The epigenetic "revolution" in science cuts across many disciplines, and it is now one of the fastest-growing research areas in biology. Increasingly, claims are made that epigenetics research represents a move away from the genetic determinism that has been prominent both in biological research and in understandings of the impact of biology on society. We discuss to what extent an epigenetic fram

We present an experimental study of single hole transistors (SHTs) made from p-type GaSb nanowires. Closely spaced source-drain electrodes are fabricated onto GaSb nanowires to define a SHT within a GaSb nanowire. Room temperature back-gate transfer characteristics show typical hole transport behavior. The fabricated devices are characterized by transport measurements at 1.5 K, where periodic cond

Rivaroxaban is a direct factor Xa inhibitor that is widely available to reduce the risk of stroke or systemic embolism in patients with nonvalvular atrial fibrillation and one or more risk factors for stroke. Rivaroxaban provides practical advantages compared with warfarin and other vitamin K antagonists, including a rapid onset of action, few drug interactions, no dietary interactions, a predicta

The t (t) over bar production cross-section dependence on jet multiplicity and jet transverse momentum is reported for proton-proton collisions at a centre-of-mass energy of 7 TeV in the single-lepton channel. The data were collected with the ATLAS detector at the CERN Large Hadron Collider and comprise the full 2011 data sample corresponding to an integrated luminosity of 4.6 fb(-1). Differential

A distributed model predictive control (DMPC) approach based on distributed optimization is applied to the power reference tracking problem of a hydro power valley (HPV) system. The applied optimization algorithm is based on accelerated gradient methods and achieves a convergence rate of O(1/k^2), where k is the iteration number. Major challenges in the control of the HPV include a nonlinear and l

This study investigated the extent to which perceived physical and social-environment qualities of supported housing facilities (SHF) account for variations in the perceived quality of life of people with severe mental illness (SMI). Based on a user-centered approach, people with SMI (N = 72) appraised the environment of their SHF (N = 20). Moreover, it investigated whether place attachment played

The aging of the population is a worldwide trend, especially in Western countries. The increased number of people living past 65 years is also a trend for polypharmacy (the multiple use of medication) among elderly people. In terms of market orientation, the pharmaceutical industry is well-developed, but the same cannot be said in terms of design orientation. Previous studies indicate that packagi

Background: Adequate bowel preparation prior to colonic diagnostic procedures is essential to ensure adequate visualisation. Scope: This consensus aims to provide guidance as to the appropriate use of bowel preparation for a range of defined clinical circumstances. A consensus group from across Europe was convened and met to discuss appropriate bowel preparation. The use of polyethylene glycol (PE

Rising organic matter concentrations in surface waters in many Nordic countries require current drinking water treatment processes to be adapted. Accordingly, the use of a novel nanofiltration (NF) membrane was studied during a nine month period in pilot scale at a large drinking water treatment plant in Stockholm, Sweden. A chemically resistant hollow-fibre NF membrane was fed with full scale pro

Rapid control of bleeding is the key to reducing bleeding complications and thereby preserving joint and musculoskeletal function in haemophilia patients with inhibitors. However, this requires early diagnosis following the onset of bleeding and strategies for rapid treatment in an outpatient setting. Overarching themes on the need for speed in managing bleeds in haemophilia patients were examined

Abstract in UndeterminedThis study deals with a current problem of urban human-biometeorology on the micro-scale, which becomes more important due to the future increase of severe summer heat in Central Europe. The impact of street design parameters on the thermal comfort of citizens is analysed in an experimental way for typical summer conditions in Central Europe. The investigation is focused on

Mosasaurs are an extinct group of secondarily adapted aquatic lizards that became the dominant marine tetrapods in the Late Cretaceous oceans. They continuously shed and replaced their teeth in order to maintain a functional dentition at all times; however, the process of tooth development in mosasaurs is still incompletely known. Based on incremental line width measurements and growth line counts

Exposure to Ljungan virus (LV) is implicated in the risk of autoimmune (type 1) diabetes but possible contribution by other parechoviruses is not ruled out. The aim was to compare children diagnosed with type 1 diabetes in 2005-2011 (n = 69) with healthy controls (n = 294), all from the Jämtland County in Sweden, using an exploratory suspension multiplex immunoassay for IgM and IgG against 26 pept

We perform time-dependent local density functional calculations of the time delay in C-60 HOMO and HOMO-1 photoionization at giant plasmon energies. A semiclassical model is used to develop further insights.

Previous experience has demonstrated the importance of testing new bone cement in vivo before widespread clinical use. We performed a consecutive, radiostereometric (RSA) study comparing Refobacin Bone Cement (RBC) to the well proven Palacos with Gentamicin (PWG). According to the manufacturer of RBC it has the equivalent characteristics as PWG, and in vitro tests show good results. The purpose of

Intake of dairy products has been associated with risk of some cancers, but findings are often inconsistent and information on hepatocellular carcinoma (HCC) risk is limited, particularly from prospective settings. The aim of our study was to investigate the association between consumption of total and specific dairy products (milk/cheese/ yogurt) and their components (calcium/vitamin D/fats/prote

BACKGROUND:To investigate the dermal uptake of 4,4'-diphenylmethane diisocyanate (4,4'-MDI), a study was performed in which 2 female volunteers were exposed to 10 and 25 mg, respectively, of 4,4'-MDI by applying 2.0% 4,4'-MDI in petrolatum over areas where the surface concentration corresponded to 800 µg/cm(2) . Ten days later, they developed eczematous dermatitis at the area of application.OBJECT