Popular Abstract in Swedish Det enteriska nervsystemet (ENS) utgör mag-tarmkanalens eget nervsystem, ibland refererat till som “the second brain” då det uppvisar stora likheter med det centrala nervsystemet (CNS). Rubbningar i ENS ger bland annat störningar i tarmens motorik. Denna avhandling handlar om två sjukdomar i mag-tarmkanalen hos barn som bägge är uttryck för en rubbad motorik; HirschspruGastrointestinal motility disorders are common in childhood and in this thesis we look at two of them, i.e. Hirschsprung´s Disease (HD) and gastroesophageal reflux disease (GERD) in five different studies. HD is a congenital disease characterized by an abscence of ganglion cells in myenteric and submucous ganglia, most commonly in the distal part of the large bowel. In Paper I, we have studied th

Melanohalea olivacea rarely occurs on the lower, snow-covered parts of the birch stems in subarctic Sweden, where Parmeliopsis ambigua can persist thanks to its larger reserves of lipids. In contrast, P. ambigua is outcompeted by M. olivacea higher up on the stems because of its lower growth rate.

This paper reports the draft genome sequence of the firmicute Geobacillus sp. strain ZGt-1, an antibacterial peptide producer isolated from the Zara hot spring in Jordan. This study is the first report on genomic data from a thermophilic bacterial strain isolated in Jordan.

Background: Tryptophanyl-tRNA synthetase (TrpRS) is an aminoacyl-tRNA synthetase involved in protein synthesis and regulation of RNA transcription and translation and is an inhibitor of angiogenesis. TrpRS has been shown to be differentially expressed in colorectal cancer (CRC) and has thus been identified as a potential prognostic marker. The aim of this study was to analyze the correlation of Tr

Abstract in German Die Reaktionen auf die NS-Rassenpolitik in Schweden sind insofern besonders interessant, da Schweden weder besetzt, noch aliiert, noch kriegführend war. Die Folgen der deutschen Politik waren darum auf der einen Seite selbstverständlich viel indirekter als in den stärker unmittelbar berührten Staaten. Andererseits haben neueste Untersuchungen ergeben, dass viele Menschen auch im

Background Starting in the 1960s, a broad-based patients’ rights movement began to question doctors’ paternalism and to demand disclosure of medical information, informed consent, and active participation by the individual in personal health care. According to scholars, these changes contributed to downplay the biomedical approach in favor of a more patient-oriented perspective. The Swedish non-p

Background: Procedures documented by general practitioners in primary care have not been studied in relation to procedure coding systems. We aimed to describe procedures documented by Swedish general practitioners in electronic patient records and to compare them to the Swedish Classification of Health Interventions (KVA) and SNOMED CT. Methods: Procedures in 200 record entries were identified, co

Popular Abstract in Swedish Med stigande ålder försvagas våra vävnader. Om bukväggen i ljumsken blir för svag, så kan bukinnehållet pressas ut genom svagheten. Detta kallas för ljumskbråck. Sjukdomen är mycket vanligare hos män och drabbar alla åldrar. Ju äldre man är, desto vanligare att man drabbas av ett ljumskbråck. Man upplever då, framför allt vid ansträngning, en oftast rörlig och ibland smBackground: In the nineties, the patients with inguinal hernias were exposed to several newly developed repair techniques using alloplastic mesh prosthesis. Although the scientific knowledge was limited, the new techniques were rapidly introduced due to surgical enthusiasm, but also by an eagerness to reduce the recurrence rate and to shorten the time to recovery. When the first study of this thes

OBJECTIVETo identify the clinical and genetic factors that explain why the rate of diabetes progression is highly variable between idividuals following diagnosis of type 2 diabetes.RESEARCH DESIGN AND METHODSWe studied 5,250 patients with type 2 diabetes using comprehensive electronic medical records in Tayside, Scotland, from 1992 onward. We investigated the association of clinical, biochemical,

Treatment with melphalan-prednisone-thalidomide improves the outcome of patients with multiple myeloma and is now considered a standard of care for patients not eligible for transplantation. However, this treatment is a major source of morbidity. A meta-analysis of data from individual patients (n=1680) in six randomized trials was performed, comparing the effects of melphalan-prednisone-thalidomi

Inom hälso- och sjukvården i Sverige implementeras ständigt nya styrmodeller. Många av dessa ger dock inte avsett resultat. I kapitlet diskuteras varför och hur styrmodeller omtolkas där kvalitetssäkring används som illustrativt exempel.

In this technical note we introduce a multivariable extension of a recently proposed model reduction algorithm for linear time-invariant systems. Reduced models are found by solving a convex. optimization problem with Linear Matrix Inequality constraints given a state space model or frequency samples of a model. In order to illustrate the method we apply it to a large-scale model of a deformable m

It has been suggested that transcriptional upregulation of cerebral artery contractile endothelin (ETB) and 5-hydroxytryptamine (5-HT1B) receptors play an important role in the development of late cerebral ischemia and increased vasoconstriction after subarachnoid hemorrhage (SAH). We tested the hypothesis that inhibition of calcium calmodulin-dependent protein kinase II (CaMKII) may reduce cerebr

It is increasingly recognized that what makes a theory interesting and influential is that it challenges our assumptions in some significant way. However, established ways for arriving at research questions mean spotting or constructing gaps in existing theories rather than challenging their assumptions. We propose problematization as a methodology for identifying and challenging assumptions under

Refined mineral oil, intended for various technical applications, was enriched with carotenoids by supercritical carbon dioxide extraction using the oil itself as cosolvent. It was envisioned that the carotenoids could function as renewable oil additives, adding chemical functionality to the end product such as enhanced resistance to oxidation. In order to investigate such possible antioxidant act

Background: Tumour necrosis factor-alpha (TNF-alpha) is a pleiotropic pro-inflammatory cytokine, which is rapidly upregulated in the brain after injury. TNF-alpha acts by binding to its receptors, TNF-R1 (p55) and TNF-R2 (p75), on the cell surface. The aim of this study was first to investigate if there is altered expression of TNF-alpha and TNF-alpha receptors in cerebral artery walls following g