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Performance testing of in silico HLA typing tools using a validated next generation sequencing data set, and identification of HLA allele restricted tumour neo-antigens

Datoranalys av cellernas eget flagg-system kan bidra till forskningen kring patient-anpassade cancerbehandlingar Tänk dig att du zoomar in på cellytan utav dina celler. Något som du kommer lägga märke till är uppradade molekyler med små utstickande protein-stumpar (peptider). De står nästan som flaggstänger med viftande flaggor i olika former. Dessa ”flaggstänger” kallas för MHC molekyler och de The exceptionally polymorphic Human Leukocyte Antigen (HLA) genes play a crucial role in the immune system’s interplay with non-immune cells. Certain HLA alleles are known to have a strong disease correlation. There is a growing interest, within several research fields, in determining (typing) HLA alleles at higher resolution than what is possible today using standard laboratory methods. Within th

The role of SRC-like adaptor protein 2 (SLAP2) in receptor tyrosine kinase KIT signaling

SLAP2: A potential new strategy in fighting cancer Among more than 20,000 genes in humans, about 2% of genes encode a class of proteins referred to as kinases. A kinase is a protein, which transfers phosphate groups to proteins called substrate proteins. This process is named phosphorylation and almost all cellular behaviors are controlled by protein phosphorylation. Kinases mainly phosphorylate

Using Old Tires as 3D-Printing Material

Like with printers, material used for 3D­printing is what makes it expensive, especially if the printer is meant to be low­cost. Can used tires be the solution? This thesis proves that old tires can be turned into a usable granulate, with simple means. Then 3D­printing could be made accessible to people of lesser means.

Internet-of-Things in Low Voltage Electricity Grids

When evaluating future technologies for smart metering and automatic meter reading (AMR) E.ON Elnät Sverige AB has set up a pilot to test a communication technology supplied by Connode AB. Connode have developed a mesh radio solution based on 6LoWPAN, IPv6 over Low Powered Wireless Personal Area Network. By using this technology the communication unit on every meter is acting as both receiver and

Actors in Innovation

Innovation is gospel today. This also means a surge in popularity for the agents behind innovation; innovators. But who are they, exactly? Anecdotal evidence from both recent times and historical settings tend to emphasize remarkable individuals, who more or less alone created amazing things. By utilizing the SWINNO-database of innovations, this thesis examines how empirically prevalent the narrat

Optimization and Control Properties for a Dividing Wall Distillation Column

Dividing wall columns are single shell distillation columns which are thermally fully coupled. DWC has the ability to create three product streams from one feed stream. A simulation of DWCs is hard due to the complexity of the system. Unfortunately, there is no good software package that can be used for simulations. Instead a detailed flowsheet with the right components and good arrangement over t

Effektförluster från ventilationskanaler

I en allt mer energieffektiv värld så spelar allt fler av energiförlusterna allt större roll. Tidigare hade man samma förluster som idag från kanalsystemet men de totala förlusterna var större. När man nu har minskat andra förluster i huset får kanalför- lusterna en allt större betydelse i den totala energianvändningen, vilket leder till att det nu finns anledning att ta större hänsyn till dem. I To minimize energy losses becomes more and more important in a world where energy efficiency is a big priority and necessary if we want a future on our planet. The relative impact from ducting losses on the energy performance of the building was earlier so small that it was plausible to ignore them. Nowadays many of the other parts of the losses have been cut which means the air ducts now might st

Does remembering the past lead to forgetting of future intentions? Retrieval-induced forgetting in retrospective and prospective memory in young and old adults

Retrieval-induced forgetting (RIF) refers to the phenomenon that selective retrieval of some information impairs memory for related, but not previously retrieved information. Despite age differences in retrieval-induced forgetting regarding retrospective memory being documented, the current literature lacks studies examining age differences in RIF of the prospective memory tasks. This study compar

Vindsombyggnader i flerbostadshus från 1900-talets början

Ett högaktuellt problem i Sverige är bristen på bostäder. Framförallt saknas små bostäder för unga. Ett sätt att öka antalet små bostäder är att bygga om outnyttjade vindar i befintligt bo- stadsbestånd till små lägenheter. För att underlätta denna typ av ombyggnader röstade Sveri- ges riksdag i juli 2014 igenom en lagändring. Lagändringen innebär framför allt att hiss inte behöver installeras för

Märkning av färdigförpackade kakor och choklad i Ängelholms kommun – Uppfyller butikerna livsmedelslagstiftningens krav på livsmedelssäkerhet?

