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Aims Alternative splicing of Titin (TTN) I-band exons produce protein isoforms with variable size and elasticity, but the mechanisms whereby TTN splice factors regulate exon usage and thereby determining cardiomyocyte passive stiffness and diastolic function, is not well understood. Non-coding RNA transcripts from the antisense strand of protein-coding genes have been shown to regulate alternative

Forward-only algorithms offer a promising memory-efficient alternative to Backpropagation (BP) for on-device training. However, state-of-the-art forward-only algorithms, e.g., Forward-Forward (FF), still require a substantial amount of memory during the training process, often exceeding the limits of mobile edge and Internet of Things (IoT) devices. At the same time, existing memory-optimization t

Despite the crucial role of various insulin analogs in achieving satisfactory glycemic control, a comprehensive understanding of their in-solution dynamic mechanisms still holds the potential to further optimize rapid insulin analogs, thus significantly improving the well-being of individuals with Type 1 Diabetes. Here, we employed hydrogen-deuterium exchange mass spectrometry to decipher the mole

Marknadsföring är så mycket mer än strategier, marknadsundersökningar och reklamkampanjer. Den uppstår i det dagliga samspelet mellan människor. I Marknadsföring, människor och interaktion får vi ett alternativt perspektiv på marknadsföring, bortom den traditionella marketing management-logiken. Genom att utgå från symbolisk interaktionism synliggör författarna hur marknader, konsumenter, produkte

We present the artillery of a well-preserved late medieval Danish-Norwegian carvel warship, Gribshunden. Probably built in the Netherlands in 1484, the ship served King Hans until sinking in June 1495. Of its original 50 or more guns, elements of 11 have been recovered and digitally recreated, and more remain on the wreck. Investigation of this site provides insights into the development of shipboWe present the artillery of a well-preserved late medieval Danish-Norwegian carvel warship, Gribshunden. Probably built in the Netherlands in 1484, the ship served King Hans until sinking in June 1495. Of its original 50 or more guns, elements of 11 have been recovered and digitally recreated, and more remain on the wreck. Investigation of this site provides insights into the development of shipbo

Pulmonary arterial hypertension (PAH) is a heterogenic diagnosis including idiopathic and hereditary PAH (IPAH/HPAH) and groups associated to connective tissue disease (APAH-CTD) and congenital heart disease (APAH-CHD). Pre- and post-diagnosis societal costs in PAH subgroups are not well known. By linking Swedish national databases, societal costs in a national PAH cohort 5 years before and 5 year

Achieving sustainable development goals requires strategically balancing the trade-off between water resource utilization and carbon emissions. It is of particular importance to systematically study the relationships between water conservation and emission reduction (water-carbon relationship) in a water intake system, and to optimize the water intake structure accordingly. This study proposes a m

Wetlands play a critical role in the global water cycle and ecological health. However, understanding and accurately parameterizing water and heat exchanges in these areas is challenging due to the heterogeneous nature of wetland surfaces. This study extends the maximum entropy production (MEP) model to simulate wetland evapotranspiration (ET) by integrating NDVI dynamics, water evaporation, and p

Methane (CH4) oxidation in well-drained soils is a key process contributing to the global CH4 sink. Yet, temporal and depth-specific CH4 oxidation is rarely described despite being critical for the surface net CH4 uptake. Here, we linked year-round field observations of CH4 fluxes in well-drained cultivated soils with subsurface CH4 concentrations, laboratory incubations, and process-based modelin

Public trust plays a fundamental role in shaping national energy policies in democratic countries, as exemplified by nuclear phase-out in Germany following the Fukushima accident. While trust dynamics have been explored in different contexts of the energy transition, few studies have attempted to quantify the influence of public trust in shaping social acceptance and adoption potential. Moreover,

Altermagnetism exhibits unique physical properties such as spin-momentum locking, anomalous Hall effect, nontrivial topological phase, and giant magnetoresistance. Among all the predicted candidates, several room-temperature altermagnets are suggested to host significant potential applications. RuO2 has been proposed as the most promising candidate. However, recently, there is intense debate about

Wood–water interactions are central to wood science, technology, and engineering. In the early twentieth century, the term “fiber saturation point” was coined to refer to the point of transition from the domain where wood properties change with moisture content to the domain where wood properties are constant. This conceptual model assumed that the wood cell walls are water saturated at this trans

The growing demand for batteries, driven by the rapid growth of electric vehicles and renewable energy technologies, has led to increased focus on their lifecycle management. While batteries may reach the end of their primary life, they often have the potential for a second life, offering valuable services before their eventual recycling. This paper presents a comprehensive business model framewor

We investigate how local distinguishability can restrict global properties of states shared between two parties. We begin exploring how nonlocality becomes limited by local state discrimination and observe a nontrivial tradeoff between Clauser-Horne-Shimony-Holt (CHSH) violation and success probability of local discrimination. We extend our findings to bounding the maximally entangled state fideli

Aims This post-hoc analysis of the ATHENA trial assessed whether dronedarone (400 mg twice daily) improved cardiovascular outcomes compared with placebo in patients with early atrial fibrillation/atrial flutter (AF) and cardiovascular comorbidities, based on EAST-AFNET 4 inclusion criteria and outcomesMethods The co-primary outcomes were (i) a composite of cardiovascular death, stroke, or hospital

The atmospheric melting layer (AML), where snow transitions into rain, influences satellite signals, precipitation remote sensing, and a range of hydro-meteorological applications. AML has been extensively studied using radar technology, but methods for continuous and consistent monitoring remain limited. This paper presents the first comprehensive review of AML research, with a focus on the Micro