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The crucial role of platelets in maintaining primary hemostais has been evident for a long time and there is now also mounting evidence for their involvement in inflammation. In combination with aspirin, inhibition of the platelet P2Y12 ADP receptor with clopidogrel has become a cornerstone in the antiplatelet in acute coronary syndromes. Recently, several studies have indicated that a considerabl
Based on detailed 2D and 3D numerical radiation-hydrodynamics (RHD)simulations of time-dependent compressible convection, we have studiedthe dynamics and thermal structure of the convective surface layers of aprototypical late-type M-dwarf (Teffapprox 2800 K, log g=5.0,solar chemical composition). The RHD models predict stellar granulationqualitatively similar to the familiar solar patt
Motivationen har stor betydelse för att rehabilitering ska ge ett gott resultat, det har studerats och förts till bevis i andra studier. Den första långtidsuppföljningen av motivationens betydelse ur ett hälsoekonomiskt perspektiv vid rehabilitering har genomförts i Kronobergs län.
Obesity is associated with increased triacylglycerol (TAG) storage in adipose tissue and insulin resistance. The mobilization of stored TAG is mediated by hormone-sensitive lipase (HSL) and the recently discovered adipose triglyceride lipase (ATGL). The aim of the present study was to examine whether ATGL and HSL mRNA and protein expression are altered in insulin-resistant conditions. In addition,
Production of cyclodextrins (CDs) by immobilized cells of the alkaliphilic Bacillus agaradhaerens LS-3C with integrated product recovery was studied. The microorganism was entrapped in polyvinyl alcohol-cryogel beads and used as a convenient source of immobilized cyclodextrin glycosyltransferase (CGTase). On activation by incubation in the cultivation medium containing 1% (w/v) starch, the entrapp
The role of the DEK protein, involved in the leukemia-associated fusion protein DEK-CAN, is not yet known. In this study, we show a higher expression of DEK mRNA in immature cells than in mature cells. Furthermore, a correlation between DEK expression and cell proliferation was demonstrated, suggesting that DEK plays a role in the proliferation of hematopoietic cells and raising the question of wh
Fukt i alla former, vatten, ånga, is eller snö finns alltid i varierande mängder i och omkring byggnader. För att byggnaden skall fungera tillfredsställande krävs att dessa fuktmängder kan hållas inom vissa gränser. Detta kan åstadkommas genom att utrusta, konstruera och bruka byggnaden på ett riktigt sätt. Exempel på olägenheter som kan uppstå vid ''felaktigt'' fuktinnehåll är: försämrad värmeiso
Ever since environmental issues appeared on the agenda of modern industrial society, through the work of whistle blowers such as Rachel Carson, Georg Borgström, Björn Gillberg and Hans Palmstierna, the Swedish state has exerted itself to project a green image. In practice this image has merely functioned as a defence for the legitimacy of industrial development. The state has created environmental
Gentrification is a current and often debated concept that concerns social changes in our cities. The concept relates to a development whereby areas earlier inhabited by less wealthy social groups are taken over by middle and upper middle-class residents. In the discussions of these changes, two perspectives have dominated. Representatives for the consumer perspective argue that gentrification occ
Background Acetabular cementation during total hip arthroplasty is considered difficult mainly due to the appearance and anatomy of the acetabulum. Improved cementation technique has been shown to improve the longevity of acetabular components. Method We designed a ceramic model to investigate the effect of varying the initial cement pressurization and cup introduction times on the depth of cemen
Recent immunohistochemical findings suggested that a constitutive nitric oxide synthase (cNOS) resides in endocrine pancreas. Here we provide direct biochemical evidence for the presence of cNOS activity in isolated islets. The regulating influence of this nitric oxide synthase (NOS) activity for islet hormone release was also investigated. We observed that cNOS activity could be quantitated in is
The development of the red colour in copper ruby alkali silicate glasses has been studied by means of ultraviolet/visible spectroscopy, TEM and EXAFS. The results show that in both red and slightly overstruck, brownish glasses the colour is due to clusters of metallic copper. Before striking non-coloured glasses contain mainly cuprous ions, Cu+. Tin acts as a reducing agent but also has an acceler
alpha-Trinositol (D-myo-inositol-1,2,6-trisphosphate), an isomer of the intracellular messenger IP3, has been studied for its anti-inflammatory and other effects in animal experiments and in human. The mechanisms of action remain unknown. Several human pathologies are associated with uncontrolled production of fibroblast growth factors (FGFs). FGF-2 induces vascular smooth muscle cell proliferatio
An all-solid-state fast-tuning lidar transmitter for range- and temporally resolved atmospheric gas concentration measurements has been developed and thoroughly tested. The instrument is based on a commercial optical parametric oscillator (OPO) laser system, which has been redesigned with piezoelectric transducers mounted on the wavelength-tuning mirror and on the crystal angle tuning element in t
We studied the foraging technique of Ospreys Pandion haliaetus during different wind speed conditions at Lake Hammarsjon, Sweden in autumn 2003. Different fishing techniques were used with a shift in relation to wind speed: (1) without hovering, (2) hovering with pure flapping flight, (3) hovering with flapping flight and gliding into the wind, and (4) hovering with pure gliding. The results suppo
