses these unknown metabolites must be identified. Current approaches utilize chemical information, suc
Introduction In the context of public transportation, just as in many parts of society, the level of organizational complexity has increased over the last twenty years. Due to structural reforms and policy adjustments, responsibilities for the public transportation system in Sweden have become increasingly divided between a variety of public and private actors, thus fragmenting the organizational
Muller cells are the principle glia cells of the retina that maintain the integrity and function of the retina and are thought to support and protect neurons during various insults. α2-adrenergic receptor agonists have been shown to be neuroprotective and Mu[[unable to display character: ̈]]ller cells are suggested to take part in these effects. The purpose of this project was to study thMuller cells are the principle glia cells of the retina that maintain the integrity and function of the retina and are thought to support and protect neurons during various insults. α2-adrenergic receptor agonists have been shown to be neuroprotective and Mu[[unable to display character: ̈]]ller cells are suggested to take part in these effects. The purpose of this project was to study th
The aim of the current study was to compare lower urinary tract symptoms (LUTS), erectile dysfunction (ED), and quality of life (QoL) in poststroke and healthy men. Thirty poststroke men with stroke-related LUTS, and as controls, 96 healthy men participated in this controlled, cross-sectional study. Participants filled in the Danish Prostate Symptom Score (DAN-PSS-1) Questionnaire, the Internation
Spasticity is a locomotory disability that is common after injury to the spinal cord. Monoamines such as serotonin and dopamine controls the activation of motoneurons, which in turn affects muscle. Aromatic L-amino acid decarboxylase (AADC) catalyzes formation of serotonin from 5-hydroxytryptophan and dopamine from L-dihydroxyphenylalanine. To study if there are cells in the primate spinal cord th
Agricultural intensification is a leading cause of global biodiversity loss, which can reduce the provisioning of ecosystem services in managed ecosystems. Organic farming and plant diversification are farm management schemes that may mitigate potential ecological harm by increasing species richness and boosting related ecosystem services to agroecosystems. What remains unclear is the extent to wh
Chromites from Middle Ordovician fossil L chondrites and from matrix and shock-melt veins in Catherwood, Tenham, and Coorara L chondrites were studied using Raman spectroscopy and TEM. Raman spectra of chromites from fossil L chondrites showed similarities with chromites from matrix and shock-melt veins in the studied L chondrite falls and finds. Chromites from shock-melt veins of L chondrites sho
Posttraumatic stress disorder (PTSD) is associated with increased risk for Type 2 diabetes and cardiovascular disease (cardiometabolic disease), warranting research into targeted prevention strategies. In the present case–control study of 160 young (mean age 32.7 years) male military veterans, we aimed to assess whether PTSD status predicted increased markers of cardiometabolic risk in otherwise h
BACKGROUND. Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual variability in cardiac structure and function. METHODS. A GWAS meta-analysis of echocardiographic traits was performed, including 46,533 individuals from 30 studies (EchoGen
This report deals with the identification of ATP/ADP translocase genes. In rickettsial species such as Rickettsia prowazekii, which is the cause of epidemic typhus in humans, the utilisation of host cell ATP is the major way that this bacterium employ its toxicity in the host cell. This obligate intracellular bacterium is an energy-parasite. In the genome of R. prowazekii there are five homologs o
I det här arbetet har de neurotoxiska effekterna av paraquat och roundup studerats, efter en neonatal lågdos-exponering. Paraquat förekommer i miljön och dess likhet med det neurotoxiska ämnet l-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) gör den intressant i neurotoxikologiskt avseende. Detta arbete omfattar tre olika försök. I försök 1) exponerades möss neonatalt for paraquat, dessa djur av
We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive pe
