Search results

Filter

Filetype

Your search for "*" yielded 528661 hits

Grassroots initiatives transforming cities toward post-growth futures : Insights from the collaborative economy movement in Gothenburg, Sweden

Grassroots initiatives (GIs) are local, yet globally connected networks of activists that generate novel solutions for sustainability. While GIs are often claimed to play an important role for urban sustainability transitions, little research has examined how such innovations consolidate beyond isolated local initiatives. This article summarizes findings from a case study of the collaborative econ

Narrative and discursive approaches in entrepreneurship : A second movements in entrepreneurship book

'Daniel Hjorth and Chris Steyaert set out to advance the study of entrepreneurship by refocusing the lens of discovery from economics, management and marketing to other paradigmatic stances in social sciences and humanities like anthropology and literary studies. The result is a provocative collection of chapters that inspire the reader to consider and explore new ideas and research practice that

Creating space for play/invention - Concepts of space and organizational entrepreneurship

This paper focuses on how one can relate management thinking/practices to entrepreneurial processes in the context of formal organization. In order to do this we develop a number of related 'spatial concepts' providing us with the possibility of describing entrepreneurship as a 'creation and use of space for play/innovation'. Using concepts of space, the managerial and the entrepreneurial dimensio

New movements in entrepreneurship

'Drawing from contributions by scholars of entrepreneurship from North America, Western Europe and Asia, this edited book celebrates the vibrancy and interdisciplinarity of entrepreneurship research. It showcases the renewed importance of entrepreneurship studies in the social sciences. New Movements in Entrepreneurship is a tour de force in entrepreneurship studies that must not be missed. It's b

‘Thou Art a Scholar, Speak to it..’ - on Spaces of Speech : A Script

This article argues, based on the work of Bakhtin and de Certeau, that there is no aesthetics without politics and that all academic discourse and practices are enacted through aesthetic forms with inherently political and ethical effects. The article is written in a script-form with indications on how to perform it, acting out or ‘performing’ in a direct way rather than adding to the arguments al

Inflammatory bowel disease induces pathological α-synuclein aggregation in the human gut and brain

Aims: According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) in humans can progress with the emergence of pathogenic α-synuclein (α-syn) in the gastrointestinal tract and midbrain dopaminergic neurons. Methods:

How learning spaces matter in entrepreneurship education : introducing the concept of topopraxis

Research into entrepreneurship education has explored content, audience and pedagogy but much is still to be studied when it comes to the spatial dimensions of learning–that is, where entrepreneurship is taught, how this matters for pedagogies used, and the implications for learning. We seek to strengthen a theoretical foundation for understanding learning spaces and the spatial dimensions in entr

Organizational and Institutional Entrepreneuring : Introduction to the Special Issue

In our Introduction to this Special Issue on Organizational and Institutional Entrepreneuring, we draw attention to the importance of recognizing how processes and practices of entrepreneuring take place in the context of an already organized world. We particularly draw attention to how such entrepreneuring processes, as imaginative-poetic extensions beyond the present, can occur in a variety of s

Stirring and disturb - urging the movement of academic entrepreneurship onwards

In an epilogue, Daniel Hjorth and Chris Steyaert aim to further multiply the new movements in academic entrepreneurship that this volume identifies. Therefore, they introduce a conceptual quartet that makes and keeps movement going: provocation, mobilization, affirmation, and experimentation. Their conceptual contribution, which has to be seen as an attempt to stir and disturb, relates these four

Entrepreneurial intermediation in innovation : A study of multilayered contexts and embedded dynamics of organisation-creation

The article is based on a theoretical exploration and empirical analysis of formalized public initiated instruments—eight network entrepreneurs—intended to promote, intermediate and support innovation and entrepreneurship in firms and firm networks located in three different business areas in Mid-Norway: food value chain, experience industries, and renewable energy and environmental technology. Th

6-bromoindirubin-3’-oxime promotes osteogenic differentiation of canine BMSCs through inhibition of GSK3β activity and activation of the Wnt/β-catenin signaling pathway

This study aimed to investigate how 6-bromoindirubin-3’-oxime (BIO) increases the osteogenic differentiation of canine bone mesenchymal stem cells (BMSCs) and the role of the Wnt/β-catenin signaling pathway in this process. We mimicked the effect of Wnt by adding BIO to the culture medium of BMSCs and examined whether canonical Wnt signaling positively affects the differentiation of these cells in

Tryptophan and kynurenine stimulate human decidualization via activating Aryl hydrocarbon receptor : Short title: Kynurenine action on human decidualization

Decidualization is essential for successful pregnancy in rodents and primates. Although L-Tryptophan and its metabolites are essential for mammalian pregnancy, the underlying mechanism is poorly defined. We explored effects of tryptophan and kynurenine on human in vitro decidualization in human endometrial stromal cell line and primary endometrial stromal cells. Tryptophan significantly stimulates

Regulation and function of laminin A5 during mouse and human decidualization

Decidualization is essential to the establishment of pregnancy in rodents and primates. Laminin A5 (encoding by Laminin α5) is a member of the laminin family, which is mainly expressed in the basement membranes. Although laminins regulate cellular phenotype maintenance, adhe-sion, migration, growth, and differentiation, the expression, function, and regulation of laminin A5 during early pregnancy

The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization

Introduction: High-mobility group box 1 (HMGB1) is a non-histone nuclear protein and can be extracellularly secreted to induce sterile inflammation. Although uterine deletion of HMGB1 causes implantation and decidualization defects, how secreted HMGB1 is involved in mouse early pregnancy is still unknown. Methods: Mouse models, mouse primary endometrial cells and human endometrial cell lines were

Multi-template analysis of human perirhinal cortex in brain MRI : Explicitly accounting for anatomical variability

RATIONAL: The human perirhinal cortex (PRC) plays critical roles in episodic and semantic memory and visual perception. The PRC consists of Brodmann areas 35 and 36 (BA35, BA36). In Alzheimer's disease (AD), BA35 is the first cortical site affected by neurofibrillary tangle pathology, which is closely linked to neural injury in AD. Large anatomical variability, manifested in the form of different

Expression and Regulation of a Novel Decidual Cells-Derived Estrogen Target during Decidualization

During decidualization in rodents, uterine stromal cells undergo extensive reprogramming to differentiate into distinct cell types, forming primary decidual zones (PDZs), secondary decidual zones (SDZs), and layers of undifferentiated stromal cells. The formation of secondary decidual zones is accompanied by extensive angiogenesis. During early pregnancy, besides ovarian estrogen, de novo synthesi