This study aims to investigate the cooling performance of various film cooling holes, including combined hole, cylinder hole, conical hole, and fan-shaped hole. For film cooling technology, a novel combined hole configuration is first proposed to improve the cooling protection for gas turbine engines. This combined hole consists of a central cylinder hole (an inclination angle of 35°) and two addi

Positioning is an essential feature in Narrow-Band Internet-of-Things (NB-IoT) systems. Observed Time Difference of Arrival is one of the supported positioning techniques for NB-IoT. It utilizes the downlink NB positioning reference signal (NPRS) generated based on a length-31 Gold sequence. Although a Gold sequence has good auto-correlation and cross-correlation properties, the correlation proper

We consider time-of-arrival (ToA) estimation for a device working in narrowband Internet-of-Things (NB-IoT) systems. Due to a limited 180 kHz bandwidth, the time-domain auto-correlation function (ACF) of transmitted NB positioning reference signal (NPRS) has a wide main-lobe. Without considering that, the performance of ToA estimation can be degraded for two reasons. Firstly, the NPRS correspondin

We propose an improvement over a modulus zero-forcing (MZF) detector proposed earlier in [1] for multi-input multi-output (MIMO) detection, namely, the joint MZF (JMZF) detector. The MZF detector provides better detection-performance than a traditional ZF detector through preserving controllable interferences, which are mitigated later by nonlinear modulus arithmetic operation. However, the MZF de

We consider Boolean circuits over {∨, ∧, ¬} with negations applied only to input variables. To measure the “amount of negation” in such circuits, we introduce the concept of their “negation width.” In particular, a circuit computing a monotone Boolean function f(x1, . . ., xn) has negation width w if no nonzero term produced (purely syntactically) by the circuit contains more than w distinct negat

Aims: Few studies have examined how improved metabolic control might influence vibration perception thresholds (VPTs). The aim of this study was to evaluate if improved HbA1c can influence vibration thresholds in adults with type 1 diabetes (T1DM). Methods: VPTs were investigated at six frequencies (4–125 Hz) using VibroSense Meter in the sole of the foot at two occasions in 159 T1DM patients, at

Previous open-label trials testing glial cell line-derived neurotrophic factor (GDNF) family ligands in Parkinson disease have shown promising clinical effects. However, in placebo-controlled trials, the treatments have failed. A new randomized placebo-controlled trial of intraputamenal delivery of GDNF designed to resolve this conundrum has again failed to do just that.

Accumulating data suggest that neutrophil extracellular traps (NETs) exert a key function in several diseases. Peptidylarginine deiminase 4 (PAD4) regulates NET formation via citrullination of histones. The aim of this study was to examine the role of miR-155 in controlling PAD4-dependent generation of NETs. Bone marrow neutrophils were stimulated with PMA and MIP-2. Pre-incubation of neutrophils

Genomgång av existerande dokumentation i Lunds universitetsarkiv rörande folkbildaren och riksdagsmannen Oscar Olssons studietid 1897-1902 med särskilt fokus på Hans Larssons undervisning under denna period.

Shotgun proteomics based on peptide fractionation by using liquid chromatography has become the common procedure for proteomic studies, although in the very beginning of the field, protein separation by using electrophoresis was the main tool. Nonetheless, during the last two decades, the electrophoretic techniques for peptide mixtures fractionation have evolved as a result of relevant technologic

Biografisk artikel om Bengt Bergius (1723-1784) med fokus på dennes "Tal om läckerheter" inför Kungl. Vetenskapsakademien 1780.

This chapter discusses the changes in protein phosphorylation following ischemia, with particular reference to the regulation of the initiation of protein synthesis. Transient cerebral ischemia seems to induce a post-ischemic imbalance between protein kinase and protein phosphatase activities, leading to a net dephosphorylation of proteins in the vulnerable neurons. This imbalance may lead to the

This chapter is a first attempt to capture the phenomenon of inter-firm credit between breweries and bars and restaurants in Sweden. I ask three interrelated questions: 1. Why do breweries in Sweden provide credit to bars and restaurants? 2. How is this credit designed? 3. What are the effects of this credit relationship? Question 2 is about the design of this credit and focuses on the aspects of

INTRODUCTION: Drugs directed toward the epidermal growth factor receptor (EGFR), such as erlotinib (Tarceva®) and gefitinib (Iressa®), are used for the treatment of patients with advanced non-small cell lung cancer (NSCLC), including patients with brain metastases. However, whether erlotinib actually enters into brain metastases has not been adequately elucidated. In this study, we investigated th

Situations of multilingualism and language contact in which language varieties are small in scale and relatively equal in social status are important phenomena affecting processes of language change throughout human history. Despite this, our knowledge about the outcomes of multilingualism and language contact in this kind of setting remains limited. The current thesis provides insight into the li