The polyamines are polycationic compounds essential for cellular proliferation and transformation. In addition to a well-defined biosynthesis pathway, polyamines are internalized into cells by as yet incompletely defined mechanisms. Numerous reports have shown that efficient polyamine uptake depends on the presence of polyanionic, cell surface-associated heparan sulfate proteoglycans (HSPGs). In t

For the modified Hughes procedure, a tarsoconjunctival flap from the upper eyelid is used to reconstruct large, full-thickness, lower eyelid defects. The conjunctival pedicle is divided once vascularization is deemed to be adequate. The importance of maintaining a flap pedicle to ensure adequate perfusion of the graft has been questioned. The purpose of the study was to investigate the microvascul

In the present study, we hypothesized that changes in perfusion pressure result in altered expression of mRNA and protein encoding for the ETA-, ETB-, AT1- and AT2-receptors in rat mesenteric vessels. Segments of the rat mesenteric artery were cannulated with glass micropipettes, pressurized and luminally perfused in a perfusion chamber. After either exposure to no ("organ culture" (0 mmHg)), norm

Understanding how cells polarize and coordinate tubulogenesis during organ formation is a central question in biology. Tubulogenesis often coincides with cell-lineage specification during organ development. Hence, an elementary question is whether these two processes are independently controlled, or whether proper cell specification depends on formation of tubes. To address these fundamental quest

OBJECTIVE: Statistical analysis is ubiquitous in medical research, but fundamental statistical principles are not always well understood, which has negative effects for both authors and readers of scientific papers. The purpose of this brief review is to provide a methodological overview on populations, samples, analysis units and sampling uncertainty to facilitate an increased understanding of st

In this study, cell nuclei from aneuploid breast cancer samples were sorted with respect to DNA content into pure diploid and aneuploid fractions using flow cytometry. The nuclear proteins were then separated by one-dimensional gel electrophoresis (1D-PAGE) and differences in protein expression patterns, between diploid and aneuploid nuclei from the same tumours, were compared. Using a combination

The article argues that contemporary protest movements are facing a convergence of what has traditionally been coined as mainstream and alternative media. Traditionally, the broad term ‘alternative media’ has been employed to embrace a wide range of oppositional media channels that can be considered to carry on the tradition of the early radical and party press: micro-media operating at the grassr

Popular Abstract in Swedish Hur många betydelser har etnicitet i polisens arbete? Diskriminering och främlingsfientlighet är kanske det första många tänker på. Men kan etnicitet innebära mer än så i polisens arbete? Och är det alltid poliserna som för in den etniska dimensionen i mötet med medborgaren? Denna etnografiska studie beskriver dussintals betydelser av etnicitet i polisens vardag. Vi möThis thesis analyzes how ethnicity is accomplished in the work of Swedish police officers. It draws on ethnographic data from participant observations and field interviews in Malmö and its theoretical framework is primarily based on ethnomethodology. Police officers – and others in their environment – are found to employ ethnicity and invoke it into interactions in a variety of ways: 1) redefining

En öppen stor samtalsgrupp med upp till 50 personer med kognitiv beteendeinriktning för långtidssjukskrivna smärtpatienter ger rehabiliteringseffekter i form av minskad smärta och smärtpåverkan, ökad subjektiv hälsoupplevelse och minskad vård- och läkemedelskonsumtion. I och med att gruppen är öppen kan patienterna rehabilitera sig i sin egen takt, vilket upplevs mycket positivt av målgruppen. Reh