The SYT-SSX fusion gene has been implicated in the malignant tumor cell growth of synovial sarcoma, but the underlying molecular mechanisms are still poorly understood. Here we demonstrate that SYT-SSX is critical for the protein level of cyclin D1 in synovial sarcoma cells. Antisense oligonucleotides to SYT-SSX mRNA rapidly and drastically decreased cyclin D1 and subsequently inhibited cell growt

Breakup reactions were used to study the ground-state configuration of the neutron-rich isotope 23O. The 22O fragments produced in one-nucleon removal from 23O at 938 MeV/nucleon in a carbon target were detected in coincidence with de-exciting γ rays, allowing to discern between 22O ground-state and excited-states contributions. From the comparison of exclusive experimental momentum distributions

In the history of English language research on computerised corpora, the year 1977 marks an important event with the birth of ICAME - the International Computer Archive of Modern and Medieval English - which set off international co-operation on a large scale. The use of computer corpora, from being a fringe activity, has become a mainstream methodology. Yet there was corpus life also before ICAME

We establish a higher-dimensional version of multifractal analysis for several classes of hyperbolic dynamical systems. This means that we consider multifractal decompositions which are associated to multi-dimensional parameters. In particular, we obtain a conditional variational principle, which shows that the topological entropy of the level sets of pointwise dimensions, local entropies, and Lya

Splitting the Nash single linear reservoir into two serially connected reservoirs of unequal storage coefficients (one hybrid unit) for a physically realistic response, a hybrid model is introduced for derivation of a synthetic unit hydrograph. Empirical relations are given for estimation of the two storage coefficients from known peak flow (qp) and time to peak (tp). The hybrid model with two ser

Scientific knowledge develops in an increasingly fragmentary way. A multitude of scientific disciplines branch out. Curiosity for this development leads into quests for a unifying understanding. To a certain extent, foundational studies provide such unification. There is a tendency, however, also of a fragmentary growth of foundational studies, like in a multitude of disciplinary foundations. We s

Temporal trend studies of PCBs and DDTs in two annually laminated sediment cores from the offshore NW Baltic proper and the Stockholm archipelago demonstrate that studies of laminated sediments are useful tools for detecting time trends of HOCs. The concentration trends of PCBs and DDTs, on a dry weight basis, from the two cores show quite large similarities to trends reported in pelagic biota fro

In the first century CE, synagogues existed not only in the land of Israel but in all parts of the Roman Empire where Jews lived. Although incorporating a number of activities, the most characteristic features of this institution were the public reading and teaching of torah, making the synagogue an unparalleled institution in the ancient world. But how, when, where, and why did this unique instit

Popular Abstract in Swedish Avregleringen av elmarknaden uppmuntrar kraftbolag och oberoende kraftproducenter till att driva sina kraftverksanläggningar på ett marknadsorienterat sätt. För att behålla de ekonomiska marginalerna på plussidan så har de mest populära åtgärderna varit att förbättra elverkningsgraden genom ändringar i hårdvaran samt höja totalverkningsgraden genom till exempel samproduThe deregulation of the electricity market drives utilities and independent power producers to operate heat and power plants as profit centers. In order to keep the economic margins on the credit side, the preferred measures have been to improve the electrical efficiency through changes in the hardware and boost the overall efficiency through e.g. combined heat and power (CHP) generation. The bett

Popular Abstract in Swedish Denna avhandling har två huvudsakliga syften. Det första syftet är att bidra med en fördjupad kunskap kring demokratins begränsningar och möjligheter i en tid av tilltagande globalisering och gränsöverskridande politisk verksamhet. Även om detta syfte i hög grad aktualiserar frågan om den nationella demokratins fortsatta verkansmöjligheter, är fokus ställd på möjligheteThis book has two overarching objectives. Firstly, in an age of increasing globalization and cross-border political activities it seeks to contribute to the debate on the limits and possibilities of democracy in the present and in the future. Even though this objective brings to the fore the issue of democracy in a national context, the main ambition is to examine democratic values and institution

Popular Abstract in Swedish Strategiska allianser utgör en tillväxtstrategi som har blivit ett allt vanligare inslag i näringslivet. Även forskningsbidragen kring strategiska allianser har vuxit i omfattning. Dessa forskningsbidrag har i stor utsträckning utgått från ett ekonomiskt/rationellt perspektiv samt fokuserat på de inledande faserna i samarbetet, med inriktning på motiv och val av samarbeThe purpose of this thesis is to develop an increased understanding of strategic alliance processes. A specific aim has been to explore the trust processes involved, and to better understand the dynamics of the strategic alliance processes. The study includes socio-cultural elements and captures both the manager´s and the employee´s perspectives in everyday life. The theoretical discussions were b

OBJECTIVE: To evaluate the long-term outcome of patients treated in the surgical intensive care unit (SICU) for abdominal sepsis. DESIGN: Retrospective study. SETTING: University hospital, Sweden. SUBJECTS: 210 consecutive patients treated for abdominal sepsis in the SICU at Lund University Hospital during the period January 1983 to December 1995. MAIN OUTCOME MEASURES: Background information, mor

Recension av Simon Schama, Skog – Landskap och minne. En civilisationshistoria.

In response to increasing frequencies of penicillin-non-susceptible pneumococci (PNSP), for which the MIC of penicillin was greater than or equal to0.12 mg/L, in Sk (a) over circle ne County, southern Sweden, national recommendations were initiated in 1995 to limit the spread of pneumococci with high MICs (greater than or equal to0.5 mg/L) of penicillin (PRP), especially among children of preschoo

Twenty M protein-positive and eight M protein-negative strains of group A streptococci were investigated with respect to surface hydrophobicity and amount of lipoteichoic acid (LTA). Surface hydrophobicity as determined in polymer two-phase systems varied substantially between individual strains and there was no correlation to the presence of antiphagocytic M protein. The amount of LTA on the surf