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Aims: Using a longitudinal approach, the aim of this study was to examine whether baseline engagement in arts and culture was associated with a decline from ‘Good’ to ‘Poor’ health at follow-up. Methods: Self-rated health (SRH) and engagement in six cultural activities among randomly selected Danish adults (⩾15 years) were assessed using data from the Danish Health and Wellbeing Survey in 2019. On
Preliminary results from the first archaeological excavations of Early Modern mercury-production sites at Idrija, Slovenia, confirm the use of ceramic vessels for mercury roasting following the techniques described in Agricola’s De re metallica, which was published in 1556.
Wood density is a crucial anatomical trait influencing forest carbon storage. However, dynamic global vegetation models (DGVMs) typically assume a fixed species-level wood density, neglecting environment-driven variability. In this proof-of-concept study, we explore the potential impact of dynamic wood density on tree- and forest-level carbon storage by integrating a simple temperature-response fu
One of the structuring logics behind the creation of news beats is the geographical one: that is, national, foreign and local news desks. Foreign and local beats, in particular, have a lot in common: the coverage of different geographical contexts increases the diversity and plurality of views; reporting from geographical peripheries is always the costliest in terms of production; the audience is
Background: Chronic limb-threatening ischaemia (CLTI) causes high rates of amputation and mortality. Objectives: To compare incidence, management and prognosis in hospitalised patients with CLTI with and without diabetes mellitus (DM) in 2001 and 2023. A secondary objective was to compare adherence to global vascular guidelines on risk factors between patients with and without DM in 2023. Design:
Objective: Childhood stunting is a significant health issue in Rwanda, particularly within the Northern Province. While demographic and socio-economic factors have been more extensively studied, the impact of environmental and climatic factors on stunting prevalence has received less attention. This study aimed to determine if these factors could be used to better predict localized variations in h
In urban growth modeling methods, researchers typically determine an appropriate scale based on various factors such as the extent of the study area, the scale of available data, and the level of detail required. With rapid urbanization, cities and towns have grown dramatically, leading to the emergence of numerous megalopolitan areas worldwide. In these areas, which include small and large cities
This master thesis aims to improve the physical design of smart ear tags for animals. The focus was to minimize the risk of tags falling off or causing harm, while considering environmental and animal welfare aspects. The project followed the methodology of Ulrich & Eppinger’s product development process, which included stages such as planning, concept development, and testing. Data collectio
Enhancers are central regulators of cell-type-specific gene expression, yet direct functional mapping of active enhancer-promoter interactions in single cells remains technically challenging. DNA adenine methyltransferase (Dam)-based chromatin recording offers a strategy to mark genomic regions proximal to proteins associated with active transcription sites in vivo, including enhancer regions, and
BackgroundAcute-phase proteins (APPs) reflect systemic inflammation and nutritional status, yet their perioperative trajectories and clinical utility as biomarkers of outcome in advanced ovarian cancer (aEOC) remain unclear. We aimed to characterise perioperative APP fluctuations and assess their associations with postoperative complications.MethodsThis observational study included patients underg
The criteria for Brief Resolved Unexplained Events (BRUE) are used to stratify the risk in infants presenting with apneic episodes. However, these criteria often classify a high proportion of infants as higher risk. This study aimed to investigate the etiology of apneic episodes, particularly those compatible with BRUE, and to assess whether age ≤60 days is associated with serious underlying condi
Dominant-inactivating mutations in the colony stimulating factor-1 receptor (CSF1R) cause CSF-1R related leukoencephalopathy (CRL), an adult-onset neurodegenerative disease that is modeled in the Csf1r+/– mouse. CRL is caused by microglial dysfunction. However, the primary microglial deficit, is unknown. To address this question, we employed single-nucleus RNA sequencing of brains from young Csf1r
This editorial introduces the special issue on the geography of innovation and sustainability transitions in the bioeconomy, situating the bioeconomy as a policy-driven transformation project with strong regional and multi-scalar implications. The special issue contains six papers that focus on different parts of the bioeconomy and employ a wide range of empirical approaches; jointly, they provide
UNLABELLED: In prostate cancer, androgen receptor (AR)-targeting agents are very effective in various disease stages. However, therapy resistance inevitably occurs, and little is known about how tumor cells adapt to bypass AR suppression. Here, we performed integrative multiomics analyses on tissues isolated before and after 3 months of AR-targeting enzalutamide monotherapy from patients with high
Natural products originating from microorganisms have been an important source of many successful lead molecules in the drug discovery and development process. The technological advances in analytical instrumentation and the development of various omics methodologies have provided new opportunities to accelerate the discoveries of new lead structures of microbial origin. Metabolomics is a rapidly
Sacituzumab govitecan (SG) is an antibody-drug conjugate (ADC) targeting TROP2, which has recently been approved for treatment-refractory metastatic urothelial cancer (UC). However, the variability of TROP2 expression across different bladder cancer (BC) subtypes, as well as after enfortumab vedotin (EV) exposure, remains unknown. Using gene expression data from four clinical cohorts with >1400 pa
Objective: To assess the risk of suicide after a diagnosis of urinary bladder cancer (UBC) compared with the standard population and to identify potential risk factors and time dependence associated with suicide in patients with UBC. Method: We used data from the Bladder Cancer Data Base Sweden 2.0 (BladderBaSe), including all individuals aged 18 years or older, diagnosed with UBC between 1997 and
