BackgroundPatients with Huntington's disease display symptoms from both the central nervous system and peripheral tissues. Mitochondrial dysfunction has been implicated as part of the pathogenesis of the disease and has been reported in brain tissue and extracerebral tissues, such as muscle and blood cells, but the results are inconsistent. Therefore, the authors performed a refined evaluation of

In this paper we report some results of our numerical simulations of sprays in compressible flows using Large Eddy Simulation. The combined LES- and spray code has been applied to the computation of the flow and spray injection into a swirl generator of a gas-turbine. The interaction between the spray jet and the flow field has been investigated. A dynamic SGS model has been used and results have

Versioning of components in a system is a well-researched field where various adequate techniques have already been established. In this paper, we look at how versioning can be extended to cover also the structural aspects of a system. There exist two basic techniques for versioning - intentional and extensional - and we propose a unified extensional versioning model for versioning of both compone

A high order Cartesian grid method is developed and applied to large eddy simulations (LES) of isothermal and reactive turbulent flows. Cartesian grid methods are potentially the most suitable numerical methods for LES because of its economical storage requirement, less computational effort per computational cell, fast numerical convergence and feasibility for constructing higher order finite diff

This paper presents a technique for product configuration modelling based on object-orientation and attribute grammars. The technique allows efficient interactive configurator tools to be generated for specified product families. Additional benefits include a high degree of checkability, early validation, readability, and reusability. The technique is particularly aimed at mass-customization produ

The purpose in this paper is to show how public procurement can be a driver ofinnovation. The purpose and point of departure when using public procurement as an instrument of innovation policy is always to solve societal and environmental problems, to satisfy human needs or to meet global challenges. The paper is aimed at everyone who is involved or interested in public procurement, and especially

According to the Innovation Union Scoreboard published by the EuropeanCommission, Sweden has been, and still is, an innovation leader within the EU and one of the most innovative countries in Europe. In this paper, the performance of the Swedish national innovation system is analyzed using exactly the same data as those employed by the Innovation Union Scoreboard for the years 2014 and 2015.We arg

According to the Innovation Union Scoreboard, published by the European Commission every year, Sweden has been, and still is, an innovation leader within the EU and one of the most innovative countries in Europe. In the Innovation Union Scoreboard 2014 (European Union, 2014: 5), Sweden has the top position (ranked number 1) of all EU28 Member States in what is called “EU Member States’ Innovation

The persistence length of cationic dendronized polymers adsorbed onto oppositely charged substrates was studied by atomic force microscopy (AFM) and quantitative image analysis. One can find that a decrease in the ionic strength leads to an increase of the persistence length, but the nature of the substrate and of the generation of the side dendrons influence the persistence length substantially.

In this paper, we provide a formalism for the characterization of tracking arrays with emphasis on the proper corrections required to extract their photopeak efficiencies and peak-to-total ratios. The methods are first applied to Gammasphere, a well characterized 4π array based on the principle of Compton suppression, and subsequently to GRETINA. The tracking efficiencies are then discussed and so

This work presents a digital calibration technique in continuous-time (CT) delta-sigma (Δ Σ) analog to digital converter. The converter is clocked at 144 MHz with a low oversampling ratio (OSR) of only 8. Dynamic element matching is not efficient to linearize the digital to analog converter (DAC) when the OSR is very low. Therefore, non-idealities in the outermost multi-bit feedback DAC are measur

Epigenetic variation in human adipose tissue has been linked to type 2 diabetes and its related risk factors including age and obesity. Insulin resistance, a key risk factor for type 2 diabetes, may also be associated with altered DNA methylation in visceral and subcutaneous adipose tissue. Furthermore, linking epigenetic variation in target tissues to similar changes in blood cells may identify n