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Introduction: Therapeutic proteins are crucial in the treatment of a wide range of diseases. However, the proteins are sensitive to chemical degradation reactions, particularly deamidation and isomerization, which can compromise efficacy and safety. Formulation excipients, such as sugars and non-ionic surfactants, are commonly used to enhance stability, yet their effects on chemical degradation re
Drawing and sounding both rely on bodily movement as a basis for artistic expression. Movement provides the underlying spark that brings both visual and sonic practices to life. As part of a long-term research project titled ‘Sonic Kinesthetic Forest’, this paper reflects on a collaborative exchange between three researchers who use moving, drawing and sounding practices to deepen human relationsh
We developed a collagen microfiber-based 3D cancer tissue model that included monocytes. Using a sedimentation culture method, normal human dermal fibroblasts, endothelial cells, cancer cells, and THP-1 cells—that is, the human monocytes cell line—were cocultured under a high collagen density. THP-1 cells were differentiated into macrophages and showed M2-like polarization in the 3D tumor microenv
Invariant natural killer T 1 (iNKT1) cells are prototypic interferon γ-producing, innate-like T lymphocytes that play crucial roles in protection against pathogen infection and cancer. In the thymus, where these cells develop, iNKT cells contribute to the recruitment of antigen-presenting cells and promote T cell tolerance. Although the transcriptional programs guiding iNKT cell specification are
This scoping review aims to systematically explore the extent, nature, and gaps in the existing literature on self-care practices among adolescents and young adults aged 10–24 years living with type 1 diabetes mellitus (T1D) in Sub-Saharan Africa. The review will examine self-care knowledge, attitudes, practices, perceived barriers and facilitators, and interventions developed to support self-care
For the Inner Tracking System 3 (ITS3) upgrade, the ALICE experiment at CERN requires monolithic active pixel sensors of dimensions up to 97 mm×266 mm, occupying a large fraction of a 300 mm wafer. To manufacture such a wafer-scale device, larger than the single design reticle size, stitching is employed. The MOnolithic Stitched Sensor (MOSS) is a prototype silicon pixel sensor of 14 mm×259 mm siz
Alterations in cortical morphology have consistently been reported in obsessive-compulsive disorder (OCD). However, the microstructural properties of the cortex in OCD, including intracortical myelination, remain far less explored. The contrast between signal intensity in gray and subjacent white matter from T1-weighted magnetic resonance imaging (MRI), i.e. the gray/white matter contrast (GWC), i
IntroductionChanges in long-term survival after stroke at the population level are incompletely characterized, particularly using recent data and stratified by stroke type.Patients and MethodsThis nationwide, register-based cohort study used data from the Swedish Stroke Register (Riksstroke) and the Swedish Causes of Death Register. Adults (≥18 years) hospitalized with ischemic stroke or intracere
Objective: To develop machine-learning models that incorporate clinical information and radiomics features extracted from ultrasound images to distinguish uterine sarcomas from leiomyomas. Methods: This retrospective, multicenter, pilot case–control study included 200 patients (100 with a uterine sarcoma and 100 with a usual-type leiomyoma, i.e. including no benign leiomyoma variants) who underwen
Bird embryos develop inside eggs, which contain maternal substances that can shape offspring phenotype and fitness. Yolk fatty acids are a key energy source for the developing embryo, with omega-6 (ω-6) and omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) obtained exclusively from the diet. Therefore, food availability during the breeding season is expected to influence yolk fatty acid compositio
Intraspecific variation in phenotypic plasticity can affect the ability of populations, and thus species, to respond to environmental changes. However, the prevalence and drivers of such variation are not well known. Most proposed explanations for intraspecific variation in phenotypic plasticity involve mechanisms associated with a population's position within the species' geographic range or the
Sonic Kinesthetic Forest is an interdisciplinary research project that explores novel methodologies for studying trees and forests through embodied sound, movement and drawing practices. Our video article reflects on this interdisciplinary research through the lens of a performance piece in which embodied sound, movement and drawing practices were intricately interwoven with a forest landscape. Th
This chapter presents a speculative sonic process for creatively transforming environmental sounds in response to climate scenarios. Sound and listening are explored for attuning to and expressing changing relationships in landscapes due to the effects of drought. Field recordings undertaken in landscapes of Potsdam, Germany are processed in relation to sources, patterns and environmental states t
This paper presents a first prototype of ClimaSynth, a web-based interactive application that allows to creatively transform environmental sounds in response to climate change scenarios. ClimaSynth serves as an instrument for enhancing environmental perception through sonic interaction. The underlying algorithm uses real-time granular synthesis and web technologies to encode climatic effects in so
Multi-faceted objects and multi-sensory environments are constantly changing and shifting the way we use our senses, the way we perceive material and immaterial aspects of our environment and structure our experiences. How things co-exist, how they might be connected or be in a state of collision, defines the way we experience and interact with them. Through my work, I explore ways of sensing and
