BackgroundAround 15% of the global population live with some form of disabilities and experience worse health outcomes, less participation in the community and are part of fewer activities outside the home. Outdoor mobility interventions aim to improve the ability to move, travel and orient outside the home and could influence the number of activities outside the home, participation and quality of

Each year, approximately 5000 tons of extraterrestrial material reaches the Earth's surface as micrometeorites, cosmic dust particles ranging from 10 to 2000 μm in size. These micrometeorites, collected from diverse environments, mainly deep-sea sediments, Antarctic ice, snow and loose sediments, and hot deserts, are crucial in understanding our Solar System's evolution. Chrome-rich spinel (Cr-spi

Background: Targeted therapies exploiting vulnerabilities of cancer cells hold promise for improving patient outcome and reducing side-effects of chemotherapy. However, efficacy of precision therapies is limited in part because of tumor cell heterogeneity. A better mechanistic understanding of how drug effect is linked to cancer cell state diversity is crucial for identifying effective combination

Background: Cardiovascular disease (CVD) is a major global health issue, primarily caused by atherosclerosis. Psychological factors may play a role in the development and progression of CVD. However, the relationship between psychological factors and atherosclerosis is complex and poorly understood. This study, therefore, aimed to examine the association of psychological factors with (i) coronary

Inflammation, apoptosis and oxidative stress play crucial roles in the deterioration of severe acute pancreatitis-associated acute respiratory distress syndrome (SAP-ARDS). Unfortunately, despite a high mortality rate of 45 %[1], there are limited treatment options available for ARDS outside of last resort options such as mechanical ventilation and extracorporeal support strategies[2]. This study

Renewable methanol is one of the most promising alternative fuels for internal combustion engines. However, its much higher latent heat of vaporization compared to traditional fossil-based hydrocarbon fuels poses new challenges. On both spark-ignition (SI) engines and dual-fuel (DF) engines, methanol can be introduced through injectors installed in the intake path, with its evaporation then causin

Gambling disorder can be treated with cognitive behavioral therapy (CBT), but treatment is under-dimensioned in many settings. For example, in Sweden, a setting with mixed responsibility for addiction treatment between health care and social services, treatment for gambling disorder has only recently been introduced in the responsibilities of public institutions. After the introduction of gambling

Background: Although several cardiovascular, demographic, genetic and lifestyle factors have been associated with cognitive function, little is known about what type of cognitive impairment they are associated with. The aim was to examine the associations between different risk factors and future memory and attention/executive functions, and their interaction with APOE genotype. Methods: Participa

The distribution of vehicles during a tunnel fire is a crucial factor that affects fire development and hazards, as well as the following evacuation and rescue operations. This work proposed a novel method using computer vision for assessing the real-time tunnel fire risk and evacuation safety by considering the classification and entry flow of vehicles. The proposed system utilizes YOLOv7 and Dee

Background: Parental allergic diseases and smoking influence respiratory disease in the offspring but it is not known whether they influence fractional exhaled nitric oxide (FeNO) in the offspring. We investigated whether parental allergic diseases, parental smoking and FeNO levels in parents were associated with FeNO levels in their offspring. Methods: We studied 609 offspring aged 16–47 years fr

Agricultural intensification and expansion are regarded as main drivers of biodiversity loss. This conclusion is mainly based on observed declines of local diversity (α-diversity), while effects on community composition homogenization (decrease of β-diversity) at a larger spatial scale are less well understood. Carabid beetles and spiders represent two widespread guilds and are important predators

Syftet med denna licentiatavhandling är att bidra till en ökad förståelse för hurräddningstjänsten kan förbättra sin förmåga att lösa komplexa problem vidstorskaliga olyckshändelser. Större olyckor är ofta komplexa och dynamiskahändelser som kännetecknas av en hög grad av osäkerhet, oförutsägbarhet ochtvetydighet. Under sådana förhållanden utmanas räddningstjänstens förmåga att lösa de olika och mGlobal trends suggest an increasing level of uncertainty regarding potential risks faced by individuals, organizations, or society as a whole. These trends are likely to alter the risk landscape, necessitating the enhancement of societal capabilities to effectively address emerging risks. Among the key actors dealing with such changes is the Fire and Rescue Service (FRS). However, these challenges

Changes in land cover, particularly agricultural intensification, are a primary cause of pollinator decline. Decline and isolation can reduce genetic diversity, reducing adaptive potential and unmasking genetic load. Maintenance of functional connectivity in changing landscapes is necessary to ensure persistence, but how land cover impacts genetic diversity and functional connectivity in butterfli

Background: Studies suggest that cerebrospinal fluid (CSF) levels of amyloid-β (Aβ)42 and Aβ40 present a circadian rhythm. However sustained sampling of large volumes of CSF with indwelling intrathecal catheters used in most of these studies might have affected CSF dynamics and thereby confounded the observed fluctuations in the biomarker levels. Methods: We included 38 individuals with either nor

Translation is an essential genetic process for understanding the mechanism of gene expression. Due to the large number of protein sequences generated in the post-genomic era, conventional methods are unable to identify Translation Initiation Site (TIS) in human genes timely and accurately. It is thus highly desirable to develop an automatic and accurate computational model for identification of T

Lewy body (LB) diseases, characterized by the aggregation of misfolded α-synuclein proteins, exhibit notable clinical heterogeneity. This may be due to variations in accumulation patterns of LB neuropathology. Here we apply a data-driven disease progression model to regional neuropathological LB density scores from 814 brain donors with Lewy pathology. We describe three inferred trajectories of LB

Heat Shock Proteins (HSPs) are the substantial ingredients for cell growth and viability, which are found in all living organisms. HSPs manage the process of folding and unfolding of proteins, the quality of newly synthesized proteins and protecting cellular homeostatic processes from environmental stress. On the basis of functionality, HSPs are categorized into six major families namely: (i) HSP2

Background: Mental health problems among adolescents is a global challenge. During the transition to adolescence, physiological, psychological, and social changes occur, leading to increased vulnerability. Thus, adolescent boys are less likely to seek help for mental health problems, which makes them an undetected group. The aim of this study was to gain a deeper understanding of adolescent boys’

We survey the current state of the art in the use of nonparametric methods to test separability. We focus on three tests: Swofford and Whitney's (1994) joint test of the necessary and sufficient conditions for weak separability; Fleissig and Whitney's (2003) sequential test of those conditions; and Jones and Stracca's (2006) test of the necessary and sufficient conditions for additive separability

This book studies the interplay of economic philosophy and moral conduct as reflected in the writings of one of the most renowned scholars in Islamic history, Abū Ḥāmid al-Ghazālī (d. 1111). Al-Ghazālī contributed to Islamic theology, philosophy, and Sufism but is also regarded as one of the forerunners of classical economic thought in Islamic tradition.Al-Ghazālī made seminal contributions to the