Kan allergiker lita på att chokladen är rätt märkt i butikerna i Ängelholm? För allergiker kan det bokstavligt talat vara livsavgörande att märkningen och informationen på produkter som choklad och kakor är korrekt i våra livsmedelsbutiker. Saknas tydlig information om allergener eller om informationen inte går att förstå p.g.a. att märkningen inte är på svenska kan en allergisk konsument i värstIn December 2014 the requirement increased on pre-packed food labelling when the regulation (EU) No 1169/2011 entered into force. Two important changes were that allergen information must be emphasised in the ingredients list and a minimum font size must be used for the obligatory information on food labels. It´s crucial that grocery stores follow the food legislation, so that consumers and especi

Applied hyperspectral LIDAR for monitoring fauna dispersal in aquatic environments

This thesis work has been focused on evaluation and further development of a hyperspectral LIDAR (Light Detection And Ranging) system made by Ljungholm et. al. [1] for monitoring of aquatic fauna, and in particular zooplankton. The project, which was a ”proof-of-concept”, showed the possibility to create a relatively compact and low-cost LIDAR with both spectral, temporal and range resolution. Exp

Investigation Of Scalloping Effects Of Radial Turbines With Computational Fluid Dynamics

Turbochargers should both have high efficiency and rapid engine response. By removing material from the rotating parts in the turbocharger, decreases the inertia. Most suited is the turbine in the turbocharger, which has high density because of nickel-based alloys. The material is removed between the radial blades in a shape that looks like a scallop and therefore called scalloping. Volvo Powertra

Free love and save the world: An anthropological analysis of how a free love culture is defined, maintained and communicated in the polyamorous community, Tamera, Portugal

This thesis investigates the social structures and discourse behind a culture of free love in a rural community in Portugal called Tamera. It describes how emotions and communication regarding personal romantic and sexual relationship are dealt with, as well as the incentives behind creating such a culture. Throughout the analysis I describe the political theory and vision behind the project Tamer

Acceptance of Simulation; Insights and Guidelines from a DES Project

Companies are daily facing challenges to become more efficient and to gain market shares. To solve these challenges discrete event simulation (DES) can be used as a strategic and tactical decision-making tool. Using simulation will result in; more cost effective analyses, less resources spent on implementation and an increased understanding of why things happen in the system. However, even if simu

Matsvinn - den osynliga tjuven: en studie av dagligvarubutikers arbete med hantering av matsvinn

Syftet med uppsatsen är att belysa hur företag inom dagligvaruhandeln arbetar med att hantera matsvinn. För att uppnå syftet med uppsatsen kommer vi att analysera två av de största dagligvarukedjorna i Sverige. Vårt bidrag inom retail management blir att öka kunskapen och förståelsen om rutiner och ledarskap som påverkar matsvinnshantering. För att uppnå syftet med uppsatsen har vi ställt följande

Reproducibility of bunches of electrons accelerated in laser driven wakefields

I Lund accelereras elektroner av superkorta och energirika laserpulser i ett plasma. Elektronerna accelereras från stillastående till väldigt nära ljusets hastighet på bara några få millimeter. Förhoppningen är att kunna ersätta dagens större och dyrare sätt att accelerera elektroner. Nyligen invigdes i Lund den stora synkrotronljusanläggningen MAX IV. Vid MAX IV accelereras elektroner i en långLaser wakefield acceleration (LWFA) utilises a high intensity laser pulse to excite a plasma density wave with associated large directed electric fields. These large electric fields can be used to accelerate electrons, making LWFA a good candidate for a compact electron beam source. In this dissertation, the impact of small fluctuations in laser pulse energy on the generated electron bunch charg

Paternal Depressive Symptoms during the Postpartum Period and Associated Psychosocial Factors in Singapore

Despite the fact that maternal postpartum depression has been extensively studied and addressed to be a significant mental health issue, the literature on paternal postpartum depression is limited, even more so for Asian countries. The present study aims to identify the psychosocial factors, as well as socio-demographic factors, that are associated with paternal postpartum depressive symptoms in S

Commissioning and Characterization of Two Undulators at the MAX IV 3 GeV Storage Ring

Insertion devices have several undesirable effects on the beam dynamics of a synchrotron storage ring, and these must be compensated for in order to ensure long term stable operation. This master’s thesis concerns the two first insertion devices at the MAX IV facility, two in-vacuum undulators for the BioMAX and NanoMAX beamlines. The report presents the work done to neutralize closed-orbit distor

Environmental Kuznets Curve: Evidence from the Nordic Countries 1961-2010

The relationship between economic growth and the environment, based on the theory of the Environmental Kuznets Curve (EKC), has been a topic of controversies, and a considerable number of studies have been devoted to investigate such relationship. In the current research the validity of EKC theory is tested on the Nordic countries, namely, Sweden, Denmark, Norway and Finland, over the period 1961