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Objectives: To analyse and present regression models that can describe the long-term change in cognitive function (MMSE and ADAS-cog) of patients treated with donepezil for three years (n=435). Methods: The Swedish Alzheimer Treatment Study (SATS) is an open, 3-year, multicentre study in a routine clinical setting. Patients with the diagnosis of Alzheimer’s Diseases received the cholinesterase inh
An unresolved issue in innovation studies is to what extent and how innovation is affected by changes in the economic environment of firms. This study elaborates on a theoretical framework that unites theories of innovation as creative response and the economics of complexity. In the empirical section, results from a new micro-based database on Swedish product innovations, 1970–2007, are introduce
Based on fieldwork among jade traders and carvers in Ruili, this chapter discusses the realization of economic and spiritual potentials of a type of jade called feicui翡翠 as determination of a partially indeterminate material. Some traders posit feicui as an empty container for economic value, while the material constitutes spiritual fullness especially for carvers. An opaque layer of surface skin
Denna bok handlar om hur kassaflöden före en viss period kan räknas fram utifrån resultat- och balansräkningar, med redovisningens logik i fokus. Bokens huvudsyfte är att skapa förståelse för sambandet mellan resultat- och balansräkningar å den enda sidan och kassaflöden å den andra. Därför beskrivs hur olika transaktioner behandlas i företagets redovisning och hur dessa påverkar företagets kassaf
Colorectal cancer (CRC) has a strong familial component which extends to discordant cancers (ie non-CRC tumors). This is best seen in cancer syndromes such as hereditary non-polyposis colorectal cancer (HNPCC) which predisposes to several tumor types. Population-based family studies have also found discordant associations for CRC but they have included cancers which manifest in HNPCC, and there is
For situations with radioactive material out of control where it may be physically difficult or prohibited to access areas close to the source, measurements from distance may be the only way to assess the radiation environment. Using collimated detectors will provide means to locate the direction of the radiation from the source. To investigate the possibilities of mapping gamma emitting radioacti
Recent emission legislation in the marine sector has emphasized the need to reduce nitrogen oxides (NOx) emissions as well as sulphur emissions. The fulfilment of emission legislation limits with conventional marine diesel oil (MDO) requires complex and expensive aftertreatment systems and in this framework lean burn pilot ignited dual fuel (diesel and natural gas) is revealed as one of the most s
Hunters and their families were one of the most exposed subpopulations in Sweden after the Chernobyl nuclear power plant accident in 1986. In this pilot study we used existing registries and whole-body measurements to develop algorithms to calculate lifetime effective doses and collective doses to some hunters in Sweden. Ten hunters and their family members were randomly selected from each of the
'Hot super-Earths' (or 'mini-Neptunes') between one and four times Earth's size with period shorter than 100 d orbit 30-50 per cent of Sun-like stars. Their orbital configuration - measured as the period ratio distribution of adjacent planets in multiplanet systems - is a strong constraint for formation models. Here, we use N-body simulations with synthetic forces from an underlying evolving gaseo
SH-SY5Y neuroblastoma cells are susceptible to differentiation using retinoic acid (RA) and brain-derived neurotrophic factor (BDNF), providing a model of neuronal differentiation. We compared SH-SY5Y cells proteome before and after RA/BDNF treatment using iTRAQ and phosphopeptide enrichment strategies. We identified 5587 proteins, 366 of them with differential abundance. Differentiated cells expr
Iridium(III)–pyridone complexes are commonly found to react in a cooperative and redox-neutral manner with dihydrogen and alcohols. In this work, the reactivity preferences of IrI–pyridone complexes were investigated under a variety of conditions. We have found that, in contrast to IrIII–pyridones, IrI–pyridone complexes display a strong preference to react non-cooperatively. With a new chelating
Background: Quality of life in persons with dementia is, in large part, dependent on the quality of care they receive. Investigating both subjective and objective aspects of quality of care may reveal areas for improvement regarding their care, which information may ultimately enable persons with dementia to remain living in their own homes while maintaining quality of life. The aim of this study
This study aims to reveal the effects of liquid entrainment, initial entrained fraction and tube diameter on liquid film dryout in vertical upward annular flow for flow boiling. Entrainment and deposition rates of droplets were included in mass conservation equations to estimate the local liquid film mass flux in annular flow, and the critical vapor quality at dryout conditions. Different entrainm
The Aw–Rascle–Zhang traffic model, a model of sedimentation, and other applications lead to nonlinear (Formula presented.) systems of conservation laws that are governed by a single scalar system velocity. Such systems are of the Temple class since rarefaction wave curves and Hugoniot curves coincide. Moreover, one characteristic field is genuinely nonlinear almost everywhere, and the other is lin
We have investigated strained GaAs-GaInP core-shell nanowires using transmission electron microscopy and nanofocused scanning X-ray diffraction. Nominally identical growth conditions for each sample were achieved by using nanoimprint lithography to create wafer-scale arrays of Au seed particles. However, we observe large individual differences, with neighboring nanowires showing either straight, b
Blood transfusions were dangerous and prohibited, until medicine developed modern techniques in the middle of the last century. Multi-trauma patients often present hard-to-identify multifactorial coagulopathies which should be recognized and treated before a transfusion is envisaged.
PURPOSE: To investigate assumed benefits of heparin coated cardiopulmonary bypass systems from standard non-coated CBP systems in unstable angina patients with preoperative heparinisation. STUDY DESIGN: Coagulation, complement, cytokine and Sonoclot parameters, were analyzed before total heparinisation prior to surgery, during cardiopulmonary bypass, after protamine to 48 hours after surgery. MATE
OBJECT: Subcutaneously intermittent administration of low molecular weight heparin (LMWH-Fragmin®) - (120IU/kgx2 BW) - in unstable angina was introduced clinically during the last year at our Hospital, after reports of the FRISC and FRIC studies as an alternative to continous infusion of standard heparin. In such patients with need for CABG, no data on haemostasis or anticoagulation during CBP had
OBJECT: Subcutaneously intermittent administration of low molecular weight heparin (LMWH-Fragmin®) - (120IU/kgx2 BW) -in unstable angina has been introduced clinically during the last year, after reports of the FRISC and FRIC studies as an alternative to continous infusion of standard heparin. Fragmin® could possible endanger postoperative haemostasis after CABG due to uncomplete reversal of anti-
A highly tunable linear triple quantum dot (TQD) device is realized in a single-crystalline pure-phase InAs nanowire using a local finger gate technique. The electrical measurements show that the charge stability diagram of the TQD can be represented by three kinds of current lines of different slopes and a simulation performed based on a capacitance matrix model confirms the experiment. We show t
