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Impact of musculoskeletal symptoms on general physical activity during nursing education.

Nursing education should prepare students for a lifelong professional career including managing clinical physical demands. Musculoskeletal symptoms, such as bodily pain, have been reported among nurses and nursing students but less is known about the impact of symptoms in daily activities. The aim was to explore the prevalence of self-reported musculoskeletal symptoms and their impact on general p

Habitat-specific bird trends and their effect on the Farmland Bird Index

Farmland birds in Europe have declined in numbers from the last decades, as reflected in the Farmland Bird Index (FBI), a multi-species indicator of population trends adopted by the European Union. Some of these farmland bird species breed to a varying degree also in non-farmland habitats: however, the indicator is calculated using trends estimated from all birds counted of each species, irrespect

Joint protection in haemophilia

Haemarthroses (intra-articular haemorrhages) are a frequent finding typically observed in patients with haemophilia. Diagnosis and treatment of these bleeding episodes must be delivered as early as possible. Additionally, treatment should ideally be administered intensively (enhanced on-demand treatment) until the resolution of symptoms. Joint aspiration plays an important role in acute and profus

Cryogelation of Chitosan Using Noble-Metal Ions: In Situ Formation of Nanoparticles.

One of the purposes of the project was to develop the method of preparation of 3D macroporous hydrogel with a structure of interconnected pores by the use of noncovalent interactions. The combination of chitosan and noble-metal complexes was investigated as cross-linking agents for the preparation of ionic cryogels (ICs). Furthermore, the treatment of the ICs containing gold complex by glutaraldeh

Intraneuronal A beta Accumulation, Amyloid Plaques, and Synapse Pathology in Alzheimer's Disease

Background: beta-Amyloid (A beta) plaques are a pathological hallmark of Alzheimer's disease (AD) and multiple lines of evidence have linked A beta with AD. However, synapse loss is known as the best pathological correlate of cognitive impairment in AD, and intraneuronal A beta accumulation has been shown to precede plaque pathology. The progression of A beta accumulation to synapse loss and plaqu

The use of biomarkers for the etiologic diagnosis of MCI in Europe: An EADC survey.

We investigated the use of Alzheimer's disease (AD) biomarkers in European Alzheimer's Disease Consortium centers and assessed their perceived usefulness for the etiologic diagnosis of mild cognitive impairment (MCI). We surveyed availability, frequency of use, and confidence in diagnostic usefulness of markers of brain amyloidosis (amyloid positron emission tomography [PET], cerebrospinal fluid [

What’s in an EEM? : molecular signatures associated with dissolved organic fluorescence in boreal Canada

Dissolved organic matter (DOM) is a master variable in aquatic systems. Modern fluorescence techniques couple measurements of excitation emission matrix (EEM) spectra and parallel factor analysis (PARAFAC) to determine fluorescent DOM (FDOM) components and DOM quality. However, the molecular signatures associated with PARAFAC components are poorly defined. In the current study we characterized riv

Modeling plant growth and pattern formation.

Plants continue to grow and generate new organs in symmetric patterns throughout their lives. This development requires an interconnected regulation of genes, hormones, and anisotropic growth, which in part is guided by environmental cues. Recently, several studies have used a combination of experiments and mathematical modeling to elucidate the mechanisms behind different growth and molecular pat

Fast Fourier Methods for Synthetic Aperture Radar Imaging

In synthetic aperture radar one wishes to reconstruct the reflectivity function of a region on the ground from a set of radar measurements taken at several angles. The ground reflectivity is found by interpolating measured samples, which typically lie on a polar grid in frequency space, to an equally spaced rectangular grid in frequency space, then computing an inverse Fourier transform. The class

Climate variability and glacial processes in eastern Iceland during the past 700 years based on varved lake sediments

Properties of varved sediments from Lake Logurinn in eastern Iceland and their link to climate and glacial processes of Eyjabakkajokull, an outlet glacier of the Vatnajokull icecap, were examined. A varve chronology, which covers the period AD 1262-2005, was constructed from visual observations, high-resolution images, X-ray density and geochemical properties determined from X-radiography and X-ra

On the Shift Semigroup on the Hardy Space of Dirichlet Series

We develop a Wold decomposition for the shift semigroup on the Hardy space H-2 of square summable Dirichlet series convergent in the half-plane R(s) > 1/2. As an application we have that a shift invariant subspace of H-2 is unitarily equivalent to H-2 if and only if it has the form phi H-2 for some H-2-inner function phi.

Computational modeling of the mechanism of urease.

In order to elucidate aspects of the mechanism of the hydrolytic enzyme urease, theoretical calculations were undertaken on a model of the active site, using density functional theory. The bridging oxygen donor that has been found in the crystal structures was determined to be a hydroxide ion. The initial coordination of urea at the active site occurs most likely through the urea oxygen to the nic

Two consecutive randomized controlled pertussis booster trials in children initially vaccinated in infancy with an acellular vaccine: The first with a five-component Tdap vaccine to 5-year olds and the second with five- or monocomponent Tdap vaccines at age 14-15 years.

Prior study children from a DTaP efficacy trial were recruited at ages 5 and 15 years to randomized booster trials addressing immunogenicity and reactogenicity; 475 preschool children received mixed or separate injections of a reduced antigen vaccine (Tdap5, Sanofi Pasteur MSD) and an inactivated polio vaccine, and 230 adolescents received the same or another booster vaccine (Tdap1, SSI, Denmark).

Bexarotene prodrugs: Targeting through cleavage by NQO1 (DT-diaphorase).

Bexarotene, a retinoid X receptor (RXR) agonist, is being tested as a potential disease modifying treatment for neurodegenerative conditions. To limit the peripheral exposure of bexarotene and release it only in the affected areas of the brain, we designed a prodrug strategy based on the enzyme NAD(P)H/quinone oxidoreductase (NQO1) that is elevated in neurodegenerative diseases. A series of indole

Information experiences and needs in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension.

Background. Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are fatal, noncurable, but treatable diseases that strongly affect the patients. Objective. To describe patients' experience of information relating to PAH or CTEPH. Methods. A qualitative method using content analysis was applied. Seventeen patients (thirteen women and four men) aged 28-73

Population-specific Frequencies for LRRK2 Susceptibility Variants in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium

BackgroundVariants within the leucine-rich repeat kinase 2 gene are recognized as the most frequent genetic cause of Parkinson's disease. Leucine-rich repeat kinase 2 variation related to disease susceptibility displays many features that reflect the nature of complex, late-onset sporadic disorders like Parkinson's disease. MethodsThe Genetic Epidemiology of Parkinson's Disease Consortium recently