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Vaccine candidates are typically identified through characterization of microbial surface antigens expressed under laboratory conditions. Here, we studied the major human pathogen Streptococcus pyogenes and showed that Slr, a lipoprotein encoded by all strains, is not detected on the bacterial surface during growth in broth but nevertheless is targeted by protective antibodies in vivo, as demonstr
International law provides for the autonomy of the Åland Islands. The source of this law (“the Åland Islands Autonomy Regime”) is far from clear and much debated. A literature survey furnishes five possibilities. Thus, the Regime may have been created: (i) by the conclusion of a bilateral agreement; (ii) by unilateral declaration; (iii) by the conclusion of a bilateral agreement and the tacit acce
Objective: To describe the epidemiology, organ involvement, histopathological patterns, and clinical management of immunoglobulin G4-related disease (IgG4-RD) in Stockholm County, Sweden. Method: Patients with an International Classification of Diseases, 10th revision, Swedish Edition (ICD-10-SE) diagnosis of IgG4-RD recorded between 2019 and 2023 were identified from the Swedish National Patient
Purpose: To comparatively map primary health care (PHC) nurses’ roles across European countries (including Austria, Denmark, Estonia, Norway, Portugal, Slovenia, Sweden) identify convergences and divergences in scope of practice, education, roles, and regulation, and explore advanced practice and care navigation functions. The workshop engages participants to discuss experiential, organizational,
Early Music makes fundamental contributions to society and cultural identity, from mass media to tourist sites, from annual festivals to national heritage projects. Yet Early Music research often has difficulty conforming to institutional and policy-based categories and definitions at a European level, typically being divided between two major policy domains: science & research, represented by
Reliable building performance management involves reducing energy use and peak demand while maintaining indoor comfort and operational safety. Achieving these objectives requires effective strategies across the building life cycle, from early-stage design to operation. However, the availability, quality, and structure of building data vary considerably between life cycle stages. Buildings in opera
This study introduces a reinforcement-learning-based sequential sampling framework for adaptive control charts. Traditional adaptive charts improve monitoring efficiency by adjusting sampling effort according to the current chart state, but they require manually specified decision regions and region-to-action assignments. This becomes difficult when many sample-size and sampling-interval combinati
We develop a continuous-time framework in which the risk associated with leverage is parameterized by a dimensionless drawdown-risk index relative to an arbitrary reference asset. We further show that the growth-optimal Kelly portfolio is the unique portfolio whose relative drawdown-risk index is invariant to the reference asset. Additionally, we characterize when portfolios have equal relative dr
European forests have historically served as a major carbon sink and are a crucial part of the LULUCF sector for net-zero planning in many countries. However, national greenhouse gas inventories report that forest sink capacity has declined by one-third over the past decade. This decline has been attributed to be due to multiple interacting factors: climate conditions that now constrain rather th
Ovarian cancer remains a major clinical challenge due to its pronounced heterogeneity and the high incidence of chemoresistance and metastatic dissemination. Despite advances in molecular profiling, the functional mechanisms driving these processes remain incompletely understood, limiting the development of effective targeted therapies. Addressing this gap requires approaches that capture the dyna
ULF – Utbildning, Lärande och Forskning – är ett nationellt initiativ som syftar till att stärka skolans vetenskapliga grund genom långsiktig samverkan mellan lärosäten och skolhuvudmän. Målet är att utveckla hållbara strukturer för praktiknära forskning som utgår från skolans behov och samtidigt stärker lärarutbildningens forskningsanknytning och professionens kunskapsutveckling.Under försöksperi
Electrophysiological approaches are widely used to characterize insecticide target sites, whereas behavioral symptoms associated with different modes of action remain less quantitatively explored. Here, we developed a computer vision–based framework to quantify insecticide-induced behavioral responses in the cotton aphid, Aphis gossypii Glover (Hemiptera: Aphididae). Convolutional neural networks
This study investigates how physical alterations of paths, including changes in surfacing and lighting conditions, impact the behaviour of pedestrians and cyclists. Using drone-based imaging technologies, data were collected from shared-use paths in two Swedish cities during periods of reduced daylight hours. The study focused on speed and slalom, examining how these measures varied across differe
Purpose: To longitudinally assess fatigue, physical and daily activity, and work ability 7 years post therapy in a radiotherapy-treated cohort, and to compare the long-term data with matched non-cancer referents from the general population. Methods: A questionnaire assessed fatigue, concurrent symptoms, and physical and daily activity including work ability during radiotherapy and at a 7-year foll
