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MOTIVATION: Neutrophil extracellular traps (NETs) are believed to be essential in controlling several bacterial pathogens. Quantification of NETs in vitro is an important tool in studies aiming to clarify the biological and chemical factors contributing to NET production, stabilization and degradation. This estimation can be performed on the basis of fluorescent microscopy images using appropriate

Streptococcus suis is an important cause of different pathologies in pigs and humans, most importantly fibrinosuppurative meningitis. Tissue infected with this pathogen is substantially infiltrated with neutrophils, but the function of neutrophil extracellular traps (NETs) - a more recently discovered antimicrobial strategy of neutrophils - in host defence against Strep. suis has not been investig

The porcine and human pathogen Streptococcus suis induces and degrades neutrophil extracellular traps (NETs) in vitro. In this study, we investigated the working hypothesis that NET degradation is mediated not only by the known secreted S. suis nuclease A (SsnA) but also by a so-far undescribed putative endonuclease A of S. suis (designated EndAsuis) homologous to the pneumococcal endonuclease A (

Neutrophil extracellular trap (NET) formation is described as a tool of the innate host defence to fight against invading pathogens. Fibre-like DNA structures associated with proteins such as histones, cell-specific enzymes and antimicrobial peptides are released, thereby entrapping invading pathogens. It has been reported that several bacteria are able to degrade NETs by nucleases and thus evade

The formation of neutrophil extracellular traps (NETs) as a host innate immune defence mechanism has been shown to be the result of a novel cell death process called NETosis. The objective of this study was to investigate the role of cholesterol in the formation of NETs. To this end, primary human neutrophils were treated with different concentrations of methy-β-cyclodetxrin (MβCD) to reduce chole

Beskrivning och analys av spex (särskilt de lundensiska) som litterär-scenisk genre.

Första delen av en biografisk skildring av Jacob "Svasse" Bergqvist (1887-1959), jur kand vid Lunds universitet, statstjänsteman och revyförfattare.

Glomalin-related soil protein (GRSP) is known as an important microbial by-product which is crucial for preserving or accumulating soil organic carbon (SOC). However, the underlying mechanisms are not well understood. In this study, we investigated the chemical structures of GRSP and its relationship with SOC using 13C nuclear magnetic resonance (NMR) in three tropical forests. The three forests,

Managing entrepreneurship is of importance for the society, for organizations and for the individual. It is not enough with knowledge and skills relating to the idea behind entrepreneurship. The entrepreneur must have knowledge and skills to manage the entrepreneurial process. The purpose of this paper is to put forward for agile project management as an appropriate way to manage an entrepreneuria

In this paper we are investigating how project complexity is affecting the management of single projects in a multi-project environment. The project manager’s perspective is applied. A conceptual framework is developed in order to summarize how project complexity effect project management. The framework is applied to two cases and conclusions are drawn.

BACKGROUND: Aquaporins (AQPs) are integral membrane proteins that facilitate transport of water and/or other small neutral solutes across membranes in all forms of life. The X Intrinsic Proteins (XIPs) are the most recently recognized and the least characterized aquaporin subfamily in higher plants. XIP1s have been shown to be impermeable to water but permeable to boric acid, glycerol, hydrogen pe

Project costing is an area where more research is needed. Beginning from typical project characteristics discusses the specific costing problems of the project. The focus is on how those problems can be managed using activity-based costing. The article also takes up a short discussion about the critical moments of the project costing.

We present an approach towards four dimensional (4d) movies of materials, showing dynamic processes within the entire 3d structure. The method is based on tomographic reconstruction on dynamically curved paths using a motion model estimated by optical flow techniques, considerably reducing the typical motion artefacts of dynamic tomography. At the same time we exploit x-ray phase contrast based on

Metallic cast components inevitably contain defects such as shrinkage cavities which are inherent to the solidification process. Those defects are known to significantly alter the fatigue life of components. Yet very little is known, quantitatively, on the dangerosity of internal casting defects compared to surface ones. In this study, fatigue specimens containing controlled internal defects (shri

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Water drainage from porous media is a highly dynamic process often marked by rapid piston-like air invasion events at the front and other rapid interfacial reconfigurations. Liquid phase entrapped behind the moving front drains at significantly slower rates often via gravity driven flow through corners and crevices. This distribution of slowly draining residual water phase determines the plant ava

Series of fast synchrotron X-ray tomographies are taken continuously at a rate of up to 5Hz, while aluminium alloy precursors are foamed in an X-ray transparent setup for several minutes using infra-red (IR) lasers for heating. The entire foaming process from the solid precursor to the expanded liquid foam is captured. The analysis of the sequence of tomographies is done with an emphasis on nuclea