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Sensitive detection of short nucleic acids is used to identify viral and bacterial diseases, detect biomarkers of cancer, as well as in gene expression studies. Currently available techniques such as PCR, electrochemical detection and SPR are typically costly and often require amplification of the DNA. Here, we demonstrate a sensing system for picomolar detection of short single-stranded DNA by fl
Background The aim of this systematic review and meta-analysis was to examine autoantibody positive individuals and define: (a) the relative risk of rheumatoid arthritis (RA) compared with autoantibody negative individuals and (b) the cumulative incidence of RA over time, in different populations. Methods A systematic literature search was performed in August 2025. Retrospective case control studi
Astrometric observations can, in principle, be used to detect gravitational waves. In this paper, we give a practical overview of the gravitational wave effects which can be expected specifically in small-field astrometric data. Particular emphasis is placed on the differential effect between pairs of sources within a finite field of view. We also present several general findings that are not rest
Animals align their body in relation to different environmental cues, including spontaneous directional responses relative to the geomagnetic field known as magnetic body alignment. The biological significance of this behavior, however, remains undetermined for most taxa. In previous studies, migratory songbirds aligned their body with the cardinal directions of the geomagnetic field and their mig
Scholars have characterized Cambodia as a weak state, strong party governance system in which administrative institutions are subordinated to the ruling Cambodian People’s Party (CPP). This article argues that since 2013 Cambodian governance has taken a significant technocratic turn, as party rule has become increasingly dependent on a stronger and more capable administrative state. It traces a re
District heating networks are an integral part of the energy system in many countries. In future smart energy systems, they are expected to enhance energy flexibility and support the integration of renewable and waste energy sources. An important aspect of these networks is the control of flow rates, which dictates the heat delivered to consumers. This paper concerns the properties of flow rates i
We explore mental health as a potential mechanism to explain the labor market penalty of an early-onset physical disability using administrative data from Sweden. For methodological reasons, we focus on persons with Cerebral Palsy (CP) and use prescriptions for mental health conditions. We examine how much of the differences in labor market outcomes is explained by prescriptions for mental health
Despite recommendations to use oral lipid-lowering therapies (LLT) in secondary prevention of atherosclerotic cardiovascular disease, numerous studies have shown substantial under-utilization. We assessed long-term persistence and dynamics of adherence to oral LLTs in patients after their first ever myocardial infarction (MI) in Sweden. A total of 83,407 patients with a MI (2010–2017) and who were
Non-ordinary states of consciousness (NOC) offer a way to examine how large-scale brain dynamics reorganize as experience changes. We studied a participant able to reliably enter a self-induced NOC state characterized by vivid imagery, altered bodily perception, and a sense of unity. Across 20 fMRI sessions, we measured functional connectivity in four conditions (Baseline, Transition, NOC, and Res
Many different types of insects make seasonal migrations over vast distances, typically from one broad geographical region to another, most often involving a latitudinal change in one direction in spring with a reversal of this direction in autumn. However, a small handful of these species instead migrate from an enormous geographical area to a highly specific destination they have never previousl
The speed at which the number of battery electric vehicles is growing is fueling debates and research on the criticality of battery materials. But rapid growth also enables fast uptake of new cathode chemistries, and electric vehicle batteries show considerable flexibility and material substitutability. Historical scaling of production is more dynamic than recognized in scenarios of future mineral
Heterochromatin is characterized by an inaccessibility to the transcriptional machinery and is associated with the histone mark H3K9me3. However, studying the functional consequences of heterochromatin loss in human cells has been challenging. Here, we used CRISPRi-mediated silencing of the histone methyltransferase SETDB1 to remove H3K9me3 heterochromatin in human neural progenitor cells. Despite
BACKGROUND: Early-career researchers (ECRs) play a vital role in scientific progress; however, academic environments and personal characteristics may influence their mental health and capacity to work. This study explored factors associated with mental health among ECRs in dementia research (ECDRs).METHODS: We analyzed data from an international cross-sectional survey of 283 ECDRs using a logistic
Premise: Flower color, a key trait influencing plant–pollinator interactions, may be influenced by abiotic factors such as soil. We investigated association between pollinators, soil characteristics, and flower color variations in Digitalis purpurea across native populations in Sweden and introduced populations in Bolivia. Methods: We measured floral traits, reflectance of petals and nectar-guide
Background: Reuse of sterile textiles could potentially reduce the carbon footprint of operating theatres. The aim of this mixed-methods study is to gain a deeper understanding of the implementation of reusable drapes and gowns across different contexts through applying the Consolidated Framework for Implementation Research (CFIR).Methods: A mixed-methods analysis was performed of cross-sectional
10Be deposition in ice cores is widely used for solar reconstructions, but its interpretation is complicated by volcanic influences. Using the state-of-the-art aerosol-climate model ECHAM6.3-HAM2.3-SALSA2.0: 10Be, we assess the impacts of three major volcanic eruptions: Agung (1963), El Chichón (1982) and Pinatubo (1991). All eruptions enhance stratospheric 10Be sedimentation, increasing atmospher
Thermal performance curves (TPCs) capture how population growth depends on temperature. When temperatures increase, such as during global change, TPCs may evolve to match new environmental temperatures. While previous studies mostly focus on population growth rate TPCs, evolution can also be strongly trait-dependent and require a multi-trait analysis. Here, we empirically tested how TPCs and multi
Transpiration drives up to 40 % of terrestrial precipitation, with forests playing a critical role. This study combines long-term sap flow measurements and surface-based cloud observations to examine how different clouds affect tree transpiration across boreal and temperate European forests. Under specific cloudy conditions, sap flow can exceed clear-sky levels, reflecting distinct radiation effec
Objective: Interstitial lung disease (ILD) can occur in association with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV-ILD) or as an isolated entity with positive ANCA (ANCA-ILD). However, data on the epidemiology and outcomes of these conditions remain limited. Methods: A European multicenter retrospective study encompassed patients with AAV-ILD or ANCA-ILD. Baseline and s
