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Background: Cardiovascular disease (CVD) is the leading cause of mortality in type 2 diabetes mellitus (T2DM) patients. Shrunken pore syndrome (SPS) is defined as eGFRcystatin C/eGFRcreatinine ratio <0.70 and predicts high CVD mortality. The Framingham Risk Score (FRS) is used to estimate an individual’s 10-year CVD risk. This study investigated the association between FRS and eGFRcystatin C/eGFRc

Background: In light of increasing therapeutic options, risk stratification of advanced cardiac transthyretin amyloidosis (ATTR-CA) is gaining clinical importance to avoid ineffective treatments. Liver stiffness as a marker of hypervolemia and hepatic congestion might predict mortality in advanced ATTR-CA and allow to identify patients at highest risk. Methods: Proven ATTR-CA patients underwent re

Inconel 718 represents a large portion of high-temperature metals in key industries, where the machining-induced surface integrity is quite important. As the different grain size results in various densities of grain boundaries in the deformed area, the surface integrity can be significantly affected. This paper studies the effect of workpiece grain size on machining-induced surface integrity when

BACKGROUND: There is increasing evidence implicating hemoglobin/heme and their scavengers in oxidative stress-mediated pathologies, but information is limited in abdominal aortic aneurysm (AAA).METHODS AND RESULTS: In this case-control study, we assessed heme/heme-related markers in 142 men with AAA and 279 men with a normal aortic diameter consecutively recruited from an ultrasound screening prog

This paper presents an overview of the literature on universal design for equitable healthcare. The central inquiry in the current paper is a critical design-for-all challenge: how might universal design contribute to providing equitable healthcare for women suffering from pelvic floor injuries during birth? This study delves into some of the explicit and implicit needs of this deprioritized minorThis paper presents an overview of the literature on universal design for equitable healthcare. The central inquiry in the current paper is a critical design-for-all challenge: how might universal design contribute to providing equitable healthcare for women suffering from pelvic floor injuries during birth? This study delves into some of the explicit and implicit needs of this deprioritized minor

The present study illustrates the microphysical parameters of nimbostratus clouds during the Indian summer monsoon using airborne and radar observations conducted as part of the Cloud Aerosol Interaction and Precipitation Enhancement Experiment (CAIPEEX), and simulations with the Weather Research and Forecasting (WRF) model. The study also analyzes the impact of secondary ice production (emphasizi

The sPHENIX Time Projection Chamber Outer Tracker (TPOT) is a Micromegas based detector. It is a part of the sPHENIX experiment that aims to facilitate the calibration of the Time Projection Chamber, in particular the correction of the time-averaged and beam-induced distortions of the electron drift. This paper describes the detector mission, setup, construction, installation, commissioning and pe

Based on the Shidi-1 drill core, this paper presents new and highly time resolved carbon isotope data (δ13Ccarb) for the Early Ordovician through Early Silurian of the Yangtze Platform, South China. Five carbon isotopic shifts (C1-C5) through the late Tremadocian to the Katian have been recognized in the Shidi-1 drill core recordings. Together with previously published isotope data, a composite ca

This essay discusses the notion of 'semiotic development in child development' and highlights potential concerns for 'psychologism' when semiotics turns into cognitive semiotics. The notion of 'semiotic development in child development' indicates a transdisciplinary approach involving both semiotics, the general study of meaning and signs, and child psychology. This, however, invites the criticism

Astrocytes play key roles in the brain. When astrocyte support fails, neurological disorders follow, resulting in disrupted synaptic communication, neuronal degeneration, and cell death. We posit that astrocytes overexpressing neurotrophic factors, such as Insulin Like Growth Factor 1 (IGF1), prevent the onset of neurodegeneration. We overexpressed IGF1 and the reporter TdTomato (TOM) in hippocamp

A search for charged-lepton-flavor violating Formula Presented (Formula Presented, Formula Presented) interactions is presented, considering both top-quark production and decay. The data analyzed correspond to Formula Presented of proton-proton collisions at a center-of-mass energy of Formula Presented recorded with the ATLAS detector at the Large Hadron Collider. The analysis targets events conta

Craft has been a steady adversary to the proliferation of industrialization. As an imaginary of embodied work, mainly driven by intrinsic motivation and by a strive for excellence, craft is increasingly re-emerging in discussions on improving current forms of work. A common theme across research on craft is its potential to address alienation as one of the main pathologies of modern work. We study

Structural systems in seismic-prone regions can experience sudden deterioration caused by earthquake-induced ground-motion sequences. In addition, given the prevailing environmental conditions at their site, these systems may undergo gradual deterioration resulting from environment-induced mechanisms. The combined impacts of such phenomena can result in significant structural/non-structural damage

The deterioration of engineering systems might reduce the system reliability and prompt maintenance operations that may disrupt the ability of the systems to provide regular service. Estimating the Remaining Useful Life (RUL) of the system requires an understanding of the deterioration processes acting on it. Recent formulations have shifted the focus of deterioration modeling from the system as a