Human malignancies are often hallmarked with genomic instability, which itself is also considered a causative event in malignant transformation. Genomic instability may manifest itself as genetic changes in the nucleotide sequence of DNA, or as structural or numerical changes of chromosomes. Unrepaired or insufficiently repaired DNA double-strand breaks, as well as telomere shortening, are importa

This paper takes a detailed look at some popular models of evolution used in contemporary diachronic linguistic research, focusing on the continuous-time Markov model, a particularly popular choice. I provide an exposition of the math underlying the CTM model, seldom discussed in linguistic papers. I show that in some work, a lack of explicit reference to the underlying computation creates some di

Cancer is mostly incurable when diagnosed at a metastatic stage, making its early detection via blood proteins of immense clinical interest. Proteomic changes in tumor tissue may lead to changes detectable in the protein composition of circulating blood plasma. Using a proteomic workflow combining N-glycosite enrichment and SWATH mass spectrometry, we generate a data resource of 284 blood samples

Droplet microfluidics has emerged as a promising platform for miniaturisation of biological assays on-chip. In droplet microfluidics small water droplets (nL-pL) surrounded by an immiscible carrier oil are generated at high throughput. In these droplets particles such as cells or microbeads can be encapsulated, and the idea is that each of these droplets can be used as small reaction chambers for

High circulating nonesterified fatty acids (NEFAs) concentration, often reported in diabetes, leads to impaired glucose-stimulated insulin secretion (GSIS) through not yet well-defined mechanisms. Serotonin and dopamine might contribute to NEFA-dependent β-cell dysfunction, since extracellular signal of these monoamines decreases GSIS. Moreover, palmitate-treated β-cells may enhance the expression

Aims Pancreatic β-cells synthesize and release serotonin (5 hydroxytryptamine, 5HT); however, the role of 5HT receptors on glucose stimulated insulin secretion (GSIS) and the mechanisms mediating this function is not fully understood. The aims of this study were to determine the expression profile of 5HT receptors in murine MIN6 β-cells and to examine the effects of pharmacological activation of 5

Background: Increased blood pressure is the biggest contributor to the global burden of disease and mortality. Data suggest that less than half of the population with hypertension is aware of it. May Measurement Month was initiated to raise awareness of the importance of blood pressure and as a pragmatic interim solution to the shortfall in screening programmes. Methods: This cross-sectional surve

On‐bill financing (OBF) schemes have been welcomed as innovative mechanisms for encouraging the adoption of low‐carbon energy technologies. Yet while the potential effects of these schemes have received growing attention, less is known about their actual performance. Departing from New Institutional Economics and insights from Behavioral Economics, this theory‐driven assessment examines the How$ma

The exact physiological role for the monoamine serotonin (5-HT) in modulation of insulin secretion is yet to be fully understood. Although the presence of this monoamine in islets of Langerhans is well established, it is only with recent advances that the complex signaling network in islets involving 5-HT is being unraveled. With more than fourteen different 5-HT receptors expressed in human islet

BACKGROUND: Hyperthyroidism is associated with alterations in metabolism that are currently only partially understood. The objective of the study was to investigate changes in metabolism associated with reinstatement of euthyroidism in Swedish patients.METHODS: Eighty metabolites in plasma were profiled from 10 subjects with Graves' disease (GD) at baseline and after 9 and 15 months of treatment t

Feedback control is increasingly being applied in server systems to make them more robust and efficient. This includes managing quality of service, minimizing power consumption, and adapting to varying workloads. Successful adaptation and control in turn relies on accurate tracking of workload variations and timely detection of changes in the computing infrastructure. Given that server systems are

Elemental Carbon (EC) has been in focus for a long time due to its importance for climate effects and human health (WHO / IPCC). The pollutant is released by incomplete combustion of carbon fuels, making road traffic, off-road machinery, and wood stove burning the largest sources of EC emissions. In this work, we investigate the distribution of EC over Denmark using a combination of three models w

The term Bildung did not exist in the Reformation era. Rather, one spoke of "the Learned World." Coming up in the Renaissance, the Reformation was influenced by humanism and its prominent figures Johann Reuchlin and Erasmus of Rotterdam and their interest in the classical heritage with Latin as the scholarly lingua franca. Both Luther and Melanchthon attached themselves directly to that tradition

The article shows how Luther understood music as permeating everything in Creation, as God's gift, as donum, and as an invitation to praise and participation. For him, music and the love of Christ is expressed as loving embrace, inviting mutuality, participation, permeating life, in ways close to mysticism